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Could aloe vera calm an infected tooth?

NCT ID NCT07826091

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers at Ain Shams University are testing whether aloe vera gel, placed inside a tooth after root canal cleaning, reduces inflammation and pain better than the standard calcium hydroxide dressing. The trial enrolls 33 adults with dead or dying teeth and infection around the root tip. Participants receive one of the two medications for 14 days, and researchers measure an inflammation marker in fluid around the root and track pain levels before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aloe vera gel placed inside the tooth as an antibacterial and anti-inflammatory dressing
What this could lead to
If aloe vera works, it could offer a plant-based, low-cost option for calming inflammation and pain between dental visits.
What could go wrong
This is a small single-center study of 33 people with one type of tooth problem. Aloe vera may not outperform standard calcium hydroxide, and results may not apply to other dental infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

Aug 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Both genders. 2. Older than the age of 18 years. 3. Medically free patients. 4. Participants should be willing to commit for the entire period of the trial and agreed to sign the written informed consent after complete explanation of the study protocol. 5. Participants with single rooted necrotic teeth with apical periodontitis, symptomatic (Visual analogue scale "VAS" and pain on percussion) or Asymptomatic (Radiographic evidence of apical periodontitis). Exclusion Criteria: 1. Presence of Allergic reaction. 2. Participants taking antibiotics or NSAIDs. 3. Severely curved root. 4. Endodontically treated teeth. 5. Teeth with open apices.

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Necrotic teeth with apical periodontitis

Contacts and locations

Locations

  • Faculty of dentistry, Ain shams university

    Cairo, Abbasia, 11566, Egypt