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Severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency

MONDO:0017994

2 clinical trials for this condition and its sub-types, 2 tagged with Severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency itself.

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Part of

↑ Hereditary disease (19202) ↑ Syndromic disease (7538)

Including sub-types (2) Tagged with Severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency (2)

Not yet finished but already full! 1 Completed 1

Can a daily tablet rewire hunger signals in rare genetic obesity?

Disease control Cancelled

Researchers are testing DCCR (diazoxide choline) extended-release tablets in people with rare genetic obesities caused by SH2B1, PCSK1, or SIM1 mutations. Participants take the tablets daily for up to a year, with the dose increased over the first four weeks. The study measures w…

Phase 2 • Sponsor: Soleno Therapeutics, Inc. • Aim: Disease control

Last updated Oct 15, 2026 00:00 UTC