Memorial Sloan Kettering Cancer Center

This study compares standard radiation (24 Gy) to a very low dose (4 Gy) for people with follicular or marginal zone lymphoma. The goal is to see if the low dose works just as well but causes fewer side effects. About 375 participants will be enrolled, and the study is currently …

This study tests whether adding surgery and targeted radiation to standard treatment can cure HER2-positive breast cancer that has spread to up to 5 spots in the body. About 178 adults with this condition will be randomly assigned to get either usual care alone or usual care plus…

This study tests a personalized approach for people with HER2-positive metastatic breast cancer. Doctors use a series of ctDNA blood tests and imaging scans to decide when to increase or decrease treatments, combined with local therapies and brain-spine protection. The goal is to…

This study tests whether adding cyclophosphamide to elranatamab can improve outcomes for people with multiple myeloma that has returned or stopped responding to prior treatments, especially those with risk factors that make standard therapy less effective. About 26 adults with me…

This early-phase trial tests whether freezing a tumor (cryoablation) can boost the immune system's response to the drug pembrolizumab in people with advanced triple-negative breast cancer. About 30 participants will either receive the combination or pembrolizumab alone. The goal …

This study is testing whether two drugs, avutometinib and defactinib, can shrink or control advanced or recurrent mesonephric gynecologic cancer, a rare type of cancer. About 40 women with this cancer that has not responded to standard treatment will receive the drug combination.…

This study tests a drug called mirdametinib for people with certain brain or spinal cord tumors (like glioma). The goal is to see if the drug can shrink or control the tumors. About 26 adults will take part. The drug targets a specific genetic change (MAPK pathway) found in some …

This study tests two immunotherapy drugs, botensilimab and balstilimab, given before surgery for people with a common type of locally advanced rectal cancer (MMRp/MSS). The goal is to see if this combination can shrink or eliminate tumors safely, possibly reducing the need for mo…

This study tests whether a combination of two drugs (botensilimab and balstilimab) can clear leftover cancer DNA in people with colorectal cancer who still have signs of disease after surgery and chemotherapy. About 284 adults with a specific type of colorectal cancer (MSS) will …

This study tests whether combining two drugs, axitinib and nivolumab, can shrink or control advanced mucosal melanoma, a rare cancer that starts in moist lining tissues. About 20 people with untreated, advanced disease will receive the combination. If the cancer worsens, some may…

This study compares a new drug combination (vemurafenib plus obinutuzumab) to the standard treatment (cladribine plus rituximab) for people with untreated hairy cell leukemia. The goal is to see which approach causes fewer side effects and works better at eliminating cancer cells…

This early-phase study tests the safety of an experimental drug (BMS-986504) combined with standard cancer treatments in 60 people whose advanced solid tumors (mesothelioma, stomach/esophageal cancer, or bladder cancer) lack the MTAP gene. The goal is to find a safe dose and see …

This study tests whether the drug talquetamab can help people with multiple myeloma who have already received a type of immunotherapy called CAR T-cell therapy. The goal is to see if adding talquetamab can keep the cancer from coming back. About 17 adults whose disease is stable …

This study is testing a new approach for people with certain head and neck cancers: using lower doses of radiation and chemotherapy, followed by surgery to remove any remaining cancer in the neck. The goal is to see if this gentler treatment can still control the cancer while red…

This study is for people with advanced breast cancer that is triple-negative or has low estrogen receptors and tests positive for androgen receptors. It compares two experimental treatments—enzalutamide alone or with mifepristone—against standard chemotherapy. The goal is to see …

This study tests whether a drug called IgPro20 can reduce infections in people with multiple myeloma who have low antibody levels due to bispecific antibody treatment. About 100 participants will either receive IgPro20 or standard care, and infection rates will be compared over 6…

This study is for women 45 and older with early-stage breast cancer or DCIS who have had a lumpectomy. It tests whether a very short course of targeted radiation (over a few days instead of weeks) is safe and works as well as standard treatment. The main goal is to see if this ap…

This study tests if pembrolizumab, a drug that helps the immune system attack cancer, can shrink tumors in people with ultra-rare sarcomas. About 32 adults with specific rare sarcoma types will receive the drug. The goal is to see if it works and has mild side effects.

This study tests a drug called pasireotide in 10 adults with prolactinomas (pituitary tumors) who cannot use standard dopamine agonist therapy due to side effects, contraindications, or resistance. The goal is to see if pasireotide can safely lower prolactin levels to normal and …

This study tests an improved method for cord blood transplants in adults with hard-to-treat blood cancers like leukemia and lymphoma. The approach uses a standard set of steps—including chemotherapy, radiation, and careful follow-up—to help the body accept the new stem cells. Res…

This study tests a procedure called gastric preconditioning, done before esophageal cancer surgery, to see if it can prevent a serious complication called an anastomotic leak. The procedure uses a tiny tube to block some blood vessels in the stomach, which may help it heal better…

This study tests a drug called sacituzumab govitecan in 33 people with mesothelioma that has returned or spread after prior treatment. The goal is to see if the drug can shrink tumors and control the disease. Participants receive the drug until it stops working, side effects beco…

This study tests a drug called enasidenib in people with a rare type of T-cell lymphoma (AITL) that has a specific genetic change (IDH2 mutation). The goal is to see if the drug is safe and effective when given alone or with another drug, rituximab. About 25 adults whose cancer h…

This study tests whether giving emapalumab early can help children with aplastic anemia recover their blood cell counts within six weeks. About 35 children with newly diagnosed severe aplastic anemia will receive the drug before standard treatments. The goal is to see if this app…

This study tests whether adding the drug pembrolizumab to standard chemotherapy (GVD) can help people with Hodgkin lymphoma that has returned or not responded to initial treatment. About 257 participants will receive the combination, and those who respond well may go on to a stem…

This study tests whether adding two immunotherapy drugs (cemiplimab and cetuximab) to standard chemotherapy before surgery is safe and effective for people with advanced head and neck cancer. The goal is to see if this combination can help patients avoid needing radiation therapy…

This study tests whether adding siltuximab (a drug that blocks a protein called IL-6) to a personalized dose of melphalan (chemotherapy) works better than the standard melphalan dose for people over 60 with multiple myeloma who are getting a stem cell transplant. About 215 partic…

This study is for people with HPV-related throat cancer who have had or will have surgery to remove the tumor. Researchers will use a blood test to look for tiny bits of cancer DNA (ctDNA) to see if the cancer is likely to come back. The goal is to find out if some patients can s…

This early-stage study tests the safety of combining two drugs, ruxolitinib and duvelisib, in people with T- or NK-cell lymphoma that has come back or not responded to prior treatments. The goal is to find the best dose and see if the combination can control the disease. About 70…

This study tests a drug called selinexor in children and young adults whose Wilms tumor, rhabdoid tumor, or other solid tumors have come back or not responded to treatment. The goal is to see if the drug can shrink tumors. About 45 participants will take selinexor pills, and doct…

This study tests the safety of a new drug called ivonescimab when given with standard chemotherapy and precise radiation (SRS) to people with non-small cell lung cancer that has spread to the brain. About 53 adults will join to find the best dose with the fewest side effects, and…

This early-phase study tests whether giving deferoxamine directly into the spinal fluid is safe for people with leptomeningeal metastases (cancer spread to the brain and spinal cord lining). About 35 adults with solid tumor cancers will receive different doses to find the highest…

This study tests a combination of a bivalent vaccine, a sugar called beta-glucan, and a protein (GM-CSF) to help the immune system fight high-risk neuroblastoma that is in complete remission. About 286 participants will receive the vaccine and beta-glucan, with some also getting …

This early-phase trial tests a treatment made from your own immune cells (called tumor-infiltrating lymphocytes, or TILs) for advanced uveal melanoma, undifferentiated pleomorphic sarcoma, or dedifferentiated liposarcoma. About 30 participants will have their tumor removed, have …

This study tests a time-limited combination of three drugs (pirtobrutinib, venetoclax, and rituximab) in 40 adults newly diagnosed with Waldenström's macroglobulinemia, a rare blood cancer. The goal is to see if this treatment can achieve a very good partial response or better. P…

This study tests the drug cabozantinib in people with advanced non-small cell lung cancer that has certain gene changes (RET, ROS1, NTRK fusions, or increased MET or AXL activity). The goal is to see if the drug can shrink tumors and stop them from growing. About 86 participants …

This study is for people who had surgery for oral tongue cancer. It tests whether giving radiation only to the neck lymph nodes (not the mouth) can lower painful mouth sores and other side effects. Researchers will track cancer return rates and quality of life. About 24 adults wi…

This study tests whether adding a liver-directed chemotherapy (HAI FUDR/Dexamethasone) to standard chemo (GemOx) can delay cancer growth in people with bile duct cancer that can't be surgically removed. About 164 adults with cancer confined to the liver will be randomly assigned …

This study tests whether a cord blood transplant (using stem cells from donated umbilical cord blood) can help children and young adults up to age 26 with blood cancers like leukemia or lymphoma. Participants receive the transplant as their first or second treatment. The main goa…

This early-phase study tests a radioactive drug (131-I apamistamab) given before CAR T-cell therapy for people with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia or diffuse large B-cell lymphoma. The goal is to find a safe dose and see if the combination is tolera…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. Participants continue their usual drug therapy while receiving SBRT. The goal is to see if this appr…

This study tests whether adding a precise, high-dose radiation treatment to the liver (L-SABR) to standard immunotherapy can help people with stage IV non-small cell lung cancer that has spread to the liver. About 68 adults will be randomly assigned to receive either standard dru…

This study tests if time-restricted eating (eating only during certain hours) plus coaching calls can help adult survivors of childhood cancer lose weight and lower their risk for heart disease and diabetes. About 300 survivors will either get coaching and a meal schedule or just…

This study aims to help overweight or obese taxi and ride-share drivers lose weight. About 1,785 drivers will receive a combination of counseling, text messages, phone support, and self-monitoring tools. The goal is to find the most effective and affordable way to help this hard-…

This study tests whether placing a tiny radiation source (Cs-131) in the brain during surgery can prevent recurrent brain tumors from growing back. About 103 adults with previously treated brain metastases who need surgery will be randomly assigned to get surgery alone or surgery…

This study is for people with a certain type of prostate cancer that is more likely to come back. The researchers want to see if a precise, high-dose radiation treatment called SBRT can control the cancer without needing hormone therapy. They will also use a special test called D…

This study looks at whether a specific diet can improve how well people with newly diagnosed multiple myeloma respond to standard chemotherapy and enhance their quality of life. About 220 participants will be assigned to a dietary plan or usual care, and researchers will track tr…

This study tests whether adding the immunotherapy drug pembrolizumab to a targeted chemotherapy infusion (ILI with melphalan and dactinomycin) can safely delay cancer growth in people with advanced sarcoma in an arm or leg. About 30 participants aged 12 and older will receive the…

This study is for people with advanced melanoma that has stopped responding to standard immunotherapy. Researchers are testing whether a combination of three drugs—fianlimab, cemiplimab, and ipilimumab—can shrink tumors or slow the cancer's growth. The trial will enroll 88 adults…

This study tests whether combining lenvatinib, pembrolizumab, and fulvestrant is safe and works against ER-positive, HER2-negative breast cancer that has spread. About 54 adults with advanced disease will receive the drug combo. The goal is to find the best dose and see if tumors…

This study tests whether the drug mosunetuzumab, given alone or with zanubrutinib, can effectively treat people who have just been diagnosed with follicular lymphoma and need therapy. About 152 adults with stage II to IV lymphoma will receive the treatment to see if it causes the…

This early-stage study tests whether combining valemetostat with atezolizumab is safe for people with extensive-stage small cell lung cancer (SCLC) after initial treatment. About 24 participants will receive different doses of valemetostat to find the best dose with few side effe…

This study tests whether giving the immunotherapy drug TSR-042 first, followed by standard chemoradiotherapy and surgery, can shrink or eliminate advanced solid tumors that have a specific genetic feature called mismatch repair deficiency (dMMR). About 212 adults with locally adv…

This study looks at whether people with plasma cell disorders can safely recover from a stem cell transplant at home instead of staying in the hospital. About 91 adults will receive their transplant and then be cared for at home or a home-like setting. The goal is to see if this …

This study tests the safety of combining a vitamin A-like drug (bexarotene) with very low-dose radiation to the whole skin for people with a type of skin lymphoma called mycosis fungoides. The goal is to see if giving both treatments together works better than either alone. About…

This study tests whether a cord blood transplant can help children and young adults (up to age 21) with life-threatening blood cancers or genetic blood disorders who do not have a matched family donor. The main goal is to see how many patients survive one year after the transplan…

This study tests whether a single, high-dose session of MRI-guided radiation can control colorectal cancer that has spread to the liver. About 32 adults with up to 3 small liver tumors will receive this treatment. Researchers will track tumor growth, side effects, and look for MR…

This study tests a drug called ZEN003694 in people with advanced squamous cell lung cancer that has a change in the NSD3 gene. The drug blocks certain proteins that may help the cancer grow. Researchers want to see if it can shrink tumors or slow the disease. About 13 participant…

This study compares two approaches to prevent chronic graft-versus-host disease (GVHD) in 40 adults with blood cancers who receive a stem cell transplant. One group gets a lower dose of a standard drug (cyclophosphamide) followed by the drug ruxolitinib, while the other group get…

This study tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). About 55 p…

This study is testing whether a shorter course of radiation therapy (1 week instead of the usual 5 weeks) combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The goal is to see if most participants can comple…

This study tests a drug called tislelizumab in 40 people in Nigeria who have a specific type of colorectal cancer (mismatch repair deficient) and have not had treatment before. The goal is to see if the drug can shrink tumors and is safe. It is a phase 2 trial, meaning it is stil…

This study compares several FDA-approved drugs for non-muscle invasive bladder cancer that has not responded to standard BCG therapy. About 125 adults will receive either a newer gene therapy (nadofaragene firadenovec) or one of several standard treatments. The goal is to see whi…

This early-phase trial tests a new treatment for people with a type of stomach cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goals are to chec…

This study tests a radioactive drug called I-MIBG in people with neuroblastoma or related tumors that have not responded to standard treatments. The drug targets cancer cells directly to deliver radiation. Researchers want to see if it can shrink tumors and how safe it is. About …

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and effective for people with metastatic triple-negative or hormone-receptor-positive/HER2-negative breast cancer. About 34 part…

This study tests whether giving high-precision radiation (SBRT) to all visible cancer spots can delay the disease from getting worse in people with 1 to 5 metastases from breast or lung cancer. About 145 participants will be randomly assigned to receive either standard care alone…

This early-phase study tests whether a radioactive drug called 177Lu-PSMA-617 is safe for people with a fast-growing type of brain cancer (IDH wild type glioma). About 20 adults whose tumors express a protein called PSMA will receive the drug after standard treatments. The main g…

This study tests a new treatment for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. It combines special immune cells (CIML NK cells) with a drug called atezolizumab. The goal is to find a safe dose and see if the combination can …

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Instead of the usual approach of mastectomy, delayed reconstruction, and radiation after surgery, researchers are testing whether giving radiation before surgery allows for im…

This early-stage study tests whether adding abemaciclib to the standard drug ruxolitinib is safe and effective for people with myelofibrosis, a type of bone marrow cancer. About 18 adults who are already on a stable dose of ruxolitinib will take the combination. The main goal is …

This study tests a drug called enfortumab vedotin in people with adenoid cystic carcinoma (ACC) that has spread or come back. The goal is to see if the drug can shrink tumors and how safe it is. About 34 adults with ACC will take part, and researchers will track tumor response an…

This study tests a reduced chemotherapy plan called N10 for children with high-risk neuroblastoma. The goal is to see if it works well and is safe enough to shrink tumors early. About 45 children under 19 with newly diagnosed high-risk neuroblastoma will take part.

This study tests a combination of four drugs (cyclophosphamide, bortezomib, dexamethasone, and daratumumab) for people with kidney disease caused by abnormal proteins from certain blood disorders. The goal is to see if this treatment is safe and can improve kidney function. About…

This early-stage study is testing a new drug called 2141-V11 for safety in 55 people with a type of bladder cancer that didn't get better with standard treatment. The drug is given directly into the bladder through a tube. The goal is to find the safest dose and see how the body …

This study tests a drug called ulixertinib in 38 people with histiocytic neoplasms, a rare group of blood disorders. The goal is to see if the drug can shrink tumors or stop them from growing. Participants will take the drug and be monitored for side effects and response.

This study tests whether combining two drugs, abemaciclib and cabozantinib, is safe and works for people with advanced kidney cancer that has not responded to immunotherapy. About 43 adults with clear cell or translocation-associated kidney cancer will take part. Researchers will…

This study tests whether adding an experimental drug called tinengotinib to standard hormone therapy (abiraterone or enzalutamide) is safe and effective for men with metastatic castration-resistant prostate cancer (mCRPC) — a type of prostate cancer that has spread and stopped re…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can guide decisions to stop maintenance immunotherapy after one year in women with advanced or recurrent endometrial cancer. About 30 participants will receive standard chemotherapy plus immunotherapy for one…

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink tumors in people with advanced head and neck cancer that has gotten worse after first-line therapy. About 40 adults with certain types of head and neck cancer will receive the drug combi…

This early-phase study tests a new drug called CRD3874-SI in people with advanced solid tumors, including sarcoma and Merkel cell carcinoma. The main goal is to find the safest dose and see if it can shrink tumors. About 81 participants will receive different doses to check side …

This study is testing whether a combination of three drugs (avutometinib, defactinib, and letrozole) can shrink tumors in women with low-grade serous ovarian cancer. About 20 women who are not candidates for initial surgery will receive the treatment. The goal is to see how well …

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people whose acute leukemia has returned or not responded to prior treatment. It includes adults and teens aged 12+ with specific genetic subtypes (KMT2A-r, NUP98-r, or NPM1-m). The first part fi…

This study tests whether the drug enfortumab vedotin can safely shrink or eliminate high-grade upper urinary tract cancer before surgery. It is for 24 people who cannot take or choose not to take the standard chemotherapy drug cisplatin. Participants will receive the drug before …

This study tests a combination of two drugs, alectinib and duvelisib, in people with a rare type of blood cancer called ALK-positive anaplastic large cell lymphoma that has come back or not responded to prior treatment. The goal is to find the safest dose and see if the combinati…

This study tests a new treatment called ADCLEC.syn1 CAR T cells for adults whose acute myeloid leukemia (AML) has come back or not responded to standard therapy. The main goal is to find a safe dose that causes few side effects. About 40 participants will receive the cells, and r…

This study tests a targeted radiation therapy called IMPRINT for people with thymic cancer that has spread to the lining of the lung (pleura). The main goal is to see if this treatment is safe and causes few serious side effects, especially lung inflammation. About 36 participant…

This study is for children and young adults with advanced or spreading solid tumors. It tests a new drug called repotrectinib combined with two chemotherapy drugs (irinotecan and temozolomide). The goal is to find the safest dose and see if the combination helps shrink tumors. Ab…

This study tests whether a personalized, lower dose of radiation combined with standard chemotherapy is as effective as the standard full-dose radiation plus chemotherapy for people with HPV-positive throat cancer. About 291 participants will be randomly assigned to one of the tw…

This study tests whether a combination of three drugs—pembrolizumab, olaparib, and temozolomide—can shrink or slow the growth of gliomas that have returned or not responded to earlier treatment. About 57 adults with a specific type of glioma (IDH-mutated, grade II or III) will re…

This study looks at people with a type of advanced lung cancer that has a specific gene change (EGFR mutation). It compares the usual treatment, a pill called osimertinib, with osimertinib plus chemotherapy (carboplatin and pemetrexed). The goal is to see if the combination can k…

This early-stage study is testing a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with solid tumors that have returned or not responded to treatment. The main goal is to find a safe dose and check for side effects. The study is…

This study is for children with high-risk neuroblastoma whose cancer is in complete remission. It tests a bivalent vaccine (with an immune booster called OPT-821) plus an oral supplement called β-glucan to see which schedule of β-glucan works best to strengthen the immune system …

This study tests whether adding the drug BIO 300 to standard chest radiation can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease (lung scarring). About 25 participants will receive both t…

This study tests whether two drugs, azacitidine and venetoclax, can eliminate or reduce leftover leukemia cells (called measurable residual disease) in adults with acute myeloid leukemia who are scheduled for a donor stem cell transplant. About 30 participants will receive the dr…

