New combo therapy aims to control stubborn leukemia
NCT ID NCT04169737
First seen Nov 01, 2025 · Last updated May 04, 2026 · Updated 25 times
Summary
This study tests whether a combination of two targeted drugs (acalabrutinib and venetoclax) with or without an early dose of a third drug (obinutuzumab) can better control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that is high-risk, has returned, or stopped responding to treatment. About 168 adults will receive the drug combination to see if it can reduce cancer to undetectable levels in the bone marrow. The goal is disease control, not a cure, as ongoing management may still be needed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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