New heart drug shows promise in major trial for debilitating condition

NCT ID NCT05186818

Summary

This study tested whether a new oral drug called aficamten could help adults with a specific heart condition where the heart muscle is too thick, causing symptoms like shortness of breath and limiting exercise. Over 280 participants took either the drug or a placebo pill daily for 24 weeks. The main goal was to see if the drug could safely improve how much exercise people could do and reduce their symptoms.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (OHCM) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • Aalborg University Hospital, Department of Cardiology

    Aalborg, 9100, Denmark

  • Alaska Heart and Vascular Institute

    Anchorage, Alaska, 99508, United States

  • Amsterdam UMC, location AMC

    Amsterdam, 1105, Netherlands

  • Ascension St. John Clinical Research Institute

    Tulsa, Oklahoma, 74104, United States

  • Azienda Ospedaliero Universitaria Careggi Dipartimento Cardiotoracovascolare - Cardiomiopatie Unit

    Florence, 50134, Italy

  • Barts Health NS Trust

    London, EC1A 7BE, United Kingdom

  • Beijing Anzhen Hospital

    Beijing, Beijing Municipality, 100029, China

  • Beijing Chao-Yang Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100020, China

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • CHU Pitie-Salpetriere, Centre de reference maladies cardiaques hereditaires ou rares

    Paris, France

  • CHU de Bordeaux Hopital Cardiologique Haut-Leveque

    Pessac, 33600, France

  • CHU de Marseille - Hopital de la Timone Service de cardiologie

    Marseille, 13005, France

  • CHU de Nantes

    Nantes, 44093, France

  • CHU du Haut Lveque Cardiologie

    Pessac, 33604, France

  • Cedars-Sinai Medical Center - Smidt Heart Institute Clinic

    Los Angeles, California, 90048, United States

  • Centro Hospitalar Do Baixo Vouga, EPE AV ARTUR RAVARA

    Aveiro, 3814-501, Portugal

  • Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum (CVK) Medizinische Klinik mit Schwerpunkt Kardiologie

    Berlin, 13353, Germany

  • Charles University

    Prague, 128 08, Czechia

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Columbia University Medical Center/NY Presbyterian Hospital

    New York, New York, 10032, United States

  • Complejo Hospitalario Universitario

    A Coruña, La Coruna, 15006, Spain

  • Copenhagen University Hospital

    Copenhagen, 2400, Denmark

  • Department of Cardiology Aarhus University Hospital

    Aarhus, 8200, Denmark

  • Dipartimento di Medicina Clinica e Molecolare Universita Sapienza di Roma Unita di Terapia Intensiva Cardiologica Azienda Ospedaliero Universitaria Sant'Andrea

    Roma, 1035-39, Italy

  • Duke Health Center Arringdon

    Morrisville, North Carolina, 27560, United States

  • Emory Clinic

    Atlanta, Georgia, 30322, United States

  • Erasmus Medical Center

    Rotterdam, 3015, Netherlands

  • Fondazione toscana Gabriele Monesterio per la ricarca medica Dipartimento Cardiotoracico UOC Cardiologia e Medicina Cardiovasculare Ospedale San Cataldo

    Pisa, 56124, Italy

  • Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Hadassah Medical Center- Ein Kerem

    Jerusalem, 9112001, Israel

  • Henry Ford Medical Center

    Detroit, Michigan, 48202, United States

  • Hjertecentret (The Heart Center)

    Copenhagen, 2100, Denmark

  • Holy Cross Hospital / Cardiology Associates

    Fort Lauderdale, Florida, 33308, United States

  • Hopital Lariboisiere, Service de Cardiologie

    Paris, 75010, France

  • Hopital Universitaire de Rangueil (CHU de Toulouse) Service de Cardiologie

    Toulouse, Cedex, 31059, France

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clinico Universitario Virgen de la Arrixaca

    Murcia, Spain

  • Hospital Universitario Puerta de Hierro

    Madrid, Majadahonda, Spain

  • Hospital Universitario Son Llatzer Secretaria de Cardiologia

    Palma, 07198, Spain

  • Hospital Universitario Virgen Macarena-merge

    Seville, 41009, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hospital da Luz

    Lisbon, 1500-650, Portugal

  • Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine)

    Philadelphia, Pennsylvania, 19104, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Hôpital Européen Georges Pompidou

    Paris, 75015, France

  • Interni klinika kardiologie a angiologie

    Prague, 12808, Czechia

  • Kaplan Medical Center

    Rehovot, 76100, Israel

  • Kardio Brynow S.C

    Katowice, Poland

  • Kerckhoff-Klinik GmbH Abteilung Administration Forschung und Lehre

    Bad Nauheim, 61231, Germany

  • Klinikumder Georg-August-Universitaet

    Göttingen, 37075, Germany

  • Krakowskie Centrum

    Krakow, Poland

  • Lahey Hospital & Medical Center

    Burlington, Massachusetts, 01805, United States

  • Liverpool Heart and Chest Hospital - Liverpool Heart and Chest Hospital NHS Foundation Trust- HWS Greater Glasgow and Clyde

