Gene therapy breakthrough for rare kidney disease enters human trials
NCT ID NCT06839235
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new gene therapy called ABO-101 for people with Primary Hyperoxaluria Type 1 (PH1), a rare genetic disorder that causes kidney stones and kidney damage. The trial will first test single doses in adults to find the safest dose, then test that dose in children. Researchers will monitor side effects and measure changes in urine oxalate levels to see if the treatment works.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Heidi Chaker
RECRUITINGSfax, Tunisia
Contact Phone: •••-•••-••••
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Hospices Civils de Lyon- Hôpital Femmes Mères Enfants
NOT_YET_RECRUITINGLyon, France
Contact Phone: •••-•••-••••
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Kindernierenzentrum Bonn
NOT_YET_RECRUITINGBonn, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-••••
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Nucleus Network
WITHDRAWNSaint Paul, Minnesota, 55114, United States
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Queen Elizabeth Hospital Birmingham
RECRUITINGBirmingham, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Free Hospital
RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••