DIABETES

This study tests a program that connects rural diabetes patients with community services to help with food, housing, utilities, transportation, and safety. About 12,000 adults with diabetes in two Kentucky communities will take part. The goal is to see if linking clinics with loc…

This study tests a new automated ultrasound system (EchoMark/EchoSure) to see if it can help blood vessel connections (fistulas) mature faster in people with kidney failure who need dialysis. About 304 adults will be randomly assigned to get the automated scans or standard care. …

This study tests a mobile health app that gives older adults with diabetes real-time, personalized advice to help them manage their condition. The goal is to see if the app improves blood sugar levels and self-care habits compared to standard care. About 184 participants who alre…

This early-stage trial tests placing insulin-producing cells into the front chamber of the eye to help control diabetes. Only 2 participants with severe vision loss in one eye will receive the transplant, along with lifelong immunosuppressive eye drops. The main goal is to check …

This study tests a new glucose sensor (ROME GS) to see if it is as accurate and safe as an existing sensor. It involves 60 adults with type 1 or type 2 diabetes. The sensor measures glucose levels continuously, and researchers will check for any side effects or errors.

This study compares three different programs to help pregnant women maintain a healthy weight. About 795 women at risk for obesity or diabetes will receive nutrition and exercise counseling, plus help overcoming barriers like food access. The goal is to see which approach works b…

This study looks at whether weight-loss surgery can help people with severe obesity and type 2 diabetes achieve long-term remission better than the best medical care alone. About 408 participants will be followed to see how surgery affects diabetes, kidney function, and heart hea…

This study looks at how well the Omnipod 5 automated insulin delivery system works for people with type 1 diabetes in their daily lives. About 304 participants aged 2 and older will use the system for the first time. Researchers will measure blood sugar control, quality of life, …

This study tests a program that combines home blood pressure monitors, a mobile app, community health workers, and pharmacist support to help adults with uncontrolled high blood pressure plus diabetes or kidney disease. About 425 participants from 16 clinics will either get usual…

This study compares two ways to check blood sugar in adults with diabetes who are starting insulin for the first time when leaving the hospital. Half will wear a continuous glucose monitor (CGM) for two weeks, and the other half will use standard finger-stick testing. The goal is…

This study tests whether a daily tablet of semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside standard care. The goal is to see if the …

This study tests a diabetes management program called Together Overcoming Diabetes (TOD), designed specifically for Lakota and other American Indian/Alaska Native communities. About 140 adults with type 2 diabetes who care for a young person aged 10-25 will take part. The program…

This study tests whether a weekly injection of dulaglutide (a GLP-1 drug) can improve early insulin release and blood sugar control in adults with cystic fibrosis who have pancreatic insufficiency and abnormal glucose tolerance. About 30 participants will receive the drug or no d…

This study is for overweight or obese adults with type 1 diabetes whose blood sugar is not well controlled with insulin alone. Researchers want to see if adding empagliflozin or semaglutide to insulin can lower blood sugar levels over 3 months. About 105 participants will be rand…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck on the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist support, community health worker support, o…

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take the supplement and undergo tests like e…

This study tests a pharmacy-led program to help low-income people with chronic conditions like diabetes and heart disease take their medicines after leaving the hospital. The program provides free medicines, delivers them to the bedside and home, and offers coaching to overcome b…

This study looks at whether whole or nonfat milk is better for body fat, heart health, and diet in 200 children aged 9-12 who have a higher BMI. Participants drink either whole or nonfat milk for one year while researchers measure changes in fat mass, lean mass, and other health …

This study tests a new long-acting insulin called GZR4 against another insulin (Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may …

This study aims to find the most effective way to screen for diabetes in people who take glucocorticoids (steroids) for more than three months. Steroids can raise blood sugar and cause diabetes, but current screening methods vary. Researchers will compare three tests—fasting bloo…

This study tests whether a wearable breath sensor can detect high or low blood sugar (hyperglycemia or hypoglycemia) in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while their blood sugar is measured. The goal is to find a noni…

This study tests an AI software called iPredict-DR that looks at photos of the retina to find early signs of diabetic retinopathy, a leading cause of blindness. The goal is to see if the AI can detect the disease as accurately as eye doctors, so that screening can happen in regul…

This study uses an artificial intelligence tool to analyze echocardiograms and identify undiagnosed heart failure in people with type 2 diabetes. Researchers will test whether providing these AI results to doctors helps them prescribe preventive medications. About 800 participant…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults who are at risk for dementia and diabetes. One group will do aerobic exercise classes, and the other will get dietary counseling to follow the MIND diet (rich in berries, vegetable…

This study tests a family-oriented program to help Black families in Southwest Georgia lower their risk for type 2 diabetes. Parents with prediabetes and their children aged 8-15 will take part in a 20-month healthy lifestyle program. The goal is to see if parents can achieve a 4…

This early-phase study tests whether tirzepatide, a weight-loss medication, can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The main goal is to see if the program is safe and feasible. About 30 men will ta…

This study tests whether group counseling and peer support can help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain feel less stigma about their health. About 195 adults will join counseling sessions and report how stigma affects their li…

This study tests a telemedicine-delivered cognitive behavioral therapy program designed to reduce anxiety and depression in young adults with type 1 diabetes. About 94 participants will receive the therapy along with continuous glucose monitor review. The goal is to see if this a…

