MGMT-unmethylated glioblastoma (GBM)

Clinical trials for MGMT-unmethylated glioblastoma (GBM) explained in plain language.

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Not yet recruiting 1

Can a drug duo prime the brain to fight aggressive tumors?

Disease control Not yet recruiting

This trial is testing whether two oral drugs, avutometinib and defactinib, can be safely given to people with newly diagnosed high-grade gliomas, a type of aggressive brain cancer. Participants first take the drugs for one cycle before starting standard radiation, and those with …

Matched conditions: MGMT-UNMETHYLATED GLIOBLASTOMA (GBM)

Early phase 1 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control

Last updated Aug 28, 2026 00:00 UTC

MGMT-unmethylated glioblastoma (GBM)

Get alerted when new MGMT-unmethylated glioblastoma (GBM) trials appear

Can a drug duo prime the brain to fight aggressive tumors?