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PALB2-related cancer predisposition

MONDO:0700272

Hereditary cancer predisposition due to variation(s) in the PALB2 gene. Pathogenic germline variation in PALB2 confers an autosomal dominant predisposition to tumor formation at multiple primary sites, including breast cancer, ovarian cancer, and pancreatic cancer.

46 clinical trials for this condition and its sub-types, 14 tagged with PALB2-related cancer predisposition itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary neoplastic syndrome (731)

Sub-types of PALB2-related cancer predisposition

Pancreatic cancer, susceptibility to, 3 0 trials

Including sub-types (46) Tagged with PALB2-related cancer predisposition (14)

Trials to join now! 6 Not yet finished but already full! 7 Completed 1

Can a Hormone-Binding protein predict breast cancer risk? trial tests tamoxifen and fasting

Prevention Completed

Researchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…

Phase 2 • Sponsor: European Institute of Oncology • Aim: Prevention

Last updated Sep 13, 2026 00:00 UTC