This study looks at whether a special computer program can help doctors better manage blood sugar levels in hospitalized adults. The tool alerts care teams when a patient's blood sugar is too high or too low, so they can act quickly. Researchers will track how long patients stay …

This study looks at people with type 2 diabetes who have nerve damage in their legs. Researchers will use ultrasound to measure leg nerves and test how well participants walk and keep their balance. The goal is to see if nerve size and appearance are linked to movement problems, …

This study asks adults with type 1 diabetes who use a closed-loop insulin system how they feel about the special 'physical activity mode' designed to prevent low blood sugar during exercise. Researchers will use a questionnaire to gather feedback from up to 900 participants. The …

This study aims to understand how obesity and diabetes influence gene activity in tissues that process sugar and fat. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn how body weight and blood sugar levels change ge…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples like blood and wound fluid from 5,000 adults with diabetes and an open foot ulcer. The goal is to develop tools that help doct…

This study looks at how common memory problems are in people aged 65 and older with type 2 diabetes. It also tests whether a program that combines healthy habits, exercise, and mental activities can help prevent or slow down memory decline. The study involves 420 participants fro…

This study uses MRI scans to measure pancreas size in pregnant women and their unborn babies. Researchers want to see how the pancreas changes during pregnancy and how those changes are linked to diabetes. The goal is to better understand diabetes risk for both mother and child. …

People with serious mental illness often have undiagnosed physical problems like heart disease, diabetes, or cancer. This study adds routine health checkups to psychiatric clinics to see if they catch these hidden conditions better than usual care. About 2,800 adults with psychot…

This study aims to uncover the genetic and lifestyle factors that contribute to type 2 diabetes in African populations, particularly the Yoruba people in Nigeria. Researchers will compare 300 people with diabetes to 300 without, using blood samples and health questionnaires. The …

This study looks at how fat buildup in the pancreas (pancreatic steatosis) relates to diabetes and metabolic syndrome. Researchers will use a special ultrasound to measure the fat and compare it with blood sugar and other health markers in 100 adults. The goal is to better unders…

This study tests whether a training session for hospital doctors can help them feel more confident when prescribing medications for older adults with diabetes and high blood pressure. About 150 doctors will attend a one-time educational session and complete surveys before and aft…

This study is creating a biobank—a collection of DNA samples and health information—from 500 adults. Researchers will use this resource to study genetic links to heart disease, high blood pressure, diabetes, and obesity. The goal is to provide a valuable tool for future medical d…

This study will enroll 200 adolescents and adults with cystic fibrosis-related diabetes (CFRD) to find out how common complications like eye, kidney, and nerve problems are. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks a…

This study looks at whether pregnant women with high-risk conditions like diabetes or high blood pressure can use a home device to monitor their baby's health instead of going to the clinic. Fifty participants will try the device for 30 minutes, three times a week, starting at 32…

This study is creating a large collection of human biological samples and health information, called a biobank. Researchers will use these materials to study the causes of diseases like cancer, heart disease, and diabetes. Up to 10,000 participants will provide samples and data t…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to collect information on blood sugar control, complications, and quality of life over many years. The goal is to better understand the disease and improve care, not to test a…

This study aims to improve how we measure metabolism—the rate your body burns calories—by looking at body shape and composition. Researchers will compare healthy volunteers and people with conditions like diabetes, obesity, or cancer. Participants spend two days in the hospital f…

This study collects genetic and health information from 3,000 people to help doctors choose the right medications and avoid side effects. Participants include those taking multiple medications or specific drugs for blood pressure or depression. The goal is to learn how genes affe…

This study aims to make sure lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone disorders are accurate and give consistent results. It will involve up to 100 healthy volunteers and people with these conditions, aged 18 to 100. The …

This study explores whether using advanced insulin pumps right after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests among kids using standard therapy, automated insulin del…

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans, physical tests, and blood draws. The goal is to understand how the drug affects muscle health, especially in people at ri…

This study will follow 2,000 adults with metabolic syndrome or prediabetes for many years. Researchers will track health changes, risk factors, and complications to better understand how these conditions progress. The goal is to find key factors that affect long-term health outco…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and develop better cell-based tre…

This study looks at how being an unpaid caregiver for someone with a long-term illness affects your health and well-being over time. Researchers will follow about 2,800 adult caregivers for up to 5 years using surveys, phone interviews, and diaries. The goal is to understand the …

This study uses a special PET-MR scan to measure a protein called HDAC in the heart. Researchers will compare HDAC levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how heart disease develops, not to provide treatme…

This study looks at whether the anesthetic propofol can lower the chance of confusion (delirium) after surgery in diabetic patients aged 60 and older. About 450 people having non-cardiac surgery will be randomly assigned to receive either propofol or sevoflurane during their oper…

This study aims to improve health research participation among Black, Latino, and Native American communities in Colorado. Researchers will work with local organizations to address health issues like mental health, high blood pressure, and diabetes. About 1,500 adults aged 18-90 …

This study looks at whether obesity raises heart disease risk in African American men and women. Researchers will measure body fat, blood fats, and how well insulin works in 2000 healthy non-diabetic adults. The goal is to understand why heart disease risk factors may differ betw…