This study tests whether two drugs, avutometinib and defactinib, can shrink or control thyroid cancers that have a specific genetic change (RAF dimer-driven) and no longer respond to radioactive iodine. The study includes two groups: one with differentiated thyroid cancer and one…

This study tests whether Ivonescimab can safely shrink or control advanced leiomyosarcoma, a rare soft-tissue cancer. About 20 adults who have already tried 1-3 other treatments will receive the drug. The goal is to see if the tumor stops growing or shrinks, while keeping side ef…

This study tests a treatment called obecabtagene autoleucel (obe-cel) for adults with B-cell acute lymphoblastic leukemia (ALL) whose cancer is in complete remission with no detectable cancer cells. The goal is to see if this CAR T cell therapy can help prevent the leukemia from …

This study tests a drug called ASTX727 in people with a rare, aggressive nerve sheath tumor (MPNST) that has a specific genetic change (PRC2 loss). The drug combines two medicines to better attack cancer cells. About 25 adults and teens aged 16+ with advanced tumors that have wor…

This study tests whether giving immune-suppressing drugs before a stem cell transplant can reduce serious side effects like graft failure and graft-versus-host disease. It includes adults and children aged 2 to 50 with sickle cell disease or beta-thalassemia who have a half-match…

This study is for people with metastatic cancer that has spread and who have a specific genetic change called an ATM mutation. Researchers want to see if a lower dose of radiation can still effectively control these tumors. About 45 participants will receive reduced-dose radiothe…

This study looks at people with a type of lung cancer (NSCLC) that has spread to the brain. They are already taking a targeted pill (osimertinib). The researchers want to see if adding a precise, one-time radiation treatment (SRS) after 3 months of the pill is better than just co…

This study is for people with a type of blood cancer called acute myeloid leukemia (AML) that has come back or not responded to treatment. The cancer must have specific gene changes (FLT3 and IDH1 or IDH2). The study tests a combination of two targeted drugs (gilteritinib plus iv…

This study tests whether a three-drug combination (ivosidenib, azacitidine, and venetoclax) followed by maintenance therapy with ivosidenib alone can help keep acute myeloid leukemia (AML) with an IDH mutation from coming back. It includes 45 adults aged 60 or older with newly di…

This study is for people aged 65 and older with diffuse large B-cell lymphoma (DLBCL) or similar lymphomas. The goal is to see if adding the drug glofitamab to standard chemotherapy can improve treatment results with fewer side effects. About 42 participants will receive a combin…

This study tests whether switching between two different drug combinations can safely and effectively treat people newly diagnosed with multiple myeloma. About 65 participants will receive one combination for 3 cycles, then switch to another for 3 more cycles. The goal is to see …

This study tests different doses of the drug abemaciclib given together with radiation therapy for people with advanced hormone receptor-positive, HER2-negative breast cancer that has spread to the bone. The goal is to find the safest dose of abemaciclib when used alongside stand…

This study tests a drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD-1 and VEGF) to help the immune system fight the cancer and cut off its blood supply. The main goal…

This early-phase study tests a drug called codrituzumab in children and young adults (ages 1 to 21) whose solid tumors have returned or not responded to treatment and carry a specific protein called GPC3. The main goal is to see if the drug is safe and how the body processes it. …

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil alongside their usual GVHD prevention medicine…

This study tests whether combining two drugs, epcoritamab and ibrutinib, is safe for people with central nervous system (CNS) lymphoma that has returned or not responded to treatment. About 26 adults with this rare brain cancer will take part. The main goal is to find the best do…

This study tests whether a new treatment called irreversible electroporation (IRE), which uses electrical pulses to destroy cancer cells, works as well as the standard radiation boost for men with intermediate-risk prostate cancer. About 224 participants will receive standard ste…

This study tests if the drug elacestrant, alone or with abemaciclib, can shrink tumors in people with advanced or recurrent ER+ endometrial cancer. About 75 adults who have already tried platinum chemo and an immunotherapy will take part. The goal is to see how many patients resp…

This early-phase trial tests a new type of CAR T-cell therapy for adults with acute lymphoblastic leukemia that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified in a lab to better target and kill leukemia cells. The main goal is…

This study looks at whether giving hormone therapy before surgery can lower the chance of cancer cells being found at the edges of removed tissue in women with stage 2 to 3 invasive lobular breast cancer. About 176 postmenopausal women with ER+/HER2- tumors will receive neoadjuva…

This study tests two treatments (emapalumab or fludarabine plus dexamethasone) to reduce inflammation before a stem cell transplant in people with primary immune regulatory disorders. The goal is to help the donated stem cells settle in and start making healthy immune cells. Abou…

This study tests whether a drug combination called BV-AVD works well for people with newly diagnosed, early stage, bulky Hodgkin lymphoma. BV is a targeted therapy that seeks out and kills cancer cells, while AVD is a standard chemotherapy regimen. The trial will enroll 71 adults…

This early-stage study tests whether combining teclistamab and mezigdomide is safe and works for people with multiple myeloma that has returned or not responded to prior treatments. About 18 adults who have already tried at least two other therapies will take part. The main goal …

This study is testing a lower dose of the drug brentuximab vedotin in people with mycosis fungoides, Sezary syndrome, or lymphomatoid papulosis—types of lymphoma that affect the skin. The goal is to see if the lower dose works as well as the standard dose but with fewer side effe…

This study tests whether adding an experimental immune-boosting drug (retifanlimab) to standard chemotherapy (gemcitabine and docetaxel) can help control advanced soft tissue sarcoma that has spread or cannot be removed by surgery. About 98 adults with this rare cancer will recei…

This study tests if a special program can prevent lymphedema (arm swelling) in women having lymph node removal for breast cancer. About 285 women will be followed for at least a year to see if the program reduces swelling and improves quality of life. The goal is to find a better…

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This study tests whether giving lower doses of radiation (fewer treatments over a shorter time) along with standard chemotherapy can effectively treat HPV-positive throat cancer. About 74 people with advanced-stage disease will take part. The goal is to see if this gentler approa…

This study tests whether using a special camera and fluorescent dye during surgery can help surgeons see blood flow in the bowel and reduce the risk of leaks after the operation. About 310 women with ovarian cancer who need bowel surgery will take part. The goal is to see if this…

This study tests whether combining ivonescimab with either Dato-DXd or osimertinib is safe and works for people with advanced EGFR-mutant non-small cell lung cancer that stopped responding to previous treatments. About 66 adults will join to find the best dose and check if tumors…

This study is for people with HPV-positive throat cancer. It tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) to control the cancer, while causing fewer side effects. About 121 participants will …

This study is for women with a specific type of endometrial cancer (MMR-D/MSI-H) who have had surgery. It tests whether adding radiation and an immunotherapy drug called Dostarlimab can help keep the cancer from returning. About 62 participants will receive the combination treatm…

This study tests whether giving a personalized dose of the chemotherapy drug fludarabine before CAR T-cell therapy can improve outcomes for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 130 participants will be randomly assign…

This early-phase study tests a new treatment called CD371-YSNVZ-IL18 CAR T cells for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The main goal is to find the safest dose and see what side effects occur. About 15 participants w…

This study is testing whether adding two targeted drugs, pembrolizumab and trastuzumab, to standard chemotherapy can improve outcomes for people with HER2+ esophageal or stomach cancer that can be surgically removed. The treatment is given before surgery to shrink the tumor. The …

This study tests whether giving two drugs—enfortumab vedotin and pembrolizumab—before bladder cancer surgery can eliminate cancer in the lymph nodes and shrink tumors. About 23 adults with advanced bladder cancer that has spread to lymph nodes will receive the combination before …

This study tests whether aggressively lowering blood pressure during breast cancer treatment is safer and more effective than standard care at preventing heart damage. About 130 women with breast cancer and high blood pressure will be assigned to either intensive or standard bloo…

This study is for people with a certain type of advanced rectal cancer called HER2-positive. Researchers are testing whether adding two targeted drugs, tucatinib and trastuzumab, to standard chemotherapy can shrink tumors more effectively before surgery or radiation. About 37 adu…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This study tests the safety and effectiveness of combining two drugs, lorlatinib and ramucirumab, for people with advanced ALK-rearranged non-small cell lung cancer. Researchers will first find a dose that causes few side effects, then see if that dose helps control the cancer. U…

This study tests whether using Tumor-Treating Fields (TTFields) before surgery is safe and practical for people with early-stage lung adenocarcinoma. About 25 participants will receive the treatment before their tumor is removed. Researchers also want to see if it helps the immun…

This study tests a technique called acute normovolemic hemodilution (ANH) during ovarian cancer surgery. Before surgery, some blood is removed and replaced with fluids, then returned later. The goal is to see if this reduces the need for donor blood transfusions. About 86 adults …

This study tests a drug called tarlatamab in people with a specific type of advanced prostate cancer (DLL3-positive) that has spread and either came back or didn't respond to prior treatments. About 32 participants will receive the drug to see if it can shrink tumors or slow the …

This early-phase study tests a new cell therapy called MB-CART19.1 for people with central nervous system lymphoma (CNSL) that has returned or not responded to standard treatments. The therapy uses a patient's own immune cells, modified to attack cancer, and is made on-site. The …

This study tests if adding ulixertinib to the standard drug ruxolitinib is safe and works for people with myelofibrosis, a type of bone marrow cancer. About 37 adults who are already on a stable dose of ruxolitinib will join. The goal is to find the best dose of ulixertinib that …

This program provides access to an experimental drug called L-MTP-PE for people with osteosarcoma, a type of bone cancer. The drug works by activating white blood cells to help the immune system kill cancer cells. It is available to patients of any age who have had surgery to rem…

This study tests a special PET scan that uses a radioactive tracer to find a protein called DLL3 on small cell lung cancer cells. The goal is to see if this imaging method is safe and can show where the cancer is in the body. About 53 people with small cell lung cancer or similar…

This study aims to detect pancreatic cancer early in 25 people with high-risk pancreatic cysts using a combination of special PET and MRI scans along with blood tests. The goal is to avoid unnecessary surgery by identifying cancer without invasive procedures. Participants will un…

This study tests whether using mobile health (mHealth) tools helps find oral cancer and pre-cancer earlier than traditional screening methods. Over 5,000 adults in rural Varanasi, India, who smoke, chew tobacco, or drink alcohol will be screened. The goal is to improve early dete…

This early-stage study tests whether a special tracer made of tiny silica nanoparticles can safely help identify prostate cancer cells before and during surgery. The tracer is designed to attach to cancer cells and show up on both PET/MRI scans and a special camera used in the op…

This study is testing whether special PET scans using radioactive tracers can better detect where prostate cancer has spread in the body. Researchers will compare these scans to standard imaging like CT and bone scans. The goal is to improve how doctors find cancer locations, not…

This study trains Nigerian radiologists to perform ultrasound-guided breast biopsies using portable tablet devices. The goal is to make breast cancer diagnosis more accessible in areas with limited resources. About 900 women with suspicious breast lumps will take part to help eva…

This study is testing a new type of PET scan that uses a special radioactive form of iodine called iodine-124. The scan measures how much radioactive iodine the cancer absorbs, which helps doctors decide if standard radioiodine therapy will work. If the scan shows low uptake, doc…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection and moni…

This study tests if a special antibiotic material called Stimulan Rapid Cure can lower the chance of infection in women who get temporary breast expanders after mastectomy. About 392 women will take part, and half will get the antibiotic placed in the surgical site. The goal is t…

This study looks at whether starting sexual health counseling and using a non-hormonal moisturizer right away can prevent or reduce vaginal dryness and sexual problems in premenopausal women with breast cancer who are receiving ovarian suppression. About 50 women will take part, …

This study tests whether watching an educational video can increase women's interest in a preventive surgery called opportunistic salpingectomy (removing the fallopian tubes) to lower their risk of ovarian cancer. About 266 women aged 45 and older who are at average risk will wat…

This study tests whether the drug mogamulizumab can prevent adult T-cell leukemia/lymphoma (ATL) in people infected with HTLV-1 who are at higher risk due to changes in their T-cells. About 134 participants will receive a limited course of the drug to see if it reduces the virus …

This study is testing a family-centered program to help Hispanic families lose weight and prevent obesity. Parents and their children ages 8-12 will work together to build healthy habits. The goal is to find the best way to support families using text messages and other tools.

This study tests if a precise, one-time radiation treatment (stereotactic radiosurgery) can safely reduce chronic pain in the chest or belly wall. It involves 18 adults whose pain has lasted at least 3 months and hasn't been helped by standard medicines. Researchers will try diff…

This study tests a new 5-session phone therapy called CARE for older adults (70+) with cancer who feel depressed or distressed. It compares CARE to standard supportive counseling. The goal is to see which approach better improves mood and reduces anxiety.

This study tests a special anxiety treatment program for Latino adults aged 65 and older who have cancer, and for their caregivers. The program is designed to be practical and helpful for this group. Researchers want to see if people can complete all parts of the program and if i…

This study looks at whether acupuncture is a practical way to help cancer survivors with long-term joint pain. Researchers will enroll 60 adults from diverse backgrounds who have had cancer and still have pain. The main goal is to see if offering acupuncture in community settings…

This study tests a special mental health program called DESCANSO/REST for Spanish-speaking Latino cancer patients who feel depressed, have trouble sleeping, or are very tired. The program is delivered through telehealth (video or phone calls) and includes up to 8 sessions. Resear…

This study tests a new radiation technique called lattice radiation therapy (LRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better than standard radiation and whether it helps the immune system attack cancer cells. Abo…

This study is testing a culturally tailored counseling program for Latinos with advanced cancer. The goal is to improve their quality of life and emotional well-being. About 285 adults who speak Spanish or both Spanish and English will take part. Researchers will measure changes …

This study tests whether a virtual mind-body program called IM@Home can reduce fatigue and improve quality of life for adults with head and neck, thoracic, gynecologic, or other cancers who are receiving treatments like chemotherapy or radiation. About 480 participants will be en…

This study compares two types of group therapy to see which better helps breast cancer survivors manage joint pain caused by aromatase inhibitors (a common hormone therapy). About 200 women who have had breast cancer and are currently on this medication will join weekly 2-hour se…

This study looks at whether offering mental healthcare early during sarcoma treatment can help reduce depression and anxiety and improve quality of life. About 60 adults with bone or soft tissue sarcoma who are scheduled for surgery will take part. Researchers will check how many…

This study tests two walking programs for women undergoing chemotherapy for early-stage breast cancer. One program has a fixed weekly walking goal, while the other adjusts the amount of walking based on how each woman responds. The goal is to see which approach better improves ca…

This study tests whether a combination of two drugs (propranolol and etodolac) plus mind-body training and music therapy can reduce stress in women with advanced ovarian cancer undergoing surgery. About 35 participants will be randomly assigned to receive this bundle or standard …

This study is testing a mobile app called TEAMWork that gives breast cancer patients advice on how to talk to their employers and doctors about work. The goal is to help patients keep their jobs during and after treatment. About 546 adults with breast cancer who are about to star…

This study looks at whether acupuncture can help young women (ages 15-40) whose periods stopped after chemotherapy for cancer. Researchers will check if it's practical to offer acupuncture and whether it helps restart menstruation and improve quality of life. Participants will re…

This study tests a program called ICCAN that provides extra support to cancer patients. Researchers want to see if it helps patients complete their chemotherapy or radiation therapy and improves their quality of life compared to standard hospital services. About 347 adults with c…

This study looks at whether different amounts of aerobic exercise (like walking or cycling) can help people with stomach or bowel cancer better tolerate chemotherapy. Researchers want to find a safe and practical exercise level that reduces side effects and helps patients complet…

This study tests different combinations of education, counseling, and peer support for Chinese cancer patients and survivors. Researchers want to see which mix is practical and helps improve quality of life. The study involves 64 participants who speak Mandarin and live in New Yo…

This study tests whether adding local anesthesia during a prostate biopsy, while patients are already sedated, reduces pain after the procedure. Researchers will compare pain scores and recovery times between those who get the extra numbing and those who don't. About 800 men sche…

This study tests whether injecting a fluorescent dye called fluorescein sodium before surgery helps surgeons better see and remove extramammary Paget's disease cells during vulvectomy. About 27 adults with noninvasive or microinvasive disease will receive the dye, and researchers…

This study tests whether giving the steroid methylprednisolone before major liver surgery can lower the chance of problems like infections and shorten hospital stays. About 750 adults having elective major liver removal will be randomly assigned to receive either the steroid or s…

This study looks at how different amounts of aerobic exercise (like walking or cycling) affect heart and lung fitness in post-menopausal women who had early-stage breast cancer. About 152 women will take part, comparing exercise programs of varying lengths and frequencies. The go…

This study explores whether a Hospital-at-Home program can safely and effectively monitor people with small cell lung cancer after they receive the drug tarlatamab, instead of keeping them in the hospital. About 70 adults will be enrolled. The goal is to see if this approach redu…

This early-phase study tests a live bacterial treatment called SER-155 for people who develop diarrhea and colon inflammation from cancer immunotherapy. The goal is to see if it is safe and can reduce symptoms without needing strong immune-suppressing drugs. About 15 adults will …

This study tests whether giving the drug pembrolizumab after standard radiation therapy is safe for people with advanced adrenocortical carcinoma (a rare adrenal gland cancer). The trial will enroll 12 participants and focus on tracking side effects. The goal is to see if this co…

This study tests two different approaches to help men recover sexual function after prostate cancer surgery. It involves 224 men who had their prostate removed within the past 9 months. The goal is to see which method works better for improving erectile function.

This study tests whether a special light device (photobiomodulation) can safely reduce mouth sores caused by chronic graft-versus-host disease, a common complication after stem cell transplants. About 44 people aged 4 and older who have not improved with standard treatments will …

This study tests whether eating a high-fiber, plant-based diet (fruits, vegetables, nuts, beans, whole grains) can improve quality of life for people with clonal hematopoiesis (CH), a blood condition. About 36 participants will complete surveys to measure changes. The goal is to …

This study aims to adapt a counseling approach called Meaning Centered Psychotherapy to better support Latinos with advanced cancer. Researchers will work with 190 participants to see if the culturally tailored program improves spiritual well-being and eases anxiety and depressio…

This study looks at whether giving gabapentin before and after mastectomy can improve pain control and reduce the need for stronger opioid painkillers. About 1,896 adults having mastectomy at a single center will take part. The goal is to see if gabapentin should become a standar…

This study tests whether an herbal formula called MZRW can help cancer survivors who have constipation. About 70 adults who have finished cancer treatment at least a month ago will take either MZRW or a placebo pill for 2 weeks. Researchers will check if bowel movements improve a…

This study tests whether a new 3D technology can help surgeons use standard scans (like CT or MRI) more effectively during head and neck surgery. About 27 adults scheduled for surgery will have a 3D image created using the Scaniverse app during a standard ultrasound. The goal is …

This study tests a software tool that uses DNA from a blood sample to predict if a cancer patient's blood clot is likely to return after stopping blood thinners. About 259 adults who have finished 3-12 months of blood thinner therapy will be followed for 6 months. The goal is to …

This study aims to understand how skin conditions related to cancer or cancer treatments impact the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to learn how to better treat these skin i…

This study aims to understand how rectal cancer responds to standard treatments like chemoradiation and chemotherapy. Researchers will analyze participants' blood, tissue, and scans to see if these tests can predict whether the cancer improves, worsens, or stays the same. The stu…

This study looks at how women with BRCA1 or BRCA2 gene mutations react to additional genetic testing that may show their risk of breast cancer more precisely. Researchers want to understand how this information affects decisions like getting preventive mastectomy or choosing regu…

This study looks at tiny particles called exosomes in the blood and tissue of people with pancreatic cancer and those with noncancerous pancreatic disease. The goal is to understand how these messengers might be linked to cancer coming back and patient outcomes. About 181 adults …

This study looks at whether giving cancer patients an indoor air quality monitor can help them keep their homes smoke-free. Ten patients who smoke and are already in a tobacco treatment program will use the monitor for two weeks. The goal is to see if the device is easy to use an…

This study is for women 18 and older who have a suspicious breast finding or a new breast cancer diagnosis. Researchers will collect tissue and blood samples and ask participants to fill out questionnaires during their regular care. The goal is to learn more about what factors af…

This study is building a registry of 3,200 people with early stomach changes that can lead to cancer, such as gastric atrophy or intestinal metaplasia. Researchers will also include healthy people and those with stomach cancer for comparison. The goal is to learn which risk facto…

This study follows 1,250 women who have had lymph nodes removed during breast cancer surgery to see how many develop lymphedema (arm swelling). Researchers will look at breast tissue for signs of inflammation that might raise risk, and ask participants about their quality of life…

This study looks back at the medical records of 4000 people who had surgery for esophageal cancer. The goal is to learn how the edges of removed tissue (called margins) relate to how long patients live. No new treatments are given; instead, researchers hope to find patterns that …

This study looks at two new approaches to cancer genetic counseling. The first part (EfFORT) tests whether having healthcare providers directly contact family members of people with harmful gene changes leads to more genetic testing, compared to the usual method of patients telli…

This study is testing a new breath test (called an electronic nose or E-Nose) to see if it can measure how people with malignant pleural mesothelioma respond to standard treatment. About 20 adults aged 30-85 with a recent diagnosis will provide breath samples before and during tr…

This study is looking at how well cardiac MRI scans can help doctors understand blood clots that form in the right atrium of the heart due to central venous catheters in cancer patients. The goal is to learn more about these clots so doctors can choose the best treatments. About …

This study looks at whether exercise can help prevent cancer from coming back in adults who have already had cancer. Researchers will review data from 1,000 cancer survivors to compare those who exercise with those who don't. The goal is to see if staying active is linked to bett…

This study tests whether training oncology care providers (doctors, nurse practitioners, and physician assistants) in empathic communication skills can reduce the stigma lung cancer patients often feel during medical visits. About 1,232 providers across the U.S. will be trained a…

This study collects blood, tissue, and stool samples along with health information from 160 people aged 18-49, both with and without young onset colorectal cancer. Researchers will analyze the samples to better understand what causes this cancer in younger adults. The goal is to …

This study tests new ways to use MRI and CT scans to plan and monitor radiation therapy more effectively. It involves 837 adults who are already scheduled for radiation treatment. The goal is to improve imaging techniques, not to change the treatment itself.

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma. Researchers will collect DNA and blood samples from people who have these cancers and their family members. No treatment is given—the goal is to learn more about why…

This study aims to develop and test a new MRI technique that may help doctors tell the difference between actual tumor growth and changes caused by radiation treatment in people with brain metastases. About 119 participants, including healthy volunteers and patients, will undergo…

This study is testing whether a decision aid tool called RECONJOINT can help women with breast cancer or a genetic risk make informed choices about breast reconstruction after mastectomy. Researchers want to see if it's practical to run a larger study on this tool. About 131 part…

This study is testing new MRI techniques to get more detailed information about head and neck and thyroid tumors. Researchers will compare these new scans with standard follow-up data to see if they can better predict how a tumor responds to treatment. The study involves 200 adul…

This study looks at how men aged 45-70 with BRCA1/2 gene mutations respond to additional genetic risk testing for prostate cancer. Researchers want to understand how this information affects their decisions about prostate cancer screening and their emotional reactions. The study …

This study aims to safely collect health information from wearable devices (like smartwatches) from over 3,600 people with solid tumors. Researchers will use this data to explore how things like heart rate and activity levels relate to cancer diagnosis, treatment response, and ri…

This study is testing a new type of ultrasound called multiparametric ultrasound (mpUS) to see if it can give doctors more detailed information about tissue in the pancreas and thyroid. Researchers will compare mpUS images to standard ultrasound and other tests. The goal is to le…

This study is building a DNA registry for kidney cancer. Researchers will collect health information and genetic samples from 750 people, including patients, their family members, and healthy volunteers. The goal is to find better ways to prevent, diagnose, and treat kidney cance…

This study is testing whether noninvasive imaging methods can help doctors diagnose skin and mouth lesions more accurately before deciding on a biopsy. Researchers will collect images from up to 5,010 participants, including healthy volunteers and patients with lesions, using a s…

This study is a registry that collects information from people with large dark skin patches present at birth (LCMN) or a rare brain condition called neurocutaneous melanocytosis (NCM). Researchers aim to gather data worldwide on how these conditions are treated and how they progr…

This study creates a registry of people with germ cell or testicular tumors, along with their relatives and unrelated volunteers. By collecting medical and family history, researchers hope to understand why some people develop these tumors and others don't. The goal is to improve…

This early-phase study is testing a new imaging agent called [68Ga]-pentixafor to see how well it lights up certain blood cancers and related disorders on PET/CT scans. About 30 adults with non-Hodgkin lymphoma, multiple myeloma, or histiocytic neoplasms will receive the agent an…

This study looks at how memory, attention, and thinking skills change over time in women aged 60-80 who are long-term breast cancer survivors, compared to healthy women of the same age. Researchers will use computer tests to measure mental function and also check smoking exposure…

This study looks at how BRCA gene changes and cancer treatments impact the ovaries in premenopausal women with early-stage breast cancer. Researchers will measure hormone levels in the blood before, during, and after treatment to understand who is at higher risk for early menopau…

This study aims to see if a new telehealth program can safely reduce the number of in-person doctor visits for people with breast or prostate cancer. About 1,750 participants will be assigned to either enhanced telehealth or standard care. The goal is to make cancer care more con…

This study tracks how much radiation doctors are exposed to while performing robotic-assisted lung biopsies. About 350 doctors will wear a special badge to measure their exposure over 50 procedures. The goal is to understand and improve safety for medical staff.

This study is testing whether daily voice recordings made on a smartphone can help doctors spot early signs of a brain-related side effect called ICANS in people receiving CAR T-cell therapy for non-Hodgkin lymphoma or multiple myeloma. About 20 participants will record their voi…

This study aims to find out which small thyroid cancers (papillary microcarcinomas) are likely to grow and become problematic. Researchers will analyze genetic and clinical features from 750 adults whose tumors are being monitored without immediate treatment. The goal is to bette…

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial parts. Researchers will measure how well the bone heals and how much function returns over 3 years. The goal is to learn more about recovery after these…

This study tests a program that screens cancer patients for emotional distress and refers them to mental health services. It involves 50 English- or Spanish-speaking adults with a new solid tumor cancer diagnosis at Jamaica Hospital Medical Center. The goal is to see if the progr…

This study is working on a new, less invasive test to find pancreatic cancer at an early stage and to see how well treatment is working. Researchers will study 700 people with pancreatic cancer or related conditions to find biological markers in the blood or tissue. The goal is t…

This study creates a database of health information from up to 250 people with desmoplastic small round cell tumor (DSRCT), a rare cancer. Participants of any age can join by sharing their medical history and ongoing health data. The goal is to help researchers learn more about D…

This study is collecting information from 600 people with early-stage lung cancer who are having a type of surgery called pulmonary segmentectomy. Participants fill out questionnaires before surgery, a few weeks after, and 6 months later. The goal is to learn how many people rema…

This study is developing and testing a training program called Hematolo-GIST to help doctors talk with patients about their large B-cell lymphoma diagnosis and plan future care. About 48 people, including doctors and their patients, will take part at Memorial Sloan Kettering Canc…

This study is adapting a program called CONVO for Spanish-speaking Latinx cancer patients. In the program, nurses and patients talk about the patient's personal values during routine cancer care. The goal is to make sure care aligns with what matters most to each patient.

This study looks at how CAR-T cell therapy for lymphoma might affect thinking skills like memory and concentration, as well as brain structure and function. Researchers will follow 120 adult patients over time using tests and brain scans. The goal is to better understand these ch…

This study looks at whether people with unexplained weight loss are more likely to have or develop lung cancer. Researchers will use low-dose CT scans and blood tests to screen 409 participants. The goal is to see if adding weight loss as a risk factor can catch lung cancer earli…

This study watches how older patients (age 60 and up) with certain blood cancers handle standard CAR-T cell therapy and how it changes their daily life and thinking skills. No extra treatment is given—just careful checkups. The goal is to see if patients can complete all planned …

This study looks at whether taking a small tissue sample (biopsy) right after a tumor-killing procedure (ablation) can detect cancer cells that survived. The goal is to see if this information can help doctors decide on the next treatment. The study involves 200 adults with liver…

This study looks at how a short-term plant-based diet or supplements (omega-3, curcumin, or probiotics) change levels of butyrate—a healthy gut substance—in people with smoldering multiple myeloma or MGUS. About 200 participants will be assigned to one of the diet or supplement g…

This study tracks 120 young adults (women under 40, men under 50) with early-onset colorectal cancer to see how chemotherapy and radiation affect their hormone levels, sexual health, and ability to have children. Researchers will measure changes in key hormones over time. The goa…

This study tests whether advanced MRI scans can better identify parts of a brain tumor (glioma) that are likely to grow back after standard treatment. Researchers will compare these scans with usual methods to design safer, more targeted radiation plans. About 135 adults with sus…

This study is creating a large database of information from 1,000 people with T-cell lymphoma. Researchers will collect medical records and tumor samples to learn more about the disease and how to improve care. No new treatments are being tested; the goal is to gather data for fu…

This study looks at how much of the drug T-DXd gets into brain tumors in people with HER2-positive brain cancer or glioblastoma. About 30 adults will receive the drug before surgery, and researchers will measure drug levels in the tumor during the operation. The goal is to unders…

This study is testing whether a new type of MRI scan, which uses a special imaging agent called hyperpolarized pyruvate, gives the same results each time it is used in the same person. About 109 people with solid tumors will have two of these scans to check for consistency. The g…

This study follows 1715 people with early-stage endometrial cancer to see how often the cancer comes back and how often standard treatment causes lymphedema (arm or leg swelling). Participants are checked every 6 months for 3 years. The goal is to better understand the real-world…

This study tests whether a special ultrasound (mpUS) can measure vaginal tissue changes after internal radiation (IVRT) for endometrial cancer. Ten participants will have scans before and after treatment to see if the method works. The goal is to better understand and possibly pr…

This study aims to find new genetic changes that increase the risk of inherited cancers in both children and adults. Researchers will analyze DNA from up to 1,500 people who have or may develop hereditary cancer. The goal is to discover new susceptibility genes, which could lead …

This study looks at how a drug called enfortumab vedotin affects the nerves of people with advanced bladder cancer that has spread. Researchers will measure nerve function with simple tests before and during treatment. The goal is to better understand nerve damage caused by the d…

This study tracks over 1,300 people with blood cancers like acute leukemia to see how many receive a stem cell transplant and why some do not. Researchers want to understand the medical and personal reasons behind these decisions. The goal is to identify barriers so more patients…

This study aims to understand the genetic and biochemical makeup of neuroblastic tumors, which are a type of childhood cancer. By analyzing tumor samples and blood from over 2000 participants, researchers hope to link these molecular features with how the disease behaves and resp…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback on the m…

This study creates a registry for up to 500 people with Erdheim-Chester disease and other histiocytoses. Researchers will collect health information, treatment details, and patient experiences over time to better understand these rare conditions. Some participants may also be ask…

This study looks at whether a new DNA test on spinal fluid can find signs of lymphoma spreading to the brain before standard tests do. About 50 people with aggressive B-cell lymphoma at high risk for brain relapse will give spinal fluid samples during their first treatment. The g…

This study aims to find abnormal genes (mutations) in cancer cells using leftover tumor tissue from past surgeries or biopsies. Participants also give a blood, cheek swab, or saliva sample for comparison. The goal is to learn which mutations matter for cancer survival and how the…

This study compares three types of remote medical interpreting to see which leads to the fewest errors during breast cancer appointments. It involves 700 Spanish- and Mandarin-speaking patients with limited English proficiency and their English-speaking doctors. The goal is to fi…

This study is creating a registry of 300 people with Cushing's syndrome to follow their health over time during routine care. Researchers will collect data before and after treatments like surgery, medication, or radiation to understand long-term outcomes. The goal is to learn mo…

This study is collecting information from 100 adults with a type of thyroid cancer that does not respond to standard radioactive iodine treatment. Doctors are using special medications called redifferentiating agents to try to make the cancer respond to radioactive iodine again. …

This study looks at how radiation from a procedure called Y90 radioembolization damages liver tumors that have spread from colorectal cancer. Researchers will take small tissue samples (biopsies) from the tumors after treatment to see how much cell death and injury occurs. The go…

This study follows 100 people with desmoid-type fibromatosis (a type of non-cancerous tumor) for 12 months to see how the disease progresses without any active treatment. Participants receive regular scans and check-ups. The goal is to understand the natural course of the disease…

This study creates a database of information from people diagnosed with colorectal cancer before age 50. Researchers will use this data to compare young-onset and later-onset colorectal cancer, and to guide future research. About 1,366 participants will provide medical informatio…

This study is testing a new, non-invasive technology called an electronic nose (E-nose) that analyzes chemicals in a person's breath. Researchers want to see if these breath 'fingerprints' can accurately show how well lung cancer responds to treatment and if the cancer comes back…

This study compares a new, advanced eye scanner to a standard one for taking pictures of eye tumors. The goal is to see which device gives clearer and wider images to help doctors better detect and monitor these tumors. About 60 adults with an eye tumor will have both scans to se…

This study aims to learn why breast cancer risks and outcomes vary among different people. Researchers will collect blood, tissue samples, and survey data from 800 adults in South Florida. The goal is to find genetic and non-genetic factors that may explain these differences.

This study looks at how a gene called BRCA2 affects the way breast cancer responds to hormone therapy before surgery. Researchers will compare changes in a tumor marker called Ki67 in women with and without the BRCA2 mutation. The goal is to learn whether these two groups respond…

This study follows 475 women with breast cancer or lymphoma to see how cancer treatments impact their sexual health and ability to have children. Participants will fill out questionnaires and may also choose to give blood samples to measure ovary function. The goal is to better u…