Major heart drug trial aims to ease strain for thousands

NCT ID NCT06081894

Summary

This large, late-stage study is testing whether a new drug called aficamten can improve quality of life and exercise ability for adults with a specific heart condition where the heart muscle is too thick but not blocked. It will compare the drug to a placebo in 500 participants to see if it helps people feel better, exercise more, and reduces serious heart-related problems.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • "Hippokration" General Hospital of Athens

    Athens, 11527, Greece

  • Aarhus University Hospital

    Aarhus, 8200, Denmark

  • Amsterdam UMC, location AMC

    Amsterdam, 1105, Netherlands

  • Ascension Saint Thomas Heart West

    Nashville, Tennessee, 37205, United States

  • Ascension St. Vincent

    Indianapolis, Indiana, 46260, United States

  • Assistance Publique Hopitaux De Paris

    Paris, 75010, France

  • Assistance Publique Hopitaux de Marseille

    Marseille, 13005, France

  • Assistance Publique Hopitaux de Paris

    Paris, 75015, France

  • Associacao Lar Sao Francisco de Assis na Providencia de Deus - Hospital Universitario Sao Francisco na Providencia de Deus (HUSF)

    São Paulo, 12916-542, Brazil

  • Aurora St. Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Azienda Ospedaliera Universitaria Careggi pad. 13 Clinica Medica II Plano Cardiologia

    Florence, 50134, Italy

  • Azienda Sanitaria Universitaria Giuliano Isontina Trieste SC Cardiologia

    Trieste, 34148, Italy

  • Barts Health NHS Trust St Bartholomew's Hospital

    London, EC1A 7BE, United Kingdom

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • CLINICOR Clinica Cardiologica LTDA

    Ribeirão Preto, 14026-900, Brazil

  • Cardiologia Universitaria - UTIC - Riabilitazione Cardiologica Azienda Ospedaliero Universitaria - Ospedali Riuniti

    Foggia, 71122, Italy

  • Cardiology Department IRCCS San Donato Hospital - University of Milan

    San Donato Milanese, Milano, 20097, Italy

  • Carilion Clinic Cardiology

    Roanoke, Virginia, 24014, United States

  • Cedars-Sinai Medical Center (Smidt Heart Institute)

    Los Angeles, California, 90048, United States

  • Centre Hospitalier Universitaire De Bordeaux

    Pessac, 33600, France

  • Centre Hospitalier Universitaire De Montpellier

    Montpellier, 34295, France

  • Centre Hospitalier Universitaire De Nantes

    Saint-Herblain, 44800, France

  • Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum (CVK) Medizinische Klinik mit Schwerpunkt Kardiologie

    Berlin, 13353, Germany

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinique Du Millenaire

    Montpellier, 34000, France

  • Columbia University Medical Center/New York Presbyterian Hospital

    New York, New York, 10032, United States

  • Complejo Hospitalario Universitario A Coruna

    A Coruña, 15006, Spain

  • Department of Cardiology Copenhagen University Hospital, Bispebjerg

    Copenhagen, 2400, Denmark

  • Dipartimento Cardio-toraco- vascolare, ASST Grande Ospedale Metropolitano, NiguardaPiazza Ospedale Maggiore, 3

    Milan, 20162, Italy

  • Dipartimento Cardiopolmonare, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

    Roma, 00163, Italy

  • Dipartimento di Emergenze Cardiovascolari, Medicina Clinica e dell'Invecchiamento, AOU Federico II

    Naples, 80131, Italy

  • Division of Cardiology Hadassah Medical Center

    Jerusalem, 9112001, Israel

  • Emory Clinic

    Atlanta, Georgia, 30322, United States

  • Erasmus University Medical Center

    Rotterdam, 3015, Netherlands

  • Evangelismos General Hospital of Athens

    Athens, 10676, Greece

  • Fiona Stanley Hospital, AHF Unit

    Murdoch, 6150, Australia

  • Flinders Medical Centre Cardiology Research

    Adelaide, South Australia, 5042, Australia

  • Fondazione Toscana Gabriele Monasterio Per La ricerca Medica e Di Sanita Pubbliga (FTGM) Cardio-Toracic-UOC Cardiology and Cardiovasulcar Medicine San Cataldo Hospital at CNR

    Pisa, 56124, Italy

  • Fundacao Felice Rocho / Hospital Felicio Rocho

    Minas Gerais, 30110-934, Brazil

  • Fuwai Hospital, CAMS & PUMC

    Beijing, 100037, China

  • Greenville Memorial Hospital

    Greenville, South Carolina, 29605-5601, United States

  • Guangdong Provincial People's Hospital

    Guangzhou, 519041, China

  • Hamamatsu University Hospital

    Shizuoka, 431-3192, Japan

  • Health Sciences North

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Herzzentrum der Universitatsmedizin Gottingen

    Göttingen, 37075, Germany

  • Holy Cross Medical Group - Cardiology Associates

    Fort Lauderdale, Florida, 33308, United States

  • Hopital Rangueil

    Toulouse, 31059, France

  • Hospital Alvaro Cunqueiro

    Vigo, 36312, Spain

  • Hospital CUF Descobertas, Lisbon, Cadiology Department

    Lisbon, 1998-018, Portugal

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Clinico Universitario Virgen de la

    Murcia, 30120, Spain

  • Hospital General Universitario Gregorio Marañón (HGUGM), Calle del Doctor Esquerdo, 46.

    Madrid, 28007, Spain

  • Hospital Italiano de Buenos Aires Juan Domingo Peron

    Buenos Aires, 119, Argentina

  • Hospital Privado Centro Medico de Cordoba S.A

    Córdoba, X5016KEH, Argentina

  • Hospital Son Llatzer

    Palma de Mallorca, 07198, Spain

  • Hospital Universitario Puerta de Hierro

    Madrid, 28220, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital Universitario Virgen de la Victoria Campus Universitario de Teatinos

    Málaga, 29010, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hospital da Luz

    Lisbon, 1500-650, Portugal

  • Hospital das Clinicas de Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo - HCFMRP

    São Paulo, 14051-140, Brazil

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08025, Spain

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Hyogo Prefectural Harima-Himeii General Medical Center

    Hyōgo, 670-8560, Japan

  • ICBA - Instituto Cardiovascular de Buenos Aires

    Buenos Aires, C1428, Argentina

  • Inova Health Care Services

    Falls Church, Virginia, 22042, United States

  • Instituto D'Or de Pesquisa e Ensino/Cardio Pulmonar da Bahia SA

    Ondina, Salvador, 40170-0130, Brazil

  • Instituto Dante Pazzanese de Cardiologia

    São Paulo, 04012-909, Brazil

  • Instituto do Coracao do Hospital de Aguiar

    São Paulo, 05403-900, Brazil

  • Intermountain Medical Center

    Murray, Utah, 84107, United States

  • Investigational Drug Services, AdventHealth Orlando

    Orlando, Florida, 32804, United States

  • Kardio Brynow Sp. z o.o.

    Katowice, 40-555, Poland

  • Keck Medical Center of USC (Outpatient Clinic)

    Los Angeles, California, 90033, United States

  • Kitasato University Hospital

    Sagamihara, 252-0375, Japan

  • Kobe City Medical Center General Hospital

    Hyōgo, 650{047, Japan

  • Kochi Medical School Hospital

    Kochi, 783-8505, Japan

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Lahey Hospital & Medical Center

    Burlington, Massachusetts, 01803, United States

  • Landspitali University Hospital

    Reykjavik, 101, Iceland

  • Liverpool Heart and Chest Hospital NHS Foundation Trust

    Liverpool, L14 3PE, United Kingdom

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • M Health Fairview University of Minnesota Medical Center - East Bank

    Minneapolis, Minnesota, 55455, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • MedStar Union Memorial Hospital

    Baltimore, Maryland, 21218, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medical College of Wisconsin/Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Meir Medical Center

    Kfar Saba, 4428164, Israel

  • Michigan Medicine

    Ann Arbor, Michigan, 48109, United States

  • Mie University Hospital

    Mie, 514-8507, Japan

  • Montreal Heart Institute

    Montreal, Quebec, H1T 1C8, Canada

  • Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • NHS Greater Glasgow and Clyde Queen Elizabeth University Hospital

    Glasgow, G51 4TF, United Kingdom

  • NHS Tayside Ninewells Hospital & Medical School

    Dundee, Scotland, DD1 9SY, United Kingdom

  • NUPEC Cardio / Cardio HVC

    Minas Gerais, 30220-140, Brazil

  • NYU Langone Health

    New York, New York, 10016, United States

  • National Cerebral and Cardiovascular Center

    Osaka, 564-8565, Japan

  • National Hospital Organization Kyoto Medical Center

    Kyoto, 612-0861, Japan

  • National University Corporation Tohoku University Tohoku University Hospital

    Miyagi, 980-8574, Japan

  • Nippon Medical School Hospital

    Tokyo, 113-8603, Japan

  • Northwell Health North Shore University Hospital

    Manhasset, New York, 11030, United States

  • Northwestern University

    Evanston, Illinois, 60208, United States

  • Odense University Hospital, Department of Cardiology

    Odense, 5000, Denmark

  • Onassis Cardiac Surgery Center

    Kallithea, 17674, Greece

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Osaka General Medical Center

    Osaka, 558-8558, Japan

  • Osaka Medical and Pharmaceutical University Hospital

    Osaka, 569-8686, Japan

  • Osaka Metropolitan University Hospital

    Osaka, 545-8586, Japan

  • Oxford Centre for Clinical Magnetic Resonance Research (Ocmr)

    Oxford, OX3 9DU, United Kingdom

  • P. Debyelaan 25

    Maastricht, HX, 6229, Netherlands

  • Peking University First Hospital

    Beijing, 100034, China

  • People's Hospital of Liaoning Province

    Shenyang, 110067, China

  • Piedmont Heart Institute (CPET)

    Fayetteville, Georgia, 30214, United States

  • Providence Sacred Heart Medical Center & Children's Hospital (CPET)

