New heart valve procedure shows promise for High-Risk patients

NCT ID NCT03613246

First seen Nov 17, 2025 · Last updated May 05, 2026 · Updated 14 times

Summary

This study looks at how well the ALLEGRA TAVI system works in real-world patients with severe, hardened aortic heart valves who are too high-risk for open-heart surgery. Researchers tracked 346 patients to see if the procedure helps them live longer and feel better. The goal is to control the disease and improve quality of life without the need for major surgery.

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Contacts and locations

Locations

  • Clinica Mediterranea Neapel

    Naples, Italy

  • Heartcentre Catharina Hospital Eindhoven

    Eindhoven, 5623 EJ, Netherlands

  • Herz- und Gefäßzentrum Bad Bevensen

    Bad Bevensen, 29549, Germany

  • Hospital Alvaro Cunqueiro

    Vigo, 36213, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Kath. Marienkrankenhaus

    Hamburg, 22087, Germany

  • MH Hannover

    Hanover, 30625, Germany

  • Morriston Hospital

    Swansea, United Kingdom

  • Ospedale San Raffaele

    Milan, 20132, Italy

  • Oulu University Hospital

    Oulu, 90220, Finland

  • SLK-Kliniken Heilbronn

    Heilbronn, 74078, Germany

  • Schuechtermann-klinik

    Bad Rothenfelde, Germany

Conditions

Explore the condition pages connected to this study.