New lupus drug afimetoran enters Mid-Stage trial

NCT ID NCT04895696

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether the drug afimetoran can safely control active systemic lupus erythematosus (SLE) better than a placebo. About 268 participants with lupus will receive either afimetoran or a placebo for 48 weeks, with an extension period allowing placebo users to switch to the drug. The goal is to see if afimetoran reduces lupus symptoms and disease activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Afimetoran (also known as BMS-986256)
What this could lead to: If successful, afimetoran could offer a new treatment option to better control lupus symptoms and reduce disease activity.
What could go wrong: This is a mid-stage trial with a moderate number of participants. The drug may not prove more effective than placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

autoimmune disease connective tissue disorder immune system disorder systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

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Locations

Local Institution - 0001

Barranquilla, 080020, Colombia
Local Institution - 0003

Zipaquirá, 250252, Colombia
Local Institution - 0004

Bogotá, 110221, Colombia
Local Institution - 0005

Chía, 250001, Colombia
Local Institution - 0006

Salvador, Estado de Bahia, 40150-150, Brazil
Local Institution - 0007

Porto Alegre, Rio Grande do Sul, 90480-000, Brazil
Local Institution - 0008

Juiz de Fora, Minas Gerais, 36010-570, Brazil
Local Institution - 0009

São Paulo, 04266-010, Brazil
Local Institution - 0010

Curitiba, Paraná, 80030110, Brazil
Local Institution - 0014

São Bernardo do Campo, São Paulo, 09715-090, Brazil
Local Institution - 0017

Guadalajara, Jalisco, 44650, Mexico
Local Institution - 0018

Mexico City, Mexico City, 11850, Mexico
Local Institution - 0020

León, Guanajuato, 37000, Mexico
Local Institution - 0021

Chihuahua City, 31210, Mexico
Local Institution - 0022

Zapopan, Jalisco, 45070, Mexico
Local Institution - 0025

Córdoba, Córdoba Province, 5004, Argentina
Local Institution - 0027

San Miguel de Tucumán, Tucumán Province, T4000, Argentina
Local Institution - 0029

