New combo attack on lung cancer brain tumors shows promise in early trial

NCT ID NCT06248606

Recruiting now Disease control Sponsor: Ryan Gentzler, MD Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 26 times

Summary

This study tests whether combining a targeted drug (adagrasib) with precise radiation (stereotactic radiosurgery) can better control brain metastases in people with a specific type of lung cancer (KRAS G12C-mutated NSCLC). About 30 adults with untreated brain tumors will receive both treatments. The goal is to see if the cancer in the brain shrinks or stays stable for at least 3 months.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

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University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22908, United States

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Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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KRAS G12C KRAS G12C NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER NSCLC