Experimental brain injection aims to slow dangerous blood vessel disease

NCT ID NCT06393712

Recruiting now Disease control Sponsor: Alnylam Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a medication called ALN-APP, given as an injection into the spinal fluid, can slow down the progression of cerebral amyloid angiopathy (CAA). CAA is a disease where a sticky protein builds up in the brain's blood vessels, making them fragile and prone to bleeding. The trial will enroll 200 adults with CAA to compare the drug against a placebo, tracking new brain bleeds and safety over two years.

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Contacts and locations

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Study contacts

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Locations

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Los Angeles, California, 90095, United States
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Orange, California, 92868, United States
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Palo Alto, California, 94304, United States
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Sacramento, California, 95816, United States
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San Francisco, California, 94114, United States
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Aurora, Colorado, 80045, United States
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New Haven, Connecticut, 06510, United States
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Gainesville, Florida, 32608, United States
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Jacksonville, Florida, 32224, United States
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Maitland, Florida, 32751, United States
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Naples, Florida, 34105, United States
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Chicago, Illinois, 60612, United States
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Lexington, Kentucky, 40504, United States
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New Orleans, Louisiana, 70121, United States
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Boston, Massachusetts, 02114, United States
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Plymouth, Massachusetts, 02360, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Hackensack, New Jersey, 07601, United States
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New York, New York, 10016, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Durham, North Carolina, 27705, United States
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Canton, Ohio, 44718, United States
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Cleveland, Ohio, 44195, United States
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Abington, Pennsylvania, 19001, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Dallas, Texas, 75243, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77030, United States
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San Antonio, Texas, 78229, United States
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Seattle, Washington, 98104, United States
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Adelaide, 5000, Australia
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Brisbane, 4029, Australia
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Heidelberg, 3084, Australia
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Nedlands, 6009, Australia
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Parkville, 3050, Australia
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Calgary, T2N 4Z6, Canada
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Hamilton, L8L 2X2, Canada
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Kelowna, V1Y 1Z9, Canada
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Moncton, E1C 2Z3, Canada
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Montreal, H3A 2B4, Canada
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Montreal, H3G 1H9, Canada
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Ottawa, K1Z 1G3, Canada
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Toronto, M3B 2S7, Canada
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Victoria, V8R 1J8, Canada
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Amsterdam, 1081 GN, Netherlands
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Leiden, 2333ZA, Netherlands
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Nijmegen, 6525 GA, Netherlands
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Bern, 3010, Switzerland
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Geneva, 1205, Switzerland
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TERMINATED

Sankt Gallen, 9007, Switzerland
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Glasgow, G51 4TF, United Kingdom
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London, SE5 8AF, United Kingdom
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London, WC1N 3BG, United Kingdom

Conditions

Explore the condition pages connected to this study.

CEREBRAL AMYLOID ANGIOPATHY