Thalassemia
MONDO:0000984An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation.
Also known as: sickle-cell thalassemia with crisis, sickle-cell thalassemia without crisis
138 clinical trials for this condition and its sub-types, 49 tagged with Thalassemia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Thalassemia
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Beta thalassemia 73 trials · 99 incl. sub-types
3 sub-types
- Beta-thalassemia HBB/LCRB 2 trials · 57 incl. sub-types Sub-types →
- Dominant beta-thalassemia 0 trials
- Thalassemia, beta+, silent allele 0 trials
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Alpha thalassemia spectrum 11 trials · 12 incl. sub-types
2 sub-types
- Digenic alpha thalassemia spectrum 0 trials · 8 incl. sub-types Sub-types →
- Monogenic alpha thalassemia spectrum 0 trials Sub-types →
Most studied deeper sub-types
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Triple therapy aims to overcome antibody barrier in Half-Matched stem cell transplants
Disease control Not yet recruitingThis study tests whether a combination of dexamethasone, intravenous immunoglobulin (IVIG), and extra donor immune cells can safely lower harmful antibodies that attack donor stem cells in half-matched (haploidentical) transplants. The trial enrolls 60 adults aged 18–65 with bloo…
Phase 2 • Sponsor: Hematology department of the 920th hospital • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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New hope for thalassemia: drug trial targets anemia without transfusions
Disease control Not yet recruitingThis study tests a new drug called SNH-119014 in 30 adults with a type of thalassemia that does not require regular blood transfusions. The goal is to see if the drug is safe and helps improve anemia. Participants will be monitored for side effects and how their body responds to …
Phase 2 • Sponsor: ScinnoHub Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Talking therapy could help thalassemia patients take their meds
Symptom relief Not yet recruitingThis study tests whether motivational interviewing, a type of counseling, can help adults with beta-thalassemia major follow their iron chelation therapy more consistently. Forty-five participants in Oman will receive three one-on-one sessions with a nurse over six to eight weeks…
Sponsor: Oman Ministry of Health • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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What does thalassemia really cost children and families?
Knowledge-focused Not yet recruitingThis study measures the clinical, economic, and psychosocial burden of thalassemia in children and adolescents in Sohag, Egypt. Researchers will track hospital visits, blood transfusions, and complications, and estimate direct medical costs plus indirect costs like missed school …
Sponsor: Randa Elham Hamam • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Anemia may skew diabetes test results, new study warns
Knowledge-focused Not yet recruitingThis study looks at how different types of anemia—like iron deficiency or thalassemia—can change HbA1c levels, a common test for diabetes, in people who do not have diabetes. Researchers will compare HbA1c results between 100 non-diabetic adults with various anemias and a healthy…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Greek study to measure daily life impact of iron overload drug
Knowledge-focused Not yet recruitingThis study looks at how thalassemia patients in Greece feel day-to-day while taking a standard iron-removing medicine called deferasirox. Researchers will survey 150 adults to measure their physical and mental well-being. The goal is to understand real-world quality of life, not …
Sponsor: Elpen Pharmaceutical Co. Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC