New hepatitis b drug shows promise in Mid-Stage trial

NCT ID NCT06963710

Recruiting now Disease control Sponsor: Aligos Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study tests an experimental drug called ALG-000184 against a standard hepatitis B medication (tenofovir) in 200 adults with chronic hepatitis B. Participants take one pill daily for 48 weeks. The main goal is to see if the new drug can lower hepatitis B virus levels in the blood more effectively than the current treatment. Researchers will also monitor for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALG-000184 (an experimental antiviral drug)
What this could lead to: If successful, ALG-000184 could offer a new oral treatment option for chronic hepatitis B, potentially suppressing the virus more effectively than current therapies.
What could go wrong: This is an early Phase 2 study with only 200 participants, so results may not apply to everyone. The drug may not prove superior to existing treatments, and side effects are still being evaluated.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS B INFECTION

Contacts and locations

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Study contacts

Contact

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Locations

Aligos Investigational Site
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Chandler, Arizona, 85224, United States

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Coronado, California, 92118, United States

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Garden Grove, California, 92840, United States

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Los Angeles, California, 90033, United States

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Palo Alto, California, 94304, United States

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Pasadena, California, 91105, United States

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Rialto, California, 92377, United States

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Aligos Investigational Site
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San Francisco, California, 94117, United States

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San Jose, California, 95116, United States

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Aligos Investigational Site
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Miami, Florida, 33136, United States

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Miami, Florida, 33173, United States

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Marrero, Louisiana, 70072, United States

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Baltimore, Maryland, 21287, United States

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Chevy Chase, Maryland, 20815, United States

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Aligos Investigational Site
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Boston, Massachusetts, 02114, United States

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Aligos Investigational Site
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Manhasset, New York, 10075, United States

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New York, New York, 10016, United States

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Durham, North Carolina, 27710, United States

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Sliven, Bulgaria

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Stara Zagora, Bulgaria

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Edmonton, Canada

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Ottawa, Canada

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Toronto, Canada

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Changchun, China

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Chengdu, China

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Chongqing, China

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Nanjing, China

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Clichy, France

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Limoges, France

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Nice, France

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Rennes, France

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Rouen, France

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Toulouse, France

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Milan, Italy

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Chisinau, Moldova

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Auckland, New Zealand

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Ansan, South Korea

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Busan, South Korea

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Ulsan, South Korea

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Yangsan, South Korea

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Barcelona, Spain

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NOT_YET_RECRUITING

Pontevedra, Spain

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Chiayi City, Taiwan

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Kaohsiung City, Taiwan

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Taichung, Taiwan

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Tainan, Taiwan

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Taipei, Taiwan

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Glasgow, United Kingdom

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Leicester, United Kingdom

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Aligos Investigational Sites
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Sofia, Bulgaria

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Vancouver, Canada

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Beijing, China

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Guangzhou, China

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Shanghai, China

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Hong Kong, Hong Kong

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Bucharest, Romania

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Seoul, South Korea

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London, United Kingdom

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