Mitochondrial respiratory chain complex deficiency
MONDO:0000066A mitochondrial energy metabolism disorder where respiratory complex (I–V) is dysfunctional, typically due to mutations in genes encoding that specific complex’s proteins or assembly factors.
Also known as: isolated oxidative phosphorylation complex disorder, mitochondrial complex deficiency
16 clinical trials for this condition and its sub-types, 4 tagged with Mitochondrial respiratory chain complex deficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Mitochondrial respiratory chain complex deficiency
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Mitochondrial complex I deficiency 2 trials
2 sub-types
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22 sub-types
- COX deficiency, benign infantile mitochondrial myopathy 0 trials
- Mitochondrial complex 4 deficiency, nuclear type 25 0 trials
- Mitochondrial complex IV deficiency, nuclear type 1 0 trials
- Mitochondrial complex IV deficiency, nuclear type 10 0 trials
- Mitochondrial complex IV deficiency, nuclear type 11 0 trials
- Mitochondrial complex IV deficiency, nuclear type 12 0 trials
- Mitochondrial complex IV deficiency, nuclear type 14 0 trials
- Mitochondrial complex IV deficiency, nuclear type 15 0 trials
- Mitochondrial complex IV deficiency, nuclear type 16 0 trials
- Mitochondrial complex IV deficiency, nuclear type 17 0 trials
- Mitochondrial complex IV deficiency, nuclear type 18 0 trials
- Mitochondrial complex IV deficiency, nuclear type 19 0 trials
- Mitochondrial complex IV deficiency, nuclear type 20 0 trials
- Mitochondrial complex IV deficiency, nuclear type 21 0 trials
- Mitochondrial complex IV deficiency, nuclear type 22 0 trials
- Mitochondrial complex IV deficiency, nuclear type 23 0 trials
- Mitochondrial complex IV deficiency, nuclear type 24 0 trials
- Mitochondrial complex IV deficiency, nuclear type 3 0 trials
- Mitochondrial complex IV deficiency, nuclear type 4 0 trials
- Mitochondrial complex IV deficiency, nuclear type 7 0 trials
- Mitochondrial complex IV deficiency, nuclear type 8 0 trials
- Pancreatic insufficiency-anemia-hyperostosis syndrome 0 trials
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SDHC-related Mitochondrial Disease 0 trials
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Mitochondrial complex III deficiency 0 trials
1 sub-type
Most studied deeper sub-types
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Could a common supplement ease gulf war illness symptoms?
Disease control Recruiting nowThis study tests whether a high-quality form of coenzyme Q10, a natural substance, can help reduce symptoms and improve daily life in veterans with Gulf War illness. Researchers will compare the supplement to a placebo in 192 veterans. The goal is to see if this approach offers a…
Phase 3 • Sponsor: University of California, San Diego • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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NIH launches study to uncover link between infections and mitochondrial disease
Knowledge-focused Recruiting nowThis study at the National Institutes of Health looks at how infections can worsen symptoms in people with mitochondrial disease, a group of disorders that affect energy production in cells. Researchers will evaluate participants' immune systems through blood tests, physical exam…
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists launch massive mitochondrial disease registry to unlock secrets of rare disorders
Knowledge-focused Recruiting nowThis study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC