Squamous cell carcinoma of penis
MONDO:0018352A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)
Also known as: epidermoid carcinoma of penis, epidermoid carcinoma of the penis, epidermoid cell carcinoma of penis, epidermoid cell carcinoma of the penis, penile epidermoid carcinoma, penile epidermoid cell carcinoma, penile squamous car.(epidermoid), penile squamous carcinoma (epidermoid)
2776 clinical trials for this condition and its sub-types, 21 tagged with Squamous cell carcinoma of penis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Squamous cell carcinoma of penis
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2 sub-types
- Basaloid carcinoma of the penis 0 trials
- Warty carcinoma of the penis 0 trials
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Penis carcinoma in situ 1 trial
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Papillary carcinoma of the penis 0 trials
2 sub-types
- Penis verrucous carcinoma 0 trials Sub-types →
- Warty carcinoma of the penis 0 trials
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Penis mixed squamous cell carcinoma 0 trials
Most studied deeper sub-types
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Can a Two-Drug punch erase penile cancer before surgery?
Cure Not yet recruitingThis trial tests whether combining two drugs—pucotenlimab, which helps the immune system attack cancer, and becotatug vedotin, which delivers a toxin directly to tumor cells—can eliminate advanced penile cancer before surgery. Men with high-risk, locally advanced penile squamous …
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Cure
Last updated Aug 19, 2026 00:00 UTC
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Can a targeted drug shrink advanced penile cancer when chemotherapy stops working?
Disease control Not yet recruitingThis Phase 2 trial tests amivantamab, a targeted drug given as a shot under the skin, in adults with advanced penile cancer that has spread or returned after at least one round of platinum-based chemotherapy. The study includes two groups based on HPV status and measures how many…
Phase 2 • Sponsor: Latin American Cooperative Oncology Group • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Antibody-Drug conjugate aims to hit Hard-to-Treat penile cancer
Disease control Not yet recruitingPenile squamous cell carcinoma is a rare and aggressive cancer with limited options once it progresses after platinum-based chemotherapy. This phase 2 trial tests sacituzumab tirumotecan, an antibody-drug conjugate that targets the TROP-2 protein on cancer cells, in about 37 part…
Phase 2 • Sponsor: Latin American Cooperative Oncology Group • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC