New smart alerts help surgeons prevent kidney injury during operations
NCT ID NCT05957406
First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times
Summary
This study tested a smart alert system that warns doctors when a patient's blood pressure might drop dangerously during surgery. The goal was to help doctors act quickly to prevent kidney injury. The trial included 296 adults having major noncardiac surgery. The system uses software and a special sensor to track blood pressure trends in real time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Acumen HPI Smart Alerts and Smart Trends Software (a device that gives doctors early warnings about low blood pressure during surgery)
- What this could lead to
- If it works, this could help prevent kidney damage after major surgery by catching dangerous blood pressure drops early.
- What could go wrong
- This was a small, early feasibility study with historical controls, not a randomized trial. The results may not apply to all patients or surgeries.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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296 people
The number who actually took part.
- Started
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Jul 2023
- Finished
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Oct 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Signed informed consent * Age ≥ 18 years * ASA Physical Status ≥ 2 * Elective noncardiac surgery with expected surgery duration ≥ 3 hours and expected post-operative length of stay of ≥ 3 days * Planned monitoring with an arterial catheter; Cohort 2: without planned arterial catheter insertion * General anesthesia with tracheal intubation and positive pressure ventilation Exclusion Criteria: * Inability to comply with the study intra-operative hemodynamic management algorithm such as surgeon request for relative hypotension or fluid restriction or avoidance of vasopressors * Planned vasopressor or inotrope infusion during surgery * Contraindication to intra-arterial blood pressure monitoring * Has previously participated in the SMART TRENDS study * Serum creatine \> 2.0 mg/dL (\> 175 μmol/L) or CKD stage \> 3A * Scheduled for intracranial or cardiac surgery * Patient who is known to be pregnant * Patients on mechanical circulatory support * Emergency surgery * Planned beach-chair positioning Additional Exclusion Criteria for Cohort 2 only: * Extreme contraction of the smooth muscle in the arteries and arterioles of the lower arm and hand, such as may be present in patients with Raynaud's disease * Finger or hand deformity that prevents proper placement of finger cuff by visual inspection * Inability to place Acumen IQ finger cuffs due to subject anatomy, condition, or obstructive paraphernalia (such as false nails)
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Duke University
Durham, North Carolina, 27705, United States
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Henry Ford Health System
Detroit, Michigan, 48202, United States
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Oregon Health & Science University
Portland, Oregon, 997239, United States
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Prisma Health
Greenville, South Carolina, 29615, United States
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UC Davis Medical Center
Sacramento, California, 95817, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Washington
Seattle, Washington, 98195, United States
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Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157, United States