Off-the-Shelf CAR t cells take on Hard-to-Treat myeloma
NCT ID NCT04093596
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested a new type of CAR T cell therapy, called ALLO-715, made from donor cells (not the patient's own). It was given to 73 adults with multiple myeloma that had come back or stopped responding to at least three prior treatments. The goal was to check safety and see if adding another drug, nirogacestat, could help the CAR T cells work better. Because this is a disease-control approach and not a cure, patients may still need ongoing management.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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City of Hope
Duarte, California, 91010, United States
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Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Sarah Cannon/Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
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St. David's South Austin Medical Center
Austin, Texas, 78704, United States
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Stanford Cancer Institute
Palo Alto, California, 94305, United States
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Texas Transplant Institute
San Antonio, Texas, 78229, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37203, United States