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Could a smarter drug replace harsh chemo for HER2+ breast cancer?

NCT ID NCT05704829

Ongoing Disease control Sponsor: West German Study Group Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 24 times

Summary

This study tests whether a newer, targeted drug (T-DXd) works better than the usual chemotherapy cocktail for women with early-stage HER2-positive breast cancer. About 402 participants will receive either T-DXd or standard chemo before surgery. The goal is to see if T-DXd leads to higher rates of tumor disappearance (pCR) and better long-term outcomes, while reserving chemo only for those who need it.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AGAPLESION Markus Krankenhaus Gynäkologie

    Frankfurt am Main, Hesse, 60431, Germany

  • Breast Center of the University of Munich (LMU) Universitätsfrauenklinik

    Munich, Bavaria, 80336, Germany

  • Brustzentrum Niederrhein, Johanniter Bethesda Krankenhaus

    Mönchengladbach, North Rhine-Westphalia, 41061, Germany

  • Brustzentrum am Krankenhaus Jerusalem

    Hamburg, 20357, Germany

  • CaritasKlinikum Saarbrücken St. Theresia

    Saarbrücken, Saarland, 66113, Germany

  • Charite Campus Mitte

    Berlin, 10117, Germany

  • Ev. Waldkrankenhaus Spandau

    Berlin, 14589, Germany

  • Frauenklinik / Brustzentrum am Klinikum Obergölzsch Rodewisch

    Rodewisch, Saxony, 08228, Germany

  • Frauenklinik St. Louise-St. Vincenz-KH GmbH

    Paderborn, North Rhine-Westphalia, 33098, Germany

  • Helios-Klinik Wuppertal

    Wuppertal, North Rhine-Westphalia, 42283, Germany

  • Hämotologisch onkologische Praxis Heinrich Bangerter Augsburg GbR

    Augsburg, Bavaria, 86150, Germany

  • Kliniken Essen-Mitte, Klinik für Senologie/Interdisziplinäres Brustzentrum

    Essen, North Rhine-Westphalia, 45136, Germany

  • Kliniken der Stadt Köln GmbH / Brustzentrum Holweide

    Cologne, North Rhine-Westphalia, 51067, Germany

  • Kliniken für Frauenheilkunde / Universitätsklinikum Düsseldorf

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Klinikum Bremerhaven Reinkenheide

    Bremerhaven, Free Hanseatic City of Bremen, 27574, Germany

  • Klinikum Frankfurt Höchst GmbH

    Frankfurt am Main, Hesse, 65929, Germany

  • Klinikum Kassel

    Kassel, Hesse, 34125, Germany

  • Klinikum Mittelbaden, Brustzentrum

    Baden-Baden, Baden-Wurttemberg, 76532, Germany

  • Klinikum Mutterhaus

    Trier, Rhineland-Palatinate, 54290, Germany

  • Luisenkrankenhaus GmbH

    Düsseldorf, North Rhine-Westphalia, 40235, Germany

  • MKS St. Paulus GmbH

    Schwerte, North Rhine-Westphalia, 58239, Germany

  • MVZ Klinik Dr. Hancken GmbH

    Stade, Lower Saxony, 21680, Germany

  • MVZ Media Vita am St. Franziskus Hospital

    Münster, North Rhine-Westphalia, 48145, Germany

  • Niels-Stensen-Kliniken Franziskus-Hospital

    Georgsmarienhütte, Lower Saxony, 49124, Germany

  • Onkodok Gütersloh

    Gütersloh, North Rhine-Westphalia, 33332, Germany

  • Onkologische Schwerpunktpraxis Bielefeld

    Bielefeld, North Rhine-Westphalia, 33604, Germany

  • Praxis für Interdisziplinäre Onkologie und Hämatologie (PIO)

    Freiburg im Breisgau, Baden-Wurttemberg, 79110, Germany

  • Praxisnetzwerk Hämatologie und intern. Onkologie

    Troisdorf, North Rhine-Westphalia, 53840, Germany

  • Rotkreuz Klinikum München

    Munich, Bavaria, 80634, Germany

  • Sankt-Antonius-Hospital

    Eschweiler, North Rhine-Westphalia, 52249, Germany

  • St. Barbara Klinik

    Hamm, North Rhine-Westphalia, 59073, Germany

  • St. Elisabeth Krankenhaus GmbH

    Cologne, North Rhine-Westphalia, 50935, Germany

  • Studien GbR Braunschweig

    Braunschweig, Lower Saxony, 38100, Germany

  • UK Schleswig Holstein

    Lübeck, Schleswig-Holsteins, 23538, Germany

  • Uniklinik RWTH Aachen

    Aachen, North Rhine-Westphalia, 52074, Germany

  • Universittsklinikum am Klinikum Südstadt

    Rostock, ecklenburg-Vorpommerns, 18059, Germany

  • Universitätsklinikum Augsburg / Klinik für Frauenheilkunde und Geburtshilfe

    Augsburg, Bavaria, 86156, Germany

  • Universitätsklinikum Essen, Brustzentrum

    Essen, North Rhine-Westphalia, 45147, Germany

  • Universitätsklinikum Hamburg-Eppendorf / Klinik und Poliklinik für Gynäkologie

    Hamburg, 20246, Germany

  • Universitätsklinikum Leipzig

    Leipzig, Saxony, 04103, Germany

  • Universitätsklinikum Tübingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitätsklinikum Ulm

    Ulm, Baden-Wurttemberg, 89075, Germany

  • Ärztehaus am Bahnhofsplatz

    Hildesheim, Lower Saxony, 31134, Germany

Conditions

Explore the condition pages connected to this study.

HER2-POSITIVE EARLY BREAST CANCER