AI could slash contrast dye needed for brain scans
NCT ID NCT06224543
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether artificial intelligence (AI) software called SubtleGAD can enhance brain MRI images taken with a low dose of gadobutrol contrast dye, making them as clear as images taken with the standard higher dose. Sixty adults with known or suspected brain lesions received either a low dose (10% or 25% of standard) or the standard dose of contrast. The AI software was then used to improve the low-dose images. The goal is to see if this approach can reduce the amount of contrast dye patients need, potentially lowering risks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Gadobutrol (Gadavist) contrast agent
- What this could lead to
- If successful, this could allow patients to receive lower doses of contrast dye during brain MRIs, reducing potential risks while maintaining image quality.
- What could go wrong
- This is an early Phase 1 proof-of-concept study with only 60 participants. The AI-enhanced images may not match standard-dose quality in all cases, and results may not apply to all types of brain lesions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Central Illinois Radiological Associates; OSF St. Francis Hospital Peoria
Peoria, Illinois, 61637, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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The Pennsylvania State University
State College, Pennsylvania, 16801, United States
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UMass Chan Medical School
Worcester, Massachusetts, 01655, United States