New drug combo targets Hard-to-Treat endometrial cancer
NCT ID NCT05154487
First seen Mar 03, 2026 · Last updated Apr 28, 2026 · Updated 5 times
Summary
This study tests two drugs, alpelisib and fulvestrant, in 51 people with advanced or returning endometrioid endometrial cancer that has a specific gene change (PIK3CA mutation) and is estrogen-receptor positive. The goal is to see if the combination can shrink tumors. Treatment continues until side effects become too severe, the cancer worsens, or the patient chooses to stop.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AdventHealth Gynecologic Oncology
Orlando, Florida, 32804, United States
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Ascension St. Vincent
Indianapolis, Indiana, 46260, United States
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City of Hope
Duarte, California, 91010, United States
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Johns Hopkins Medicine
Baltimore, Maryland, 21287, United States
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Kettering Health Cancer Center
Kettering, Ohio, 45429, United States
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Legacy Good Samaritan Medical Center
Portland, Oregon, 97210, United States
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Legacy Meridian Park Medical Center
Tualatin, Oregon, 97062, United States
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Legacy Salmon Creek Medical Center
Vancouver, Washington, 98686, United States
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Moffit Cancer Center at International Plaza
Tampa, Florida, 33607, United States
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Moffit Cancer Center at Wesley Chapel
Wesley Chapel, Florida, 33544, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
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Northwell Health Cancer Institute
Lake Success, New York, 11042, United States
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Norton Cancer Institute
Louisville, Kentucky, 40241, United States
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Oklahoma Cancer Specialists and Research Institute, LLC
Tulsa, Oklahoma, 74146, United States
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QCC- Northwell Health Physicians Partners Medical
Rego Park, New York, 11374, United States
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Tampa General Hospital
Tampa, Florida, 33606, United States
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University of Wisconsin Clinical Science Center
Madison, Wisconsin, 53792, United States
Conditions
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