Leukemia drug dosing trial aims to boost cure rates and cut side effects

NCT ID NCT02716233

First seen Nov 01, 2025 · Last updated Apr 26, 2026 · Updated 24 times

Summary

This study looks at how to best give the drug pegaspargase to children and teens with acute lymphoblastic leukemia (ALL). About 2,000 participants will receive either one or two doses during early treatment to see which approach works better and causes fewer severe side effects. The goal is to improve the already high cure rates while making treatment safer.

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Contacts and locations

Locations

  • CHRU

    Besançon, 25030, France

  • CHU

    Amiens, 80054, France

  • CHU

    Angers, 49033, France

  • CHU

    Bordeaux, 33076, France

  • CHU

    Brest, 29609, France

  • CHU

    Caen, 14033, France

  • CHU

    Clermont-Ferrand, 63003, France

  • CHU

    Dijon, 21079, France

  • CHU

    Grenoble, 38043, France

  • CHU

    Lille, 59037, France

  • CHU

    Limoges, 87042, France

  • CHU

    Marseille, 13385, France

  • CHU

    Montpellier, 34295, France

  • CHU

    Nancy, 54511, France

  • CHU

    Nantes, 44093, France

  • CHU

    Nice, 06200, France

  • CHU

    Poitiers, 86000, France

  • CHU

    Reims, 51100, France

  • CHU

    Rennes, 35203, France

  • CHU

    Rouen, 76031, France

  • CHU

    Saint-Etienne, 42270, France

  • CHU

    Strasbourg, 67098, France

  • CHU

    Toulouse, 31059, France

  • CHU

    Tours, 37044, France

  • CHU Armand Trousseau

    Paris, 75012, France

  • CHU Robert Debré

    Paris, 75019, France

  • CHU Saint Louis

    Paris, 75010, France

  • Chu-Ihope

    Lyon, 69373, France

Conditions

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