Cervical lesion drug trial halted early

NCT ID NCT05502367

Terminated Disease control Sponsor: Antiva Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a vaginal insert called ABI-2280 in women with cervical precancerous lesions (CIN). The goal was to see if it was safe and could help clear the abnormal cells. The trial was stopped early, so we don't have full results. It involved 44 women aged 25-55 who used the insert themselves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABI-2280 vaginal insert
What this could lead to: If it had worked, this could point toward a non-surgical treatment for cervical precancerous lesions.
What could go wrong: The trial was terminated early, so we don't have clear results. It was also a small, early-phase study, so success was never guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical intraepithelial neoplasia cervical squamous intraepithelial neoplasia dysplasia of cervix

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL INTRAEPITHELIAL NEOPLASIA

Contacts and locations

Locations

Botho ke Bontle Health Services

Waltloo, Gauteng, 0184, South Africa
CerviCusco

Cusco, Peru
East Sydney Doctors

Darlinghurst, New South Wales, 2010, Australia
Farmovs

Bloemfontein, Free State, 9301, South Africa
Ginobs S.A.

Lima, Peru
Gole Biomedical Research Centre

Ga-Mothapo, Limpopo, South Africa
Nafasi Integrated Solutions

Sunnyside, Gauteng, 0002, South Africa

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