New drug combo shows safety promise for tough breast cancer

NCT ID NCT05631795

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 28 times

Summary

This study tested the safety of two drugs, alpelisib and fulvestrant, in 40 men and postmenopausal women with a specific type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that had worsened after hormone therapy. The goal was to see how many people had side effects during treatment. Results help doctors understand the risks of this combination for controlling the disease.

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Contacts and locations

Locations

  • Novartis Investigative Site

    Guwahati, Assam, 781016, India

  • Novartis Investigative Site

    Surat, Gujarat, 395009, India

  • Novartis Investigative Site

    Thalassery, Kerala, 670103, India

  • Novartis Investigative Site

    Trivandrum, Kerala, 695 011, India

  • Novartis Investigative Site

    Bhopal, Madhya Pradesh, 462001, India

  • Novartis Investigative Site

    Mumbai, Maharashtra, 400 012, India

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440001, India

  • Novartis Investigative Site

    Pune, Maharashtra, 411040, India

  • Novartis Investigative Site

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Novartis Investigative Site

    Hyderabad, Telangana, 500004, India

  • Novartis Investigative Site

    Ahmedabad, 380016, India

  • Novartis Investigative Site

    Kolkata, 700026, India

Conditions

Explore the condition pages connected to this study.