Blood and gel combo may strengthen dental implant bone growth

NCT ID NCT07792720

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Sep 03, 2026 · Updated 2 times

Summary

This trial tests whether applying a gel made from a patient's own blood, called advanced platelet-rich fibrin (A-PRF), along with hyaluronic acid, can improve bone formation around dental implants. Adults aged 18 to 65 who need a delayed implant in the lower jaw will either receive the standard implant procedure or the implant plus the A-PRF and hyaluronic acid combination. Researchers will measure bone density and volume using 3D imaging, as well as implant stability, pain, and implant survival over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Advanced platelet-rich fibrin (A-PRF) combined with hyaluronic acid, applied at the dental implant site
What this could lead to
If it works, this could point toward a way to improve bone healing around dental implants, potentially reducing implant failure and improving long-term outcomes.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply broadly. The added biomaterials could also carry risks like infection or inflammation, and the benefit over standard care is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Adults aged 18-65 years. Patients requiring delayed dental implant placement in a posterior mandibular edentulous site Sufficient residual alveolar bone height and width to permit conventional implant placement without the need for simultaneous guided bone regeneration (GBR), ridge augmentation, or other bone-grafting procedures. Good general health or a medically controlled and stable systemic condition compatible with elective implant surgery and not expected to materially compromise wound or bone healing. Non-smokers with no current use of tobacco products. Acceptable oral hygiene and a periodontal condition compatible with implant surgery following any required professional treatment and reassessment. Ability and willingness to undergo the required clinical and radiographic assessments, including CBCT examinations at baseline and at the 6-month follow-up. Ability and willingness to attend the scheduled follow-up visits and comply with the study procedures. Provision of written informed consent before study participation. Exclusion Criteria: \- Any uncontrolled systemic disease or medical condition that conensions for conventional implant placement without augmentation. Requirement for immediate implant placement, simultaneous guided bone regeneration, ridge augmentation, or any other adjunctive bone-grafting procedure. Inability or unwillingness to complete the required 6-month clinical and radiographic follow-up.traindicates elective implant surgery or may substantially impair wound or bone healing, including uncontrolled diabetes mellitus. Immunocompromised status or current systemic immunosuppressive therapy. Current or previous use of oral or parenteral bisphosphonates or other antiresorptive medications associated with a risk of medication-related osteonecrosis of the jaw. Pregnancy at the time of screening or enrollment. Unresolved active periodontal disease or active local infection involving the intended implant site, including suppuration. Inadequate oral hygiene that persists after professional oral-hygiene instruction, necessary periodontal treatment, and reassessment. Insufficient residual alveolar bone dim

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As listed by the trial registrant

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How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Beauty Smile Dental Center

    RECRUITING

    Sanaa, Sana'a, Yemen

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