    Liverpool, L14 3LB, United Kingdom

  • M Health Fairview University of Minnesota Medical Center - East Bank

    Minneapolis, Minnesota, 55455, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Mayo Clinic Florida

    Jacksonville, Florida, 32224, United States

  • MedStar Medical Group Cardiology at Union Memorial

    Baltimore, Maryland, 21218, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medstar Franklin Square Medical Center

    Baltimore, Maryland, 21237, United States

  • Michigan Medicine

    Ann Arbor, Michigan, 48109, United States

  • Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • NYU Langone Health

    New York, New York, 10016, United States

  • Nanfang Hospital Southern Medical University

    Guanzhou, Guangdong, 516006, China

  • Narodowy Instytut Kardiologii Stefana Kardynała Wyszynskiego- Panstwowy Instytut Badawczy

    Warsaw, Masovian Voivodeship, 04-628, Poland

  • Northwestern University

    Chicago, Illinois, 60614, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Oxford Centre for Clinical Magnetic Resonance Research

    Oxford, OX3 9DU, United Kingdom

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 10019, China

  • Piedmont Fayette Hospital

    Fayetteville, Georgia, 30214, United States

  • Queen Elizabeth Hospital Birmingham University Hospitals Birmingham NHS Foundation Trust

    Edgbaston, Birmingham, B15 2GW, United Kingdom

  • Queen Elizabeth University Hospital - HWS Greater Glasgow and Clyde

    Glasgow, G1 4TF, United Kingdom

  • Radcliffe Department of Medicine

    Oxford, OX3 9DU, United Kingdom

  • Royal Brompton Hospital

    London, SW3 6NP, United Kingdom

  • Saint Luke's Hospital of Kansas City

    Kansas City, Missouri, 64111, United States

  • Sanger Heart and Vascular Institute

    Charlotte, North Carolina, 10595, United States

  • Sanger Heart and Vascular Institute - HCM Clinic

    Charlotte, North Carolina, 28204, United States

  • Semmelweis Egyetem Varosmajori Sziv es Ergyogyasazati Klinika

    Budapest, Hungary

  • Spectrum Health Medical Group Cardiovascular Medicine

    Grand Rapids, Michigan, 49525, United States

  • St George's University Hospitals NHS Foundation Trust

    London, SW17 0QT, United Kingdom

  • Stanford University Hospital

    Stanford, California, 94305, United States

  • Stern Cardiovascular Foundation, Inc

    Germantown, Tennessee, 38138, United States

  • The Barzilai University Medical Center

    Ashkelon, 78100, Israel

  • The Barzilai University Medical Center

    Ashkelon, 7830604, Israel

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi’an, Shanxi, 710061, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450018, China

  • The First Hospital of Jinlin University

    Changchun, Jinlin, 130031, China

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • The Olga & Lev Leviev Heart Center The Chaim Sheba Medical Center

    Ramat Gan, Tel Hasomer, 5265601, Israel

  • The University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • UC San Diego Health - Sulpizio Cardiovascular Center

    La Jolla, California, 92037, United States

  • UOC Cardiologica Azienda Ospedaliera Spedali Civili di Brescia

    Brescia, 25123, Italy

  • UPMC Presbyterian

    Pittsburgh, Pennsylvania, 15213, United States

  • Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • Universitaetsklinikum Essen Westdeutsches Herz-Gefaesszentrum

    Essen, 45147, Germany

  • Universitaetsklinikum Heidelberg

    Heidelberg, Germany

  • Universitaetsklinikum Jena Klinik fuer Innere Medizin 1

    Jena, 07747, Germany

  • Universitaetsmedizin Goettingen

    Göttingen, 37075, Germany

  • University Hospital Maastricht

    Maastricht, 6229HX, Netherlands

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Utah Hospital

    Salt Lake City, Utah, 84132, United States

  • University of Virginia Health System University Hospital

    Charlottesville, Virginia, 22908, United States

  • University of Washington Medical

    Seattle, Washington, 98195, United States

  • Universitätsklinikum Würzburg

    Würzburg, Germany

  • Unniversitaetsklinikum Magdeburg Klinik fur Kardiologie und Anglologie

    Magdeburg, 39120, Germany

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Westchester Medical Center

    Valhalla, New York, 10595, United States

  • Xiangya Hospital of the Central South University

    Changsha, Hunan, 410008, China

  • Yale School of Medicine

    New Haven, Connecticut, 06511, United States

  • Yale University School of Medicine

    New Haven, Connecticut, 06519, United States

  • Ziv Medical Center

    Safed, 13100, Israel

Conditions

Explore the condition pages connected to this study.