Personalized cancer drug trial seeks to control advanced uterine cancer

NCT ID NCT05548296

Recruiting now Disease control Sponsor: Acrivon Therapeutics Source: ClinicalTrials.gov ↗

Summary

This study is testing whether the drug ACR-368 can help control advanced endometrial cancer that has progressed after previous treatments. The trial will enroll 353 participants and uses a personalized approach: some patients receive ACR-368 alone while others receive it with a low-dose sensitizing drug, depending on their tumor test results. The main goal is to see how many patients' tumors shrink and to monitor safety.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Locations

Alaska Women's Cancer Center
COMPLETED

Anchorage, Alaska, 99508, United States
American Oncology Partners of Maryland PA
COMPLETED

Bethesda, Maryland, 20817, United States
Arizona Oncology Associate, PC- HOPE
RECRUITING

Tucson, Arizona, 85711, United States

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Ascension St. Vicent Hospital, Inc.
RECRUITING

Indianapolis, Indiana, 46260, United States

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CRO Aviano
NOT_YET_RECRUITING

Aviano, Italy

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Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

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Centre François Baclesse
NOT_YET_RECRUITING

Caen, France

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Centre Léon Bérard
NOT_YET_RECRUITING

Lyon, France

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City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States

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Cleveland Clinic Foundation
COMPLETED

Cleveland, Ohio, 44195, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States

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Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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FirstHealth of the Carolinas
RECRUITING

Pinehurst, North Carolina, 28374, United States

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Florida Gynecologic Oncology/Regional Cancer Center
COMPLETED

Fort Myers, Florida, 33905, United States
Fondazione Pascale Istituto Tumori
NOT_YET_RECRUITING

Naples, Italy

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Fox Chase Cancer Center
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center
COMPLETED

Seattle, Washington, 98109, United States
Froedtert and Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Fundacion Instituto Valenciano de Oncologia (IVO)
NOT_YET_RECRUITING

Valencia, Spain

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Gabrail Cancer Center
COMPLETED

Canton, Ohio, 44718, United States
HCA Midwest
RECRUITING

Kansas City, Missouri, 64132, United States

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Hoag Cancer Center
RECRUITING

Newport Beach, California, 92663, United States

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Holy Cross Hospital
COMPLETED

Silver Spring, Maryland, 20910, United States
HonorHealth
RECRUITING

Phoenix, Arizona, 85016, United States

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Hospital Clínic de Barcelona
NOT_YET_RECRUITING

Barcelona, Spain

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Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, Spain

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Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, Spain

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Hospital Universitario Ramón y Cajal
NOT_YET_RECRUITING

Madrid, Spain

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Humanitas University
NOT_YET_RECRUITING

Pieve Emanuele, Italy

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Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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Insitute de Cancérologie de l'Ouest
NOT_YET_RECRUITING

Saint-Herblain, France

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Institut Català of Oncology (ICO)
NOT_YET_RECRUITING

Barcelona, Spain

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Institute Gustave Roussy
NOT_YET_RECRUITING

Villejuif, France

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Istituto Clinico Cannizzaro Catania
NOT_YET_RECRUITING

Catania, Italy

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Istituto Europeo di Oncologia
NOT_YET_RECRUITING

Milan, Italy

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John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States

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KEM | Evang. Kliniken Essen-Mitte
NOT_YET_RECRUITING

Essen, Germany

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Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

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LSU Health Sciences
RECRUITING

New Orleans, Louisiana, 70112, United States

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Laura & Isaac Perlmutter Cancer Center
RECRUITING

New York, New York, 10016, United States

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Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

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Mount Sinai Comprehensive Cancer Center
RECRUITING

Miami Beach, Florida, 33140, United States

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Mount Sinai Health System
RECRUITING

New York, New York, 10128, United States

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National Institutes of Health, Clinical Center
ACTIVE_NOT_RECRUITING

Bethesda, Maryland, 20892, United States
New York Presbyterian Hospital-Columbia University Medical Center
COMPLETED

New York, New York, 10032, United States
Northeast Georgia Medical Center
COMPLETED

Gainesville, Georgia, 30501, United States
Northwest Cancer Specialists, P.C.
COMPLETED

Vancouver, Washington, 98684, United States
Northwestern Medicine
RECRUITING

Chicago, Illinois, 60611, United States

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Ohio State University
RECRUITING

Hilliard, Ohio, 43026, United States

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Oncology Associates of Oregon
COMPLETED

Eugene, Oregon, 97401, United States
Oregon Health & Sciences University
COMPLETED

Portland, Oregon, 97239, United States
Ospedale Mauriziano Torino
NOT_YET_RECRUITING

Turin, Italy

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Policlinico Gemelli
NOT_YET_RECRUITING

Roma, Italy

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Providence Sacred Heart Medical Center and Children's Hospital
RECRUITING

Spokane, Washington, 99204, United States

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Rutgers Cancer Institute of NJ
RECRUITING

New Brunswick, New Jersey, 08903, United States

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Sanford Health
RECRUITING

Sioux Falls, South Dakota, 57104, United States

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Stanford Cancer Center
RECRUITING

Palo Alto, California, 94304, United States

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Stephenson Cancer Center at OU Health
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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Summit Cancer Center
COMPLETED

Spokane, Washington, 99208, United States
Swedish Cancer Center
RECRUITING

Seattle, Washington, 98104, United States

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Texas Oncology
COMPLETED

Fort Worth, Texas, 76104, United States
Texas Oncology-Dallas Presbyterian Hospital
COMPLETED

Dallas, Texas, 75231, United States
Trials365, LLC
RECRUITING

Shreveport, Louisiana, 71103, United States

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UC Irvine Health
ACTIVE_NOT_RECRUITING

Orange, California, 92868, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States

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USC/Norris Comprehensive Cancer Center
COMPLETED

Los Angeles, California, 90033, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States

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University of California Los Angeles (UCLA)
RECRUITING

Santa Monica, California, 90404, United States

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University of California, Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States

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University of Chicago Medicine
RECRUITING

Chicago, Illinois, 60637, United States

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University of Cincinnati Cancer Center
RECRUITING

Cincinnati, Ohio, 45267, United States

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University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States

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University of Illinois Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States

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University of Iowa
RECRUITING

Iowa City, Iowa, 52252, United States

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University of Massachusetts Chan Medical School
COMPLETED

Worcester, Massachusetts, 01605, United States
University of North Carolina at Chapel Hill
COMPLETED

Chapel Hill, North Carolina, 27599, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States

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University of South Alabama Mitchell Cancer Institute
COMPLETED

Mobile, Alabama, 36604, United States
University of Texas Southwestern Medical Center
COMPLETED

Dallas, Texas, 75390, United States
University of Texas, MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States

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Universitätsklinikum Münster, Klinik für Frauenheilkunde und Geburtshilfe
NOT_YET_RECRUITING

Münster, Germany

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Universitätsklinikum Ulm, Frauenheilunde und Geburtshilfe
NOT_YET_RECRUITING

Ulm, Germany

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Vall d'Hebron Institute of Oncology (VHIO)
NOT_YET_RECRUITING

Barcelona, Spain

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Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

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Women & Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States

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Yale Cancer Center
COMPLETED

New Haven, Connecticut, 06520, United States

Conditions

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ENDOMETRIAL ADENOCARCINOMA