New combo shrinks prostate tumors before radiation in early trial

NCT ID NCT02160353

First seen Apr 14, 2026 · Last updated May 15, 2026 · Updated 4 times

Summary

This study tested whether giving a combination of abiraterone acetate, prednisolone, and a hormone-blocking drug for about 4 months before radiation could shrink tumors and lower PSA in 45 men with high-risk localized prostate cancer. The goal was to improve treatment response before starting radiation. Results showed reductions in tumor size, PSA, and prostate volume, but long-term disease control still requires ongoing management.

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Contacts and locations

Locations

  • Cork University Hospital

    Cork, Ireland

  • St Luke's Hospital

    Dublin, 6, Ireland

  • University Hospital Galway

    Galway, Ireland

Conditions

Explore the condition pages connected to this study.