Rickets
MONDO:0005520Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities.
Also known as: rachitis, rickets, rickets (disease), vitamin D hydroxylation-deficient rickets, active rickets, hypovitaminosis D, nutritional rickets, vitamin D deficiency disease
41 clinical trials for this condition and its sub-types, 10 tagged with Rickets itself.
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Sub-types of Rickets
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Hypophosphatemic rickets 3 trials · 19 incl. sub-types
1 sub-type
- Hereditary hypophosphatemic rickets 1 trial · 18 incl. sub-types Sub-types →
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Renal osteodystrophy 12 trials
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Hypocalcemic rickets 0 trials · 3 incl. sub-types
2 sub-types
- Vitamin D-dependent rickets, type 1 0 trials · 3 incl. sub-types Sub-types →
- Vitamin D-dependent rickets, type 2 0 trials Sub-types →
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Vitamin D-dependent rickets 0 trials · 3 incl. sub-types
3 sub-types
- Vitamin D-dependent rickets, type 1 0 trials · 3 incl. sub-types Sub-types →
- Vitamin D-dependent rickets, type 2 0 trials Sub-types →
- Vitamin D-dependent rickets, type 3 0 trials
Most studied deeper sub-types
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Can a vitamin d pill improve bone health in rare genetic disease?
Disease control CompletedThis study tested whether giving only calcitriol (a form of vitamin D) to 16 children and adults with X-linked hypophosphatemia (XLH) could raise blood phosphate levels and improve bone growth without causing kidney stones. Participants took increasing doses of calcitriol for one…
Early phase 1 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Experimental drug aims to fix Bone-Weakening phosphate problem in rare disease
Disease control CompletedThis study tested a drug called burosumab in 12 people with fibrous dysplasia who also had low blood phosphate, which can make bones weaker. Participants injected the drug at home once or twice a month for 48 weeks. The main goal was to see if the drug could raise phosphate level…
Phase 2 • Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New diaper-like device could spare preemies from painful urine tests
Knowledge-focused CompletedThis study tested a new device to collect urine from premature newborns in a gentler way. The goal was to see if it is easy for nurses to use and comfortable for babies. Twenty babies took part, and the device was compared to current methods. The study focused on how well the dev…
Sponsor: Capturin Distribution B.V. • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC