Off-the-Shelf CAR t cells show promise for Hard-to-Treat myeloma
NCT ID NCT04093596
First seen May 14, 2026 · Last updated May 16, 2026 · Updated 1 time
Summary
This early-phase study tested a new type of CAR T cell therapy, called ALLO-715, in 73 adults with multiple myeloma that had returned or stopped responding to at least three prior treatments. Unlike standard CAR T cells made from a patient's own cells, ALLO-715 is made from a healthy donor's cells, so it's ready to use off the shelf. The study also looked at adding a drug called nirogacestat to see if it could help the CAR T cells work better. The main goals were to check safety and find the right dose.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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City of Hope
Duarte, California, 91010, United States
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Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Sarah Cannon/Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
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St. David's South Austin Medical Center
Austin, Texas, 78704, United States
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Stanford Cancer Institute
Palo Alto, California, 94305, United States
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Texas Transplant Institute
San Antonio, Texas, 78229, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37203, United States
Conditions
Explore the condition pages connected to this study.