Oral cavity squamous cell carcinoma
MONDO:0004958A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.
Also known as: mouth scc, mouth squamous cell carcinoma, oral cavity scc, oral cavity squamous cell cancer, oral cavity squamous cell carcinoma, scc of mouth, scc of oral cavity, scc of the mouth
3121 clinical trials for this condition and its sub-types, 141 tagged with Oral cavity squamous cell carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Oral cavity squamous cell carcinoma
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Tongue squamous cell carcinoma 9 trials · 13 incl. sub-types
1 sub-type
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2 sub-types
- Parotid gland squamous cell carcinoma 0 trials
- Salivary gland adenosquamous carcinoma 0 trials
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Verrucous carcinoma of oral cavity 3 trials
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Squamous cell carcinoma of lip 2 trials
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Experimental drug targets Hard-to-Treat cancers, but trial ends early
Disease control Stopped earlyThis study tested an experimental drug called vobramitamab duocarmazine in people with advanced prostate cancer and other solid tumors that stopped responding to standard treatments. The goal was to see if the drug could shrink tumors or slow cancer growth. The trial was terminat…
Phase 2 • Sponsor: MacroGenics • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Peptide vaccine shows promise in head and neck cancer trial
Disease control Stopped earlyThis study tested a peptide-based immunotherapy in 17 people with head and neck cancer who were scheduled for surgery. The goal was to see if the vaccine could boost the immune system's attack on cancer cells and to check for side effects. The trial was stopped early, but the res…
Phase 2 • Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Glow-in-the-Dark dye could help surgeons spot hidden oral cancer cells
Diagnosis Stopped earlyThis study tested a dye called tozuleristide that makes oral cancer cells glow under special light during surgery. The goal was to help surgeons see and remove all cancer while sparing healthy tissue. The trial included 8 adults with oral cavity cancer or high-grade dysplasia. Th…
Phase 1/2 • Sponsor: University of Washington • Aim: Diagnosis
Last updated Sep 18, 2026 00:00 UTC
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New imaging tool could help surgeons spot invisible oral cancers
Diagnosis Stopped earlyThis study tested whether a special imaging technique called narrow band imaging (NBI) can help surgeons find early cancer spots in the mouth that are not visible under normal light. The trial involved 23 people with oral cancer who were already scheduled for surgery. Doctors com…
Phase 2 • Sponsor: Centre Oscar Lambret • Aim: Diagnosis
Last updated Jun 27, 2026 11:01 UTC
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Virtual implants may save jawbone during cancer radiation
Knowledge-focused Stopped earlyThis study tested a new planning method to protect areas where dental implants could later be placed in patients receiving radiation for head and neck cancer. Researchers used virtual implant markers on CT scans to adjust radiation doses, aiming to keep implant sites safe without…
Sponsor: Institut de cancérologie Strasbourg Europe • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC