Permanent neonatal diabetes mellitus

MONDO:0100164

Permanent neonatal diabetes mellitus (PNDM) is a monogenic form of neonatal diabetes (NDM) characterized by persistent hyperglycemia within the first 12 months of life in general, requiring continuous insulin treatment.

Also known as: PNDM, monogenic diabetes of infancy, developmental delay, epilepsy, and neonatal diabetes, diabetes mellitus, permanent neonatal, diabetes mellitus, permanent neonatal, with neurologic features, diabetes mellitus, permanent, of infancy

37 clinical trials for this condition and its sub-types, 2 tagged with Permanent neonatal diabetes mellitus itself.

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Where it sits in the disease tree

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↑ Disorder of glycolysis (27) ↑ Neonatal diabetes mellitus (6)

Sub-types of Permanent neonatal diabetes mellitus

DEND syndrome 0 trials
3 sub-types
- Developmental delay, epilepsy, and neonatal diabetes 1 0 trials
- Developmental delay, epilepsy, and neonatal diabetes 2 0 trials
- Intermediate DEND syndrome 0 trials
Diabetes mellitus, permanent neonatal 2 0 trials
Diabetes mellitus, permanent neonatal 3 0 trials
Diabetes mellitus, permanent neonatal 4 0 trials
Permanent neonatal diabetes mellitus 1 0 trials

Including sub-types (37) Tagged with Permanent neonatal diabetes mellitus (2)

Not yet finished but already full! 1 Completed 1

Pill may free babies with rare diabetes from daily insulin shots

Disease control Completed

This study tested whether babies with a rare, permanent form of diabetes caused by specific gene changes could switch from daily insulin injections to an oral pill called glibenclamide. Nineteen infants took part. The goal was to see if the pill could control their blood sugar an…

Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control

Last updated Jun 27, 2026 07:59 UTC

Permanent neonatal diabetes mellitus

Where it sits in the disease tree

Pill may free babies with rare diabetes from daily insulin shots