PET-Guided radiation shows promise in lung cancer trial

NCT ID NCT01507428

Completed Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Apr 23, 2026 · Last updated Apr 25, 2026 · Updated 1 time

Summary

This study tested whether using PET/CT scans during treatment to adjust radiation doses can better target tumors and spare healthy tissue in people with stage III non-small cell lung cancer. 138 participants received either standard radiation or a personalized, adaptive approach. The goal was to see if this method improves local tumor control without increasing side effects.

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Contacts and locations

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Locations

Augusta University Medical Center

Augusta, Georgia, 30912, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131, United States
Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
McGill University Department of Oncology

Montreal, Quebec, H2W 1S6, Canada
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Sleepy Hollow

Sleepy Hollow, New York, 10591, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

STAGE III LUNG NON-SMALL CELL CANCER AJCC V7 STAGE IIIA LUNG NON-SMALL CELL CANCER AJCC V7 STAGE IIIB LUNG NON-SMALL CELL CANCER AJCC V7