New hope for ulcerative colitis: phase 3 trial of afimkibart underway
NCT ID NCT06589986
First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 34 times
Summary
This Phase 3 study is testing whether Afimkibart can help people with moderate-to-severe ulcerative colitis achieve remission. About 400 participants will receive either the drug or a placebo. The main goals are to see if symptoms improve by week 12 and if remission lasts through week 52.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ASST Rhodense - Ospedale di Rho
Rho, Lombardy, 20017, Italy
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Accelerium S. de R.L. de C.V.
Monterrey, Nuevo León, 64000, Mexico
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Access Research Institute
Brooksville, Florida, 34613, United States
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Addenbrookes Hospital
Cambridge, CB2 0QQ, United Kingdom
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Allied Biomedical Research Institute, Inc
Miami, Florida, 33155, United States
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Allied Gastrointestinal Associates, PA
Flowood, Mississippi, 39232, United States
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Allmedica Badania Kliniczne Sp z o.o. Sp K.
Nowy Targ, 34-400, Poland
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Amicis Research Center
Santa Clarita, California, 91355, United States
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Anhui Provincial Hospital
Hefei, 230001, China
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Aoyama Clinic;GI Endoscopy & IBD Center
Hyōgo, 650-0015, Japan
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Auzmer Research
Lakeland, Florida, 33813, United States
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BR Trials - Pesquisa Clínica
São Paulo, São Paulo, 03325-050, Brazil
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Barmherzige Brüder Wien
Vienna, 1020, Austria
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Baylor College of Medicine.
Houston, Texas, 77030, United States
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Binzhou Medical university hospital
Binzhou, China
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Boca Clinical Trials Mexico S.C. (Guadalajara)
Guadalajara, Jalisco, 44600, Mexico
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Borzan Polyclinic
Osijek, 31000, Croatia
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Boston University
Boston, Massachusetts, 02118, United States
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Brigham & Womens Hosp
Boston, Massachusetts, 02115, United States
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CH Dptal Les Oudairies
La Roche-sur-Yon, 85925, France
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CHC MontLégia
Liège, 4000, Belgium
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CHRU de Lille - Hopital Claude Huriez
Lille, 59037, France
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CHU Amiens - Hopital Sud
Amiens, 80054, France
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CHU Bordeaux - Hôpital Haut-Lévêque
Pessac, 33604, France
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CHU Dijon Bourgogne Hôpital François Mitterand
Dijon, 21000, France
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CHU Nice - Hopital de l'Archet 2
Nice, 06202, France
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CHU Saint Etienne - Hôpital Nord
Saint-Etienne, 42055, France
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CHU de Liège (Sart Tilman)
Liège, 4000, Belgium
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CHU de Rennes - Hopital de Pontchaillo
Rennes, 35033, France
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CIPREC Centro de Investigacion y Prevencion Cardiovascular
Ciudad Autonoma Buenos Aires, C1061AAS, Argentina
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CPQuali Pesquisa Clinica Ltda
São Paulo, São Paulo, 01228-000, Brazil
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Cantacuzino Clinical Hospital
Bucharest, 020475, Romania
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Carta - Clinical Associates In Research Therapeutics Of America;LLC
San Antonio, Texas, 78212, United States
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Centralny Szpital Kliniczny MSW w Warszawie
Warsaw, 02-507, Poland
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Centre Hospitalier Lyon Sud
Pierre-Bénite, 69495, France
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Centro Hospitalar de Entre Douro e Vouga - H. São Sebastião
Santa Maria da Feira, 4520-211, Portugal
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Centro Hospitalar do Algarve - Hospital de Portimao
Portimão, 8500-338, Portugal
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Centrum Medyczne "MEDYK"
Rzeszów, 35-326, Poland
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Centrum Medyczne "Medis"
Bydgoszcz, 85-229, Poland
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Centrum Medyczne Lukamed Joanna Luka-Wendrowska
Chojnice, 89-600, Poland
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Changhua Christian Medical Foundation Changhua Christian Hospital
Changhua, Changhua County, 50006, Taiwan
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Clinexpert Kft.
Budapest, 1033, Hungary
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Clinfan Szolgaltato Kft.
