Young-onset Parkinson disease
MONDO:0017279A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
Also known as: YOPD, early-onset Parkinson disease, early-onset Parkinson's disease
23 clinical trials for this condition and its sub-types, 9 tagged with Young-onset Parkinson disease itself.
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Sub-types of Young-onset Parkinson disease
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Parkinson disease 10 0 trials
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Parkinson disease 12 0 trials
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Early-onset Parkinson disease 20 0 trials
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Juvenile-onset Parkinson disease 0 trials
3 sub-types
- Kufor-Rakeb syndrome 0 trials Sub-types →
- Parkinson disease 19B, early-onset 0 trials
- Juvenile onset Parkinson disease 19A 0 trials
Most studied deeper sub-types
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Brain gene therapy aims to boost dopamine in young Parkinson's patients
Disease control Not yet recruitingThis early-stage trial tests a gene therapy called AAV2-hAADC in 9 adults with young-onset Parkinson's disease. The therapy delivers a gene directly to two brain regions (putamen and caudate) to help convert levodopa into dopamine more efficiently. The main goal is to check safet…
Phase 1 • Sponsor: Krzysztof Bankiewicz • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Can a new pill slow Parkinson's symptoms?
Disease control Not yet recruitingThis clinical trial is testing an experimental medication called TJ0113 in people with early-onset Parkinson's disease. The study aims to see if TJ0113 can improve movement symptoms compared to a placebo. About 300 participants will take either TJ0113 or a placebo for 26 weeks, f…
Phase 3 • Sponsor: Hangzhou PhecdaMed Co., Ltd. • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC