Can a weekly infusion protect lungs in Alpha-1 emphysema?
NCT ID NCT01983241
First seen Mar 16, 2026 · Last updated May 10, 2026 · Updated 8 times
Summary
This study tests whether a weekly intravenous dose of Alpha-1 MP (a protein that protects the lungs) can slow the progression of emphysema in people with Alpha-1 antitrypsin deficiency. About 345 participants receive either 60 mg/kg, 120 mg/kg, or a placebo for 3 years. The main goal is to measure changes in lung density via CT scans.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Grifols Investigative Site
Phoenix, Arizona, 85013, United States
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Grifols Investigative Site
Gainesville, Florida, 32610, United States
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Grifols Investigative Site
Leesburg, Florida, 34748, United States
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Grifols Investigative Site
Miami, Florida, 33136, United States
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Grifols Investigative Site
St Louis, Missouri, 63110, United States
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Grifols Investigative Site
Wilmington, North Carolina, 28401, United States
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Grifols Investigative Site
Portland, Oregon, 97239, United States
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Grifols Investigative Site
Hershey, Pennsylvania, 17033, United States
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Grifols Investigative Site
Charleston, South Carolina, 29425, United States
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Grifols Investigative Site
Tyler, Texas, 75708, United States
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Grifols Investigative Site
Vicente López, Buenos Aires, B1602DOH, Argentina
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Grifols Investigative Site
Córdoba, Córdoba Province, 5000, Argentina
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Grifols Investigative Site
Sydney, New South Wales, 2010, Australia
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Grifols Investigative Site
Chermside, Queensland, 4032, Australia
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Grifols Investigative Site
Adelaide, South Australia, 5000, Australia
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Grifols Investigative Site
Fitzroy, Victoria, 3065, Australia
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Grifols Investigative Site
Nedlands, Western Australia, 6009, Australia
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Grifols Investigative Site
Santo André, São Paulo, 09060-650, Brazil
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Grifols Investigative Site
São Paulo, São Paulo, 04023-061, Brazil
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Grifols Investigative Site
São Paulo, São Paulo, 05403-000, Brazil
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Grifols Investigative Site
St. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Grifols Investigative Site
Halifax, Nova Scotia, B3H3A8, Canada
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Grifols Investigative Site
Toronto, Ontario, M5T3A11, Canada
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Grifols Investigative Site
Arhus C, 8000, Denmark
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Grifols Investigative Site
Hellerup, 2900, Denmark
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Grifols Investigative Site
Tallinn, 13419, Estonia
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Grifols Investigative Site
Tartu, 51014, Estonia
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Grifols Investigative Site
Turku, 20520, Finland
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Grifols Investigative Site
Pessac, Gironde, 33604, France
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Grifols Investigative Site
Bron, Rhone, 69500, France
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Grifols Investigative Site
Heidelberg, Baden-Wurttemberg, 69126, Germany
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Grifols Investigative Site
Marburg, Hesse, 35043, Germany
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Grifols Investigative Site
Essen, North Rhine-Westphalia, 45239, Germany
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Grifols Investigative Site
Homburg Saar, 66421, Germany
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Grifols Investigative Site
Chisinau, 2025, Moldova
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Grifols Investigative Site
Auckland, 1051, New Zealand
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Grifols Investigative Site
Christchurch, 8013, New Zealand
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Grifols Investigative Site
Hamilton, 3240, New Zealand
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Grifols Investigative Site
Krakow, 31-066, Poland
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Grifols Investigative Site
Warsaw, 01-138, Poland
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Grifols Investigative Site
Oradea, 410176, Romania
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Grifols Investigative Site
Timișoara, 300312, Romania
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Grifols Investigative Site
Barnaul, 656038, Russia
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Grifols Investigative Site
Moscow, 105077, Russia
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Grifols Investigative Site
Yaroslavl, 150003, Russia
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Grifols Investigative Site
Oviedo, Principality of Asturias, 33011, Spain
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Grifols Investigative Site
Barakaldo, Vizcaya, 48903, Spain
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Grifols Investigative Site
Gothenburg, 41345, Sweden
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Grifols Investigative Site
Linköping, 587 58, Sweden
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Grifols Investigative Site
Malmö, 20502, Sweden
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Grifols Investigative Site
Stockholm, 11361, Sweden
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Grifols Investigative Site
Uppsala, 752 37, Sweden
Conditions
Explore the condition pages connected to this study.