New combo therapy shows promise against Tough-to-Treat uterine cancer
NCT ID NCT03517449
Summary
This large, completed Phase 3 trial tested whether a new combination of two drugs (lenvatinib and pembrolizumab) worked better than standard chemotherapy for women with advanced endometrial cancer that had worsened after initial treatment. The main goal was to see if the combination helped patients live longer and kept the cancer from growing for a longer time. Over 800 participants were randomly assigned to receive either the new drug combo or one of the standard chemotherapy options chosen by their doctor.
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Contacts and locations
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Locations
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Acibadem Bursa Hastanesi
Bursa, 16110, Turkey (Türkiye)
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Acibadem Universitesi Atakent Hastanesi
Istanbul, 34303, Turkey (Türkiye)
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Addenbrookes Hospital
Cambridge, CB2 0QQ, United Kingdom
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Alivia Clinica de Alta Especialidad S.A. de C.V.
Monterrey, Nuevo León, 64060, Mexico
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Altay Regional Oncology Dispensary
Barnaul, 656049, Russia
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Arizona Oncology Associates, PC- HAL
Phoenix, Arizona, 85016, United States
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Asan Medical Center
Seoul, 5505, South Korea
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Auckland City Hospital
Auckland, 1023, New Zealand
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Azienda Ospedaliera per l Emergenza Cannizzaro
Catania, 95126, Italy
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Barts Health NHS Trust - St Bartholomew s Hospital
London, EC1A 7BE, United Kingdom
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Basken Adana Dr.Turgut Noyan Uygulama ve Arastirma Merkezi
Adana, 01250, Turkey (Türkiye)
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Baskent Universitesi Ankara Hastanesi
Ankara, 06490, Turkey (Türkiye)
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Beskidzkie Centrum Onkologii im. Jana Pawla II
Bielsko-Biala, 43-300, Poland
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Biomelab S A S
Barranquilla, 08002, Colombia
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CHU de Quebec-Universite Laval-Hotel Dieu de Quebec
Québec, G1R 2J6, Canada
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CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont
Montreal, Quebec, H1T 2M4, Canada
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CIUSSS de l'Estrie-CHUS
Sherbrooke, Quebec, J1H 5N4, Canada
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Cancer Care Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
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Centre Armoricain de Radiotherapie Imagerie medicale et Oncologie
Plérin, 22190, France
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Centre Eugene Marquis
Rennes, 35042, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, 69310, France
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Centre Hospitalier de l Universite de Montreal - CHUM
Montreal, Quebec, H2X 3E4, Canada
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Centre Leon Berard
Lyon, 69008, France
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Centre Oscar Lambret
Lille, 59020, France
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Centre de Lutte Contre le Cancer Francois Baclesse
Caen, 14076, France
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Centro Hemato Oncologico Privado
Toluca, 50080, Mexico
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Centro Oncologico Riojano Integral
La Rioja, F5300COE, Argentina
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Centro de Oncologia e Investigacion Buenos Aires COIBA
Berazategui, Buenos Aires, B1884BBF, Argentina
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Centrum Onkologii Instytut im. Marii Sklodowskiej Curie
Krakow, Lesser Poland Voivodeship, 31-115, Poland
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Centrum Onkologii Instytut im. Marii Sklodowskiej Curie
Gliwice, 44-101, Poland
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Centrum Onkologii. Instytut im. Marii Sklodowskiej-Curie
Warsaw, Masovian Voivodeship, 02-781, Poland
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Chaim Sheba Medical Center
Ramat Gan, 5262000, Israel
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Chang Gung Medical Foundation. Linkou Branch
Taoyuan District, 33305, Taiwan
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Clinica Colsanitas S.A. - Sede Clinica Universitaria Colombia
Bogotá, 111321, Colombia
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Clinica Universitaria Navarra - Madrid
Madrid, 28027, Spain
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Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda
São Paulo, São Paulo, 01317-000, Brazil
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Clinica del Country
Bogota, Cundinamarca, 110221, Colombia
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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EISAI Trial Site 1
Erlangen, Germany
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EISAI Trial Site 1
Hidaka, Saitama, Japan
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EISAI Trial Site 10
Tokyo, Japan
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EISAI Trial Site 11
Sapporo, Hokkaido, Japan
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EISAI Trial Site 12
Tokyo, Japan
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EISAI Trial Site 13
Tokyo, Japan
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EISAI Trial Site 14
Sendai, Miyagi, Japan
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EISAI Trial Site 15
Tōon, Ehime, Japan
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EISAI Trial Site 16
Kagoshima, Japan
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EISAI Trial Site 17
Tsukuba, Ibaraki, Japan
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EISAI Trial Site 18
Kashiwa, Chiba, Japan
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EISAI Trial Site 19
Isehara, Kanagawa, Japan
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EISAI Trial Site 2
Dresden, Germany
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EISAI Trial Site 2
Sunto-gun, Shizuoka, Japan
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EISAI Trial Site 3
Rostock, Germany
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EISAI Trial Site 3
Niigata, Japan
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EISAI Trial Site 4
Berlin, Germany
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EISAI Trial Site 4
Morioka, Iwate, Japan
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EISAI Trial Site 5
Tübingen, Germany
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EISAI Trial Site 5
Kurume, Fukoka, Japan
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EISAI Trial Site 6
Hamburg, Germany
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EISAI Trial Site 6
Tokyo, Japan
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EISAI Trial Site 7
Matsuyama, Ehime, Japan
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EISAI Trial Site 8
Akashi, Hyōgo, Japan
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EISAI Trial Site 9
Nagoya, Aichi-ken, Japan
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Edith Wolfson Medical Center
Holon, 5822012, Israel
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Ege Universitesi Tip Fakultesi
Izmir, 35040, Turkey (Türkiye)
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FSBI National Medical Oncology Research Center n.a. N.N. Blokhina
Moscow, 115478, Russia
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FSBI-FRCC of Special Types Med. Care & Technologies FMBA of Russia
Moscow, 115682, Russia
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Faculdade de Medicina da Universidade Federal de Minas Gerais
Belo Horizonte, 30130-100, Brazil
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Faicic S de RL de CV
Veracruz, 91900, Mexico
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Florence Nightingale Gayrettepe Hastanesi
Istanbul, 34349, Turkey (Türkiye)
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Florida Hospital Cancer Institute
Orlando, Florida, 32804, United States
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
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Fundacao Dr Amaral Carvalho
Jaú, São Paulo, 17210-080, Brazil
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Fundacion Colombiana de Cancerologia Clinica Vida
Medellín, 50032, Colombia
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Fundacion Valle del Lili
Cali, Valle del Cauca Department, 760032, Colombia
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Georgia Cancer Center at Augusta University
Augusta, Georgia, 30912, United States
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Greater Baltimore Medical Center
Baltimore, Maryland, 21204, United States
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Groupe Hospitalier Broca Cochin Hotel Dieu
Paris, 75014, France
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Grupo Medico Camino SC
Mexico City, 3310, Mexico
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Guy s & St Thomas NHS Foundation Trust
London, SE1 9RT, United Kingdom
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Hacettepe University Medical Faculty
Ankara, 06000, Turkey (Türkiye)
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Hadassah Medical Center. Ein Kerem
Jerusalem, 9112001, Israel
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Holy Name Medical Center
Teaneck, New Jersey, 07666, United States
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Hopital Diaconesses Croix Saint Simon
Paris, 75020, France
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Hopital prive du Confluent
Nantes, 44277, France
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Hospital Aleman
Buenos Aires, C1118AAT, Argentina
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Hospital Araujo Jorge
Goiânia, Goiás, 74175-120, Brazil
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Hospital Clinico San Carlos
Madrid, 28040, Spain
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Hospital General Universitari Vall d Hebron
Barcelona, 8035, Spain
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Hospital Privado de la Comunidad
Mar del Plata, Buenos Aires, B7602CBM, Argentina
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Hospital Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Gregorio Maranon
Madrid, 28007, Spain
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Hospital Universitario y Politecnico La Fe de Valencia
Valencia, 46026, Spain
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Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Imperial College Healthcare NHS Trust
London, W12 0HS, United Kingdom
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Institut Bergonie
Bordeaux, 33076, France
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Institut Gustave Roussy
Villejuif, 94800, France
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Institut Regional du Cancer de Montpellier - ICM
Montpellier, 34298, France
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Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, 8908, Spain
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Instituto Medico Especializado Alexander Fleming
Buenos Aires, C1426ANZ, Argentina
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Instituto Nacional do Cancer II
Rio de Janeiro, Rio de Janeiro, 20220-410, Brazil
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Instituto de Investigaciones Metabolicas
Buenos Aires, C1012AAR, Argentina
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Instituto de Oncologia Angel H. Roffo
Buenos Aires, C1417DTB, Argentina
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Instituto do Cancer de Sao Paulo - ICESP
São Paulo, São Paulo, 01246-000, Brazil
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Instytut Centrum Zdrowia Matki Polki
Lodz, 93-338, Poland
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Investigacion Onco Farmaceutica S de RL de CV
La Paz, Estado de Baja California, 23040, Mexico
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Istituto Europeo di Oncologia
Milan, 20141, Italy
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Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, 80131, Italy
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, 47014, Italy
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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John Theurer Cancer Center at Hackensack University Med Ctr
Hackensack, New Jersey, 07601, United States
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Kaohsiung Chang Gung Memorial Hospital of the C.G.M.F.
Kaohsiung City, 833, Taiwan
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Kaohsiung Veterans General Hospital
Kaohsiung City, 813, Taiwan
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Leningrad Regional Oncology Center
Saint Petersburg, 191014, Russia
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London Health Sciences Centre
London, Ontario, N6A 5W9, Canada
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Maryland Oncology Hematology, P.A.
Wheaton, Maryland, 20902, United States
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Mater Misericordiae University Hospital
Dublin, D07 R2WY, Ireland
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Memorial Sloan Kettering Cancer Center
New York, New York, 10022, United States
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Mordovia Republican Oncological Dispensary
Saransk, 430032, Russia
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National Cancer Center
Goyang-si, Gyeonggi-do, 10408, South Korea
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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North Shore University Health System
Evanston, Illinois, 60201, United States
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Oncomedica S.A.
Montería, 230002, Colombia
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Ospedale San Raffaele
Milan, 20132, Italy
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Ottawa General Hospital
Ottawa, Ontario, K1H 8L6, Canada
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Policlinico Universitario Agostino Gemelli
Roma, 168, Italy
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Pomorski Uniwersytet Medyczny w Szczecinie
Szczecin, 70-111, Poland
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Rabin Medical Center
Petah Tikva, 4941492, Israel
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Rambam Medical Center
Haifa, 3525408, Israel
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Republican Clinical Oncology Dispensary of Republic of Bashkortostan
Ufa, 450054, Russia
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Republican Clinical Oncology Dispensary of Tatarstan MoH
Kazan', 420029, Russia
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Rodrigo Botero SAS
Medellín, 50015, Colombia
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Royal Brisbane and Women s Hospital
Herston, Queensland, 4029, Australia
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Royal North Shore Hospital
Sydney, New South Wales, 2065, Australia
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Royal Sussex County Hospital
Brighton, BN2 5BE, United Kingdom
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SPb SBHI City Clinical Oncological Dispensary
Saint Petersburg, 198255, Russia
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Samsung Medical Center
Seoul, 6351, South Korea
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Sanford Gynecology Oncology
Sioux Falls, South Dakota, 57104, United States
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Seoul National University Hospital
Seoul, 3080, South Korea
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Smilow Cancer Hospital at Yale New Haven
New Haven, Connecticut, 06510, United States
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Soroka Medical Center
Beersheba, 84101, Israel
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St John of God
Subiaco, Western Australia, 6008, Australia
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Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Sunnybrook Health Science Centre
Toronto, Ontario, M4N 3M5, Canada
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Szpital Kliniczny im Ks Anny Mazowieckiej
Warsaw, 00-315, Poland
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Szpital Morski im. PCK Szpitale Wojewodzkie w Gdyni Sp. z o.o.
Gdynia, 81-159, Poland
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Taichung Veterans General Hospital
Taichung, 40705, Taiwan
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Taipei Veterans General Hospital
Taipei, Beitou, 11217, Taiwan
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Texas Oncology-San Antonio Medical Center
San Antonio, Texas, 78240, United States
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Texas Oncology-South Austin
Austin, Texas, 78745, United States
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The Royal Marsden Foundation Trust
London, SM2 5PT, United Kingdom
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The Royal Marsden NHS Foundation Trust
London, SW3 6JJ, United Kingdom
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2, Canada
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Tomsk National Research Medical Center of Russian Academy of Sciences
Tomsk, 624028, Russia
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UT West Cancer Center
Germantown, Tennessee, 38138, United States
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Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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University College Hospital
London, WC1E 6AG, United Kingdom
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University Hospital Southampton NHS Foundation Trust
Southampton, SO16 6YD, United Kingdom
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University Medical Center New Orleans
New Orleans, Louisiana, 70112, United States
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University of California Los Angeles
Santa Monica, California, 90095, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Miami Health System
Miami, Florida, 33136, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75390-9032, United States
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Utah Cancer Specialists
Salt Lake City, Utah, 84106, United States
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Willamette Valley Cancer Institute and Research Center
Eugene, Oregon, 97401, United States
Conditions
Explore the condition pages connected to this study.