    Spokane, Washington, 99204, United States

  • Providence St. Vincent Medical Center

    Portland, Oregon, 97225, United States

  • QEII Health Science Centre (Halifax Infirmary site)

    Halifax, B3H 3A7, Canada

  • Remin Hospital of Wuhan University

    Wuhan, 430060, China

  • Royal Alexandra Hospital

    Edmonton, Alberta, T5H 3V9, Canada

  • Royal Brompton Hospital

    London, SW3 6NP, United Kingdom

  • SHOWA Medical University Fujigaoka Hospital

    Kanagawa, 227-8501, Japan

  • Saint Luke's Hospital of Kansas City

    Kansas City, Missouri, 64111, United States

  • Saitama Medical University International Medical Center

    Saitama, 350-1298, Japan

  • Sanger Heart & Vascular Institute - HCM Clinic

    Charlotte, North Carolina, 28204, United States

  • Saraiva & Berlinger LTDA - EPP/IPECC - Instituto de Pesquisa Clinical de Campinas

    São Paulo, 13060-080, Brazil

  • Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika

    Budapest, 1122, Hungary

  • Shanghai Ruijin Hospital Luwan Branch

    Shanghai, 200020, China

  • Shinshu University Hospital

    Nagano, 390-8621, Japan

  • St George's University Hospitals NHS Foundation Trust,

    London, SW17 0QT, United Kingdom

  • St. Boniface Hospital

    Winnipeg, Manitoba, R2H 2A6, Canada

  • St. Luke's International Hospital

    Tokyo, 104-8560, Japan

  • Teikyo University Hospital

    Tokyo, 173-8606, Japan

  • The 1st Affiliated Hospital of Sun Yat-sen University

    Guangzhou, Guangdong, 510080, China

  • The 1st affi. Hospital of Xi'an Jiaotong University

    Xi'an, 710061, China

  • The 1st affiliated Hospital of Zhengzhou University

    Zhenzhou, 450052, China

  • The Barzilai University Medical Center 2 - Cardiology Division

    Ashkelon, 7830604, Israel

  • The Chaim Sheba Medical Center

    Ramat Gan, 5265601, Israel

  • The First Hospital of Jilin University

    Jilin, 130031, China

  • The Lindner Research Center at The Christ Hospital

    Cincinnati, Ohio, 45219, United States

  • The Prince Charles Hospital

    Chermside, Queensland, 4032, Australia

  • The Queen's Medical Center-Punchbowl

    Honolulu, Hawaii, 96813, United States

  • The University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • The University of Tokyo Hospital

    Tokyo, 113-8655, Japan

  • Tokyo Women's Medical University Hospital

    Tokyo, 162-8666, Japan

  • UC San Diego Health - Sulpizio Cardiovascular Center

    La Jolla, California, 92037, United States

  • UCLA Medical Center Cardiovascular Clinic

    Los Angeles, California, 90095, United States

  • UOC Cardiologica

    Brescia, 25123, Italy

  • UPMC Presbyterian

    Pittsburgh, Pennsylvania, 15213, United States

  • Unidade Local de Saude da Regiao de Aveiro, E.P.E.

    Aveiro, 3814-501, Portugal

  • Unidade Local de Saude de Sao Jose, E.P.E, - Hospital de Santa Marta Servico de Cardiologia

    Lisbon, 1150-199, Portugal

  • Unidade Local de Saude do Alto Ave, E.P.E

    Creixomil, Guimaraes, 4835-044, Portugal

  • Unita Operativa di Riabilitazione Cardiologica, Istituto Auxologico Italiano, IRCCS - Auxologico San Luca, Piazzale Brescia, 20

    Milan, 20149, Italy

  • Univeristy Hospital Jena Clinic for Internal Medicine I (Cardiology, Angiology, Internal Intensive Care Medicine)

    Jena, 07747, Germany

  • Universitaesklinkum Heidelberg Klinik fuer Kardiologie, Angeiologie und Pneumologie

    Heidelberg, 69120, Germany

  • University General Hospital Attikon

    Attiki, 12462, Greece

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Szeged

    Szeged, 6725, Hungary

  • University of Tsukuba Hospital

    Ibaraki, 305-8576, Japan

  • University of Utah Health

    Salt Lake City, Utah, 84132, United States

  • University of Virginia

    Charlottesville, Virginia, 22903, United States

  • University of Wisconsin Hospitals and Clinics

    Madison, Wisconsin, 53792, United States

  • VCU Health Downtown Medical Campus

    Richmond, Virginia, 23298, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Virginia Mason Medical Center

    Seattle, Washington, 98101, United States

  • WVU Medicine

    Morgantown, West Virginia, 26506, United States

  • Weill Cornell Medicine

    New York, New York, 10021, United States

  • Westchester Medical Center

    Valhalla, New York, 10595, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 06519, United States

  • Zhongda Hospital Southeast University

    Nanjin, 210009, China

  • Zhongshan Hospital Fudan University

    Shanghai, 200032, China

  • Ziv Medical Center

    Safed, 1311001, Israel

Conditions

Explore the condition pages connected to this study.