New drug AK112 takes on standard immunotherapy in lung cancer showdown

NCT ID NCT05499390

First seen Mar 12, 2026 · Last updated May 08, 2026 · Updated 10 times

Summary

This phase 3 trial tests whether a new drug called AK112 works better than the standard immunotherapy pembrolizumab for people with advanced non-small cell lung cancer that has a specific marker (PD-L1). About 398 participants with stage IIIB/C or IV lung cancer will receive either AK112 or pembrolizumab as their first treatment. The main goal is to see which drug delays cancer growth longer, while also monitoring side effects and overall survival.

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Contacts and locations

Locations

  • Shanghai Pulmonary Hospital

    Shanghai, China

Conditions

Explore the condition pages connected to this study.