Mesquite, Texas, 75150, United States
Local Institution - 0031

Salvador, Estado de Bahia, 41820-020, Brazil
Local Institution - 0037

San Juan, 00917, Puerto Rico
Local Institution - 0040

CABA, Distrito Federal, 1406, Argentina
Local Institution - 0041

San Juan, 5400, Argentina
Local Institution - 0042

Middleburg Heights, Ohio, 44130, United States
Local Institution - 0043

Santiago, Santiago Metropolitan, 7501126, Chile
Local Institution - 0044

Strasbourg, 67098, France
Local Institution - 0045

São José do Rio Preto, São Paulo, 15090000, Brazil
Local Institution - 0048

Bordeaux, 33076, France
Local Institution - 0049

Poznan, 60-218, Poland
Local Institution - 0052

Wroclaw, 50-556, Poland
Local Institution - 0055

Madrid, 28009, Spain
Local Institution - 0056

A Coruña, 15006, Spain
Local Institution - 0057

Seville, 41014, Spain
Local Institution - 0058

Barcelona, 08035, Spain
Local Institution - 0060

Mexico City, Mexico City, 06760, Mexico
Local Institution - 0061

Mérida, 97070, Mexico
Local Institution - 0062

Camberwell, Victoria, 3124, Australia
Local Institution - 0063

Botany, New South Wales, 2019, Australia
Local Institution - 0064

Ivanhoe, Victoria, 3079, Australia
Local Institution - 0065

Woodville, South Australia, 5011, Australia
Local Institution - 0066

Maroochydore, Queensland, 4558, Australia
Local Institution - 0067

Bucharest, 011172, Romania
Local Institution - 0068

Giroc, 307220, Romania
Local Institution - 0070

Eagan, Minnesota, 55121, United States
Local Institution - 0071

Monterrey, Nuevo León, 64000, Mexico
Local Institution - 0072

Westmead, New South Wales, 2145, Australia
Local Institution - 0073

Santiago, Santiago Metropolitan, 0, Chile
Local Institution - 0074

Buenos Aires, Distrito Federal, C1121ABE, Argentina
Local Institution - 0075

Providencia, Santiago Metropolitan, 7500504, Chile
Local Institution - 0076

Cali, 760042, Colombia
Local Institution - 0077

Taipei, 11217, Taiwan
Local Institution - 0078

Taichung, 407, Taiwan
Local Institution - 0079

Taipei, 10002, Taiwan
Local Institution - 0080

Kaohsiung Niao Sung Dist, 83301, Taiwan
Local Institution - 0081

Taichung, 404, Taiwan
Local Institution - 0082

Râmnicu Vâlcea, Vâlcea County, 247065, Romania
Local Institution - 0083

Brest, Finistère, 29609, France
Local Institution - 0084

Freiburg im Breisgau, 79106, Germany
Local Institution - 0085

Berlin, 10117, Germany
Local Institution - 0086

Essen, 45122, Germany
Local Institution - 0087

Cologne, North Rhine-Westphalia, 50937, Germany
Local Institution - 0091

Las Vegas, Nevada, 89128, United States
Local Institution - 0093

Cuiabá, Mato Grosso, 78020-500, Brazil
Local Institution - 0095

Kitakyushu, Fukuoka, 807-8556, Japan
Local Institution - 0096

Sapporo, Hokkaido, 060-8648, Japan
Local Institution - 0097

Tokyo, 104-8560, Japan
Local Institution - 0098

Shinjuku-ku, Tokyo, 1600035, Japan
Local Institution - 0099

Sendai, Miyagi, 980-8574, Japan
Local Institution - 0100

Birmingham, Alabama, 35205, United States
Local Institution - 0103

Charlotte, North Carolina, 28211, United States
Local Institution - 0104

Kanazawa, Ishikawa-ken, 920-8641, Japan
Local Institution - 0105

Shinjuku-ku, Tokyo, 1628655, Japan
Local Institution - 0106

Dublin, D15 X40D, Ireland
Local Institution - 0107

Galway, H91 TY80, Ireland
Local Institution - 0110

Bradford, BD5 0NA, United Kingdom
Local Institution - 0111

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom
Local Institution - 0112

Marseille, 13003, France
Local Institution - 0113

Itabashiku, Tokyo, 173-8610, Japan
Local Institution - 0114

Eiheiji-cho,Yoshida-gun, Fukui, 910-1193, Japan
Local Institution - 0115

Chiba, 260-8712, Japan
Local Institution - 0116

Tokyo, 113-8654, Japan
Local Institution - 0117

Bunkyo-ku, Tokyo, 1138431, Japan
Local Institution - 0119

Manorhamilton, Leitrim, 0, Ireland
Local Institution - 0121

Clearwater, Florida, 33765, United States
Local Institution - 0122

Orlando, Florida, 32808, United States
Local Institution - 0123

Huntington Beach, California, 92648, United States
Local Institution - 0124

St Louis, Missouri, 63110, United States
Local Institution - 0125

Manchester, M13 9WL, United Kingdom
Local Institution - 0127

Osorno, Los Lagos Region, 5290000, Chile
Local Institution - 0128

Buenos Aires, C1426ABP, Argentina
Local Institution - 0129

Lille, 59037, France
Local Institution - 0130

Quilmes, Buenos Aires, 1878, Argentina
Local Institution - 0132

The Bronx, New York, 10461, United States
Local Institution - 0134

Wheaton, Maryland, 20902, United States
Local Institution - 0136

Amarillo, Texas, 79124, United States
Local Institution - 0137

South Miami, Florida, 33143, United States
Local Institution - 0138

Aichi, 457-8511, Japan
Local Institution - 0140

Manhasset, New York, 11030, United States
Local Institution - 0143

Valdivia, Los Ríos Region, 2279374, Chile
Local Institution - 0144

Caen, 14033, France
Local Institution - 0146

Orland Park, Illinois, 60467, United States
Local Institution - 0149

Warsaw, 00-874, Poland
Local Institution - 0150

Meguro-ku, Tokyo, 1538515, Japan
Local Institution - 0151

Columbus, Ohio, 43203, United States
Local Institution - 0152

Allen, Texas, 75013, United States
Local Institution - 0154

Plantation, Florida, 33324, United States
Local Institution - 0155

Tamarac, Florida, 33321, United States
Local Institution - 0156

Pessac, Aquitaine, 33600, France
Local Institution - 0157

Bucharest, 011053, Romania
Local Institution - 0158

Mexico City, 14080, Mexico
Local Institution - 0159

La Palma, California, 90623, United States
Local Institution - 0160

Atlanta, Georgia, 30318, United States
Local Institution - 0162

Fukushima, 960-1295, Japan
Local Institution - 0163

San Antonio, Texas, 78215, United States
Local Institution - 0164

Woodland Hills, California, 91364, United States
Local Institution - 0165

St Louis, Missouri, 63141, United States
Local Institution - 0167

Kissimmee, Florida, 34741, United States
Local Institution - 0170

La Jolla, California, 92037, United States
Local Institution - 0171

Baton Rouge, Louisiana, 70836, United States
Local Institution - 0172

San Diego, California, 92128, United States
Local Institution - 0173

Ormond Beach, Florida, 32174, United States
Local Institution - 0174

Changchun, Jilin, 130000, China
Local Institution - 0176

Nanjing, Jiangsu, 210000, China
Local Institution - 0177

Beijing, Beijing Municipality, 100029, China
Local Institution - 0178

Jinan, Shandong, 250012, China
Local Institution - 0179

Dalian, Liaoning, 116023, China
Local Institution - 0180

Beijing, Beijing Municipality, 100144, China
Local Institution - 0183

Jining, Shandong, 272011, China
Local Institution - 0184

Shenzhen, Guangdong, 518107, China
Local Institution - 0187

Hopkinsville, Kentucky, 42240, United States
Local Institution - 0188

Nanjing, Jiangsu, 210029, China
Local Institution - 0190

Medellín, Antioquia, 050021, Colombia
Local Institution - 0193

Suzhou, Jiangsu, 215006, China
Local Institution - 0195

San Fernando, Buenos Aires, 1646, Argentina
Local Institution - 0197

Allen, Texas, 75013, United States
Local Institution - 0203

Charlotte, North Carolina, 28204, United States
Local Institution - 0204

Warsaw, Masovian Voivodeship, 02-665, Poland
Local Institution - 0205

Suwanee, Georgia, 30024, United States
Local Institution - 0206

Santander, Cantabria, 39008, Spain
Local Institution - 0207

Buenos Aires, 1425, Argentina
Local Institution - 0208

New Delhi, National Capital Territory of Delhi, 110029, India
Local Institution - 0209

Secunderabad, Telangana, 500003, India
Local Institution - 0210

Bengaluru, Karnataka, 560010, India
Local Institution - 0214

Gurugram, Haryana, 122001, India
Local Institution - 0218

Fuchū, Tokyo, 1838524, Japan
Local Institution - 0219

West Long Branch, New Jersey, 07764, United States
Local Institution - 0223

Bellevue, Washington, 98004, United States
Local Institution - 0226

Ahmedabad, Gujarat, 380015, India

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