Smallpox
MONDO:0004651A condition that is caused by infection with Variola, and that is characterized by small, raised bumps.
Also known as: Variola virus caused disease or disorder, Variola virus disease or disorder, Variola virus infectious disease, ordinary smallpox, Variola, smallpox virus infection, variola virus VAR infection, variola virus infection
18 clinical trials for this condition and its sub-types, 15 tagged with Smallpox itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Smallpox
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Variola major infectious disease 0 trials
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Variola minor infection 0 trials
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New smallpox vaccine shows promise in early trial
Vaccine CompletedThis study tested an experimental smallpox vaccine called IMVAMUNE in 226 healthy adults who had never received a smallpox vaccine. Participants received either the IMVAMUNE vaccine or a placebo, and researchers monitored their immune responses and any side effects for up to 425 …
Phase 1/2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Vaccine
Last updated Jun 26, 2026 18:53 UTC
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Can common kidney drugs weaken the smallpox antiviral TPOXX?
Disease control CompletedResearchers are testing whether four common phosphate binders change how the body processes the smallpox antiviral TPOXX. The study enrolls 44 healthy adults aged 18 to 50 with normal phosphorus levels. Each participant receives TPOXX alone and with each binder in a five-period c…
Phase 4 • Sponsor: SIGA Technologies • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Smallpox drug put to the test in heavier adults
Disease control CompletedResearchers are studying the smallpox antiviral TPOXX in adults who weigh more than 120 kg. The trial measures how the drug moves through the body and checks for side effects over a week of dosing. The goal is to see whether this group processes the drug differently, which could …
Phase 4 • Sponsor: SIGA Technologies • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Smallpox drug put to the test in healthy volunteers
Prevention CompletedResearchers are testing an antiviral drug called tecovirimat to see if it is safe and well tolerated when taken by mouth for 14 days. The trial enrolls healthy adults aged 18 to 80 and compares tecovirimat with a placebo. The goal is to gather safety information that could suppor…
Phase 3 • Sponsor: SIGA Technologies • Aim: Prevention
Last updated Sep 13, 2026 00:00 UTC
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Smallpox drug put to the test: can TPOXX be taken safely for a month?
Prevention CompletedResearchers are studying whether an antiviral drug called tecovirimat (TPOXX) is safe and well tolerated when taken by mouth twice daily for 28 days. The trial enrolls healthy adults aged 18 to 80 and compares TPOXX with a placebo. The main goal is to measure drug levels in the b…
Phase 3 • Sponsor: SIGA Technologies • Aim: Prevention
Last updated Sep 13, 2026 00:00 UTC
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Antiviral tecovirimat put to the test for smallpox threat
Prevention CompletedResearchers tested two doses of tecovirimat, an antiviral drug, in healthy volunteers to see how safe and well-tolerated it is. Participants took a daily oral dose for 14 days, and researchers monitored side effects and measured drug levels in the blood. The goal was to find the …
Phase 2 • Sponsor: SIGA Technologies • Aim: Prevention
Last updated Sep 13, 2026 00:00 UTC