Could a new combo boost remission in tough leukemia?

NCT ID NCT04802161

First seen Dec 29, 2025 · Last updated Apr 25, 2026 · Updated 18 times

Summary

This study tests whether adding the drug pomalidomide to standard chemotherapy can improve outcomes for people newly diagnosed with a specific type of acute myeloid leukemia (AML) linked to prior blood disorders. About 50 adults will be randomly assigned to receive either the standard chemo alone or the chemo plus pomalidomide. The main goal is to see if the combination leads to more complete remissions.

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Contacts and locations

Locations

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • NYP/Weill Cornell Medical Center

    New York, New York, 10065, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Cincinnati Cancer Center-West Chester

    West Chester, Ohio, 45069, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas, 66205, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

Conditions

Explore the condition pages connected to this study.