One-Shot gene therapy could free patients from monthly eye injections

NCT ID NCT06864988

Ongoing Disease control Sponsor: 4D Molecular Therapeutics Source: ClinicalTrials.gov ↗

Summary

This late-stage trial is testing whether a single injection of an experimental gene therapy called 4D-150 can control vision loss from wet age-related macular degeneration (AMD). It aims to see if this one-time treatment can reduce or eliminate the need for the frequent eye injections patients currently require. The study will compare 4D-150 against the standard treatment, aflibercept, in about 480 adults with this form of advanced AMD.

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Contacts and locations

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Locations

Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
Austin Clinical Research

Austin, Texas, 78750, United States
Austin Research Center for Retina

Austin, Texas, 78705, United States
Austin Retina Associates

Austin, Texas, 78705, United States
Barnet Dulaney Perkins Eye Center

Phoenix, Arizona, 85016, United States
Bay Area Retina Associates

Walnut Creek, California, 94598, United States
Black Hills Regional Eye Institute

Rapid City, South Dakota, 57701, United States
Calgary Retina Consultants

Calgary, Alberta, T2H 0C8, Canada
California Retina Consultants

Bakersfield, California, 93309, United States
California Retina Consultants - Santa Barbara

Santa Barbara, California, 93103, United States
Charleston Neuroscience Center

Charleston, South Carolina, 29414, United States
Charleston Neuroscience Institute

Ladson, South Carolina, 29456, United States
Cole Eye Institute

Cleveland, Ohio, 44195, United States
Connecticut Eye Consultants

Danbury, Connecticut, 06810, United States
Cumberland Valley Retina Consultants PC

Hagerstown, Maryland, 21740, United States
Deep Blue Retina Clinical Research

Southaven, Mississippi, 38671, United States
Duke Eye Center

Durham, North Carolina, 27705, United States
East Florida Eye Institute

Stuart, Florida, 34994, United States
Envision Ocular, LLC

Bloomfield, New Jersey, 07003, United States
Erie Retina Research

Erie, Pennsylvania, 16507, United States
Eye Associates of New Mexico Vision Research Center

Albuquerque, New Mexico, 87109, United States
Eye Clinic of Wisconsin

Wausau, Wisconsin, 54403, United States
EyeHealth Northwest Peterkort

Portland, Oregon, 97225, United States
Florida Retina Consultants

Lakeland, Florida, 33805, United States
Florida Retina Institute

Orlando, Florida, 32806, United States
Florida Retina Institute - Jacksonville

Jacksonville, Florida, 32216, United States
Georgia Retina PC

Marietta, Georgia, 30060, United States
Haik Humble Eye Center

West Monroe, Louisiana, 71291, United States
Illinois Retina Associates

Oak Park, Illinois, 60304, United States
Jules Stein Eye Institute

Los Angeles, California, 90095, United States
Kaiser Permanente-Riverside Medical Center

Riverside, California, 92505, United States
Krembil Neuroscience Centre

Toronto, Ontario, M5T 2S8, Canada
Loma Linda University Faculty Medical Clinics

Loma Linda, California, 92354, United States
MD Medical Research

Waldorf, Maryland, 20745, United States
Maine Eye Center

Portland, Maine, 04101, United States
Mid Atlantic Retina

Bethlehem, Pennsylvania, 18017, United States
Mid Atlantic Retina Specialists - Hagerstown

Hagerstown, Maryland, 21740, United States
Midwest Eye Institute

Carmel, Indiana, 46290, United States
Mississippi Retina Associates

Madison, Mississippi, 39110, United States
NJ Retina

Edison, New Jersey, 08820, United States
NJ Retina

Teaneck, New Jersey, 07666, United States
New England Retina Consultants

Springfield, Massachusetts, 01107, United States
North Carolina (NC) Retina Associates

Wake Forest, North Carolina, 27587, United States
Northern California Retina Vitreous Associates

Mountain View, California, 94040, United States
Orange County Retina Medical Group

Santa Ana, California, 92705, United States
Palmetto Retina Center

West Columbia, South Carolina, 29169, United States
Piedmont Eye Center

Lynchburg, Virginia, 24502, United States
Piedmont Retina Specialists - Winston Salem Office

Winston-Salem, North Carolina, 27157, United States
RCTX - Westover Hills Retina Center

San Antonio, Texas, 78251, United States
RSC Research, LLC

Denver, Colorado, 80210, United States
Retina & Vitreous of Texas, PLLC

Bellaire, Texas, 77401, United States
Retina Associates - Elmhurst

Elmhurst, Illinois, 60126, United States
Retina Associates of Cleveland

Cleveland, Ohio, 44122, United States
Retina Associates of Cleveland

Cleveland, Ohio, 44130, United States
Retina Associates of Kentucky

Lexington, Kentucky, 40509, United States
Retina Associates of Sarasota

Sarasota, Florida, 34232, United States
Retina Associates of South Texas PA

San Antonio, Texas, 78240, United States
Retina Associates of Southern California

Huntington Beach, California, 92647, United States
Retina Associates of Western New York

Rochester, New York, 14620, United States
Retina Consultants of Hawaii

‘Aiea, Hawaii, 96701, United States
Retina Consultants of Houston

Bellaire, Texas, 77401, United States
Retina Consultants of San Diego

Poway, California, 92064, United States
Retina Consultants of Southern Colorado

Colorado Springs, Colorado, 80909, United States
Retina Consultants of Texas

The Woodlands, Texas, 77384, United States
Retina Consultants of Texas San Antonio

San Antonio, Texas, 78240, United States
Retina Group of Florida

Fort Lauderdale, Florida, 33308, United States
Retina Group of Washington

Chevy Chase, Maryland, 20815, United States
Retina Group of Washington

Fairfax, Virginia, 22031, United States
Retina Institute of Ottawa, Inc.

Ottawa, Ontario, K2B 7E9, Canada
Retina Institute of Virginia

Richmond, Virginia, 23235, United States
Retina Partners of Northwest Arkansas

Springdale, Arkansas, 72764, United States
Retina Research Institute of Texas

Abilene, Texas, 79606, United States
Retina Specialty Institute

Pensacola, Florida, 32503, United States
Retina Surgical Associates

New Westminster, British Columbia, V3L 5H1, Canada
Retina Vitreous Associates Medical Group

Beverly Hills, California, 90211, United States
Retina Vitreous Associates of Florida

St. Petersburg, Florida, 33711, United States
Retina Vitreous Center

Edmond, Oklahoma, 73013, United States
Retina-Vitreous Surgeons of Central New York

Liverpool, New York, 13088, United States
Retinal Consultants Medical Group Inc

Sacramento, California, 95825, United States
Retinal Consultants Medical Group Inc

Sacramento, California, 95840, United States
Retinal Research Institute, LLC

Scottsdale, Arizona, 85254, United States
Sierra Eye Associates

Reno, Nevada, 89502, United States
Southeast Retina Center

Augusta, Georgia, 30909, United States
Southeastern Retina Associates

Knoxville, Tennessee, 37763, United States
Springfield Clinic

Springfield, Illinois, 62703, United States
St. Michaels Hospital

North York, Ontario, M5B 1W8, Canada
Strategic Clinical Research Group, LLC

Willow Park, Texas, 76087, United States
Texas Retina Associates

Arlington, Texas, 76012, United States
Texas Retina Center

Houston, Texas, 77043, United States
The Retina Institute

St Louis, Missouri, 63128, United States
The Retina Partners

Encino, California, 91436, United States
The Scheie Eye Institute

Philadelphia, Pennsylvania, 19104, United States
University Retina and Macula Associates, PC

Lemont, Illinois, 60439, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Colorado, Denver

Aurora, Colorado, 80045, United States
Verum Research, LLC

Eugene, Oregon, 97401, United States
Vitreo Retinal Associates

Gainesville, Florida, 34481, United States
Vitreous Retina Macula Consultants of New York

New York, New York, 10022, United States
Western Carolina Retinal Associate PA

Asheville, North Carolina, 28803, United States
Wilmer Eye Institute John's Hopkins University

Baltimore, Maryland, 21287, United States

Conditions

Explore the condition pages connected to this study.

MACULAR NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION