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RAD51C-related cancer predisposition

MONDO:0700273

Hereditary cancer predisposition due to variation(s) in the RAD51C gene. Pathogenic germline variation in RAD51C confers an autosomal dominant predisposition to tumor formation at multiple primary sites, including ovarian cancer, triple negative breast cancer and ER negative breast cancer.

38 clinical trials for this condition and its sub-types, 6 tagged with RAD51C-related cancer predisposition itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary neoplastic syndrome (731)

Including sub-types (38) Tagged with RAD51C-related cancer predisposition (6)

Trials to join now! 2 Not yet finished but already full! 2 Completed 1 Terminated 1

Cancer drug niraparib tested before prostate surgery – early trial stopped

Disease control Stopped early

This phase II trial tested the drug niraparib (Zejula) in 11 men with high-risk prostate cancer that had not spread. All men had specific DNA repair gene mutations. They took niraparib before having their prostate removed surgically. The goal was to see if the drug could eliminat…

Phase 2 • Sponsor: University of California, Davis • Aim: Disease control

Last updated Jun 27, 2026 12:33 UTC