Szekszárd, 7100, Hungary
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Clinica Universidad de Los Andes
Santiago, Chile
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Clinical Center Kragujevac
Kragujevac, 34000, Serbia
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Clinical Center of Vojvodina
Novi Sad, 21137, Serbia
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Clinical Research of Osceola, LLC
Kissimmee, Florida, 34741, United States
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Clinical Trials UMED Sp. z o. o.
?ód?, 92-213, Poland
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Cliniq s.r.o.
Bratislava, 811 09, Slovakia
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Colentina Clinical Hospital
Bucharest, 020125, Romania
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Digestive Health Partners, PA
Asheville, North Carolina, 28801, United States
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Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan
Dothan, Alabama, 36305, United States
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Division of Gastroenterology, Depart of Internal Med, Siriraj H, Mahidol Uni
Bangkok, 10700, Thailand
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Division of Gastroenterology, Depart of Medicine, Fac of Med., Chulalongkorn University
Bangkok, 10330, Thailand
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Division of Gastroenterology, Depart of Medicine, Fac. of Med, Songklanagarind University
Songkhla, 90110, Thailand
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ETG Zamosc
Zamo??, 22-400, Poland
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Eminat Research Group
Miramar, Florida, 33027, United States
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Endo-Med Sp. z o.o.
Karczew, 05-480, Poland
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Endomed, s.r.o.
Košice, 040 01, Slovakia
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Expertia S.A- Mautalen Salud e Investigación
Ciudad Autonoma Buenos Aires, C1128AAE, Argentina
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Fiona Stanley Hospital
Murdoch, Western Australia, 6150, Australia
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Florida Medical Clinic
Zephyrhills, Florida, 33542, United States
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Florida Research Institute - Lakewood
Lakewood Rch, Florida, 34211, United States
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Fondazione IRCCS Policlinico San Matteo di Pavia
Pavia, Lombardy, 27100, Italy
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Fukuoka University Hospital
Fukuoka, 814-0180, Japan
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GI Alliance
Garland, Texas, 75044, United States
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GI Alliance - Southlake
Southlake, Texas, 76092, United States
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Gastro Florida
Clearwater, Florida, 33756, United States
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Gastro Intestinal Research Institute of Northern Ohio
Westlake, Ohio, 44145, United States
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Gastro One
Cordova, Tennessee, 38018, United States
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Gastroenterologie s.r.o.
Hradec Králové, 500 02, Czechia
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Gastroenterology Associates of Central Georgia
Macon, Georgia, 31201, United States
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Gastroenterology Consultants of SWVA
Roanoke, Virginia, 24018, United States
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Gastroenterology Health Partners, PLLC
New Albany, Indiana, 47150, United States
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Gastroenterology Health Partners, PLLC
Louisville, Kentucky, 40218, United States
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Gastrointestinal Associates of Northeast Tennessee
Johnson City, Tennessee, 37604, United States
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Gastromed Sp. z o.o.
Toru?, 87-100, Poland
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Gokeikai Ofuna Chuo Hospital
Kanagawa, 247-0056, Japan
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Grand Teton Research Group, PLLC
Idaho Falls, Idaho, 83404, United States
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Gujarat Gastro and Vascular Hospital
Surat, Gujarat, 395009, India
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Guy's Hospital
London, SE1 9RT, United Kingdom
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Hebei Medical University - The Second Hospital
Shijiazhuang, 050004, China
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Herlev Hospital
Herlev, 2730, Denmark
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Hidaka Coloproctology Clinic
Fukuoka, 839-0809, Japan
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Homestead Associates in Research, Inc.
Miami, Florida, 33033, United States
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Hopital Nord
Marseille, 13015, France
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Hopital Robert Debre
Reims, 51092, France
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Hospital General de Mexico
Mexico, Tlaxcala, 06726, Mexico
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Hospital Guillermo Grant Benavente
Concepción, 4030000, Chile
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Hospital Sao Teotonio
Viseu, 3504-509, Portugal
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Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
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Hospital Universitario Marques de Valdecilla
Santander, Cantabria, 39008, Spain
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Hospital da Luz Lisboa
Lisbon, 1500-650, Portugal
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Hospital de Braga
Braga, 4710-243, Portugal
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Hospital de Clinicas de Porto Alegre X
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Hospital de Sao Joao
Porto, 4202-451, Portugal
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Huizhou First Hospital
Huizhou, China
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Hôpital de Rangueil
Toulouse, 31400, France
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Indiana University Health University Hospital
Indianapolis, Indiana, 46202, United States
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Institut des MICI, Clinique Ambroise Paré
Neuilly-sur-Seine, 92200, France
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Intercity Gastroenterology
Fresh Meadows, New York, 11366, United States
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Ishida Clinic of IBD and Gastroenterology
Ōita, 870-0823, Japan
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J&A Clinical Research
Doral, Florida, 33126, United States
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JCHO Tokyo Yamate Medical Center
Tokyo, 169-0073, Japan
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Japanese Red Cross Takayama Hospital
Gifu, 506-8550, Japan
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Jinhua municipal central hospital
Jinhua, China
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Jávorszky Ödön Kórház
Vác, 2600, Hungary
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Kagawa Prefectural Central Hospital
Kagawa, 760-8557, Japan
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Kiepury Clinic
Sosnowiec, 41-200, Poland
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Kitasato University Kitasato Institute Hospital
Tokyo, 108-8642, Japan
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Las Vegas Clinical Trials, LLC
North Las Vegas, Nevada, 89030, United States
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Liver Research Unit, Srinagarind Hospital
Khon Kaen, 40002, Thailand
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Louisiana Research Center - GastroIntestinal Associates
Shreveport, Louisiana, 71105, United States
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Lyell McEwin Hospital
Adelaide, South Australia, 5112, Australia
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MHAT St. Ivan Rilski
Gorna Oryahovitsa, 5100, Bulgaria
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Mainstreet - Richmond Hill Clinic
Richmond Hill, New York, 11418, United States
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Mater Misericordiae Limited
South Brisbane, Queensland, 4101, Australia
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Matsuda Hospital
Shizuoka, 432-8061, Japan
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Medical University of South Carolina (MUSC)
Charleston, South Carolina, 29425, United States
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Medizinische Universität Innsbruck
Innsbruck, 6020, Austria
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Medwal
Santiago, Chile
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Melita Medical
Wroclaw, 53-611, Poland
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Miami Beach Clinical Research Center
Miami Beach, Florida, 33141, United States
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Michigan Center of Medical Research
Farmington Hills, Michigan, 48334, United States
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Monroe Biomedical Research
Monroe, North Carolina, 28112, United States
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Nagasaki University Hospital
Nagasaki, 852-8501, Japan
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Nanjing 1st Hospital
Nanjing, 210006, China
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National Hospital Organization Osaka National Hospital
Osaka, 540-0006, Japan
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National Hospital Organization Shizuoka Medical Center
Shizuoka, 411-8611, Japan
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National Taiwan University Hospital
Taipei, Zhongzheng District, 100, Taiwan
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Nemocnice Ceske Budejovice a.s.
České Budějovice, 370 01, Czechia
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Nodal Medical Center, LLC
Tampa, Florida, 33607, United States
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Obudai Egeszsegugyi Centrum Kft.
Budapest, 1036, Hungary
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Ohio Gastroenterology Group
Columbus, Ohio, 43202, United States
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Om Research LLC
Lancaster, California, 93534, United States
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Ospedale Madonna delle Grazie
Matera, Basilicate, 75100, Italy
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Pannonia Maganorvosi Centrum
Budapest, 1136, Hungary
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Peak Gastroenterology Associates
Colorado Springs, Colorado, 80907, United States
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Peking University Shenzhen Hospital
Shenzhen, 518036, China
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Peking University Third Hospital
Beijing, 100191, China
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Penta Hospitals Przychodnie, Wroclaw Wejherowska
Wroc?aw, 54-239, Poland
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Peters Medical Research (PMR), LLC
High Point, North Carolina, 27260, United States
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Pioneer Clinical Research NY
New York, New York, 10016, United States
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Policlinico Universitario Agostino Gemelli
Rome, Lazio, 00168, Italy
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Ren Min Hospital Affiliated Wu Han University
Wuhan, 430060, China
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Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, 200127, China
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Robley Rex VA Medical Center
Louisville, Kentucky, 40206, United States
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Royal Liverpool University Hospital
Liverpool, L7 8XP, United Kingdom
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Royal Prince Alfred Hospital
Sydney, New South Wales, 2050, Australia
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SOLUMED Centrum Medyczne
Późna, 60-529, Poland
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SPZOZ w ??cznej
??czna, 21-010, Poland
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SR Kalla Memorial Gastro & General Hospital
Jaipur, Rajasthan, 302006, India
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Saga University Hospital
Saga, 849-8501, Japan
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Saga-ken Medical Centre Koseikan
Saga, 840-8571, Japan
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Sameshima Hospital
Kagoshima, 892-0846, Japan
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Shaare Zedek Medical Center
Jerusalem, Bayit Vegan, 9103102, Israel
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Sichuan Provincial People's Hospital
Chengdu, 610072, China
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South Edmonton Gastroenterology
Edmonton, Alberta, T6K 4B2, Canada
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Southern Star Research Institute, LLC.
San Antonio, Texas, 78229, United States
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SurGal Clinic s.r.o.
Brno, 602 00, Czechia
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Surat Institute of Digestive Sciences Hospitals
Surat, Gujarat, 395002, India
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Surin hospital
Surin, 32000, Thailand
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TDDC dba GI Alliance Research
Mansfield, Texas, 76063, United States
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Texas Digestive Disease Consultants - Cedar Park
Cedar Park, Texas, 78613, United States
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Thammasat University Hospital
Pathum Thani, 12120, Thailand
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The 1st Affiliated Hospital of Nanchang Unversity
Nanchang, 330006, China
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The Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
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The First Affiliated Hospital Of Fujian Medical University
Fuzhou, 350005, China
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The First Affiliated Hospital of Anhui Medical University
Hefei, 230022, China
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The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, 510080, China
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The Second Affiliated Hospital of Xi'an Jiao Tong University
Xi'an, 710004, China
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The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, China
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The University of Chicago
Chicago, Illinois, 60637, United States
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The University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75390, United States
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The sixth affiliated hospital of Sun Yat-Sen University
Guangzhou, 510655, China
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Theia Clinical Research Centers, LLC
Tampa, Florida, 33613, United States
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Tianjin Medical University General Hospital
Tianjin, 300052, China
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Tidewater Gastroenterology Pllc T/A Gastro. Assoc. of Tidewater
Chesapeake, Virginia, 23320, United States
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Tokai University Hachioji Hospital
Tokyo, 192-0032, Japan
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Tri-State Gastroenterology Associates
Crestview Hills, Kentucky, 41017-3409, United States
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Tsujinaka Hospital Kashiwanoha
Chiba, 277-0871, Japan
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Tyler Research Institute, LLC
Tyler, Texas, 75701, United States
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Univ of Wisconsin Hosp & Clin
Madison, Wisconsin, 53792, United States
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Universita'degli Studi di Napoli Federico II
Naples, Campania, 80131, Italy
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Universitaetsklinikum Jena
Jena, 77430, Germany
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University Gastroenterology
Providence, Rhode Island, 02904, United States
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University Hospital Center Dr Dragisa Misovic - Dedinje
Belgrade, 11040, Serbia
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University Hospital Medical Center Bezanijska Kosa
Belgrade, 11080, Serbia
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University Hospital Medical Center Zvezdara
Belgrade, 11120, Serbia
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University of California Irvine
Orange, California, 92868, United States
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University of Texas Health Center at Tyler
Tyler, Texas, 75708, United States
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Vistamed & Vertigo Spó?Ka Z Ograniczon? Odpowiedzialno?Ci?
Wroc?aw, 53-149, Poland
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WIP Warsaw IBD Point Profesor Kierkus
Warsaw, 04-501, Poland
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Wojewodzki Specjalistyczny Szpital w Olsztynie
Olsztyn, 10-561, Poland
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Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology
Wuhan, 430022, China
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Wuxi People's Hospital
Wuxi, 214023, China
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Yokohama City University Medical Center
Yokohama, 232-0024, Japan
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Zhuzhou Central Hospital
Zhuzhou, China
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the First Hospital of Jilin University
Changchun, 130021, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Afimkibart (also known as PF-06480605, RVT-3101, RG6631, RO7790121)
What this could lead to
If successful, Afimkibart could offer a new treatment option to help people with moderate-to-severe ulcerative colitis achieve and maintain remission.
What could go wrong
This is a Phase 3 trial, but results are not yet available. The drug may not prove more effective than placebo, and side effects are possible. It is not a cure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.