Lung sarcomatoid carcinoma

MONDO:0006279

A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor.

Also known as: lung sarcomatoid carcinoma, sarcomatoid carcinoma of the lung

2812 clinical trials for this condition and its sub-types, 3 tagged with Lung sarcomatoid carcinoma itself.

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Where it sits in the disease tree

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Part of

↑ Lung large cell carcinoma (37) ↑ Sarcomatoid carcinoma (26)

Sub-types of Lung sarcomatoid carcinoma

Pulmonary blastoma 1 trial · 4 incl. sub-types
3 sub-types
- Pleuropulmonary blastoma 4 trials Sub-types →
- Classic pulmonary blastoma 0 trials
- Epithelial predominant pulmonary blastoma 0 trials
Lung giant cell carcinoma 1 trial
Lung pleomorphic carcinoma 1 trial

Most studied deeper sub-types

Pleuropulmonary blastoma type 1 (1) Pleuropulmonary blastoma type 2 (1) Pleuropulmonary blastoma type 3 (1) Fetal lung interstitial tumor (0)

Including sub-types (2812) Tagged with Lung sarcomatoid carcinoma (3)

Not yet finished but already full! 1 Completed 2

Immunotherapy duo takes on rare tumors

Disease control Ongoing

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 27, 2026 14:00 UTC

Lung sarcomatoid carcinoma

Where it sits in the disease tree

Most studied deeper sub-types

Immunotherapy duo takes on rare tumors