Langerhans cell histiocytosis
MONDO:0018310Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.
Also known as: LCH, Langerhans cell granulomatosis, Langerhans cell histiocytosis, Langerhans cell histiocytosis, NOS, Langerhans cell histiocytosis, Not otherwise specified, histiocytosis X, Langerhans-cell histiocytosis, Lch
1881 clinical trials for this condition and its sub-types, 40 tagged with Langerhans cell histiocytosis itself.
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Sub-types of Langerhans cell histiocytosis
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2 sub-types
- Hashimoto-Pritzker syndrome 0 trials
- Letterer-Siwe disease 0 trials
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1 sub-type
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Eosinophilic granuloma 0 trials
1 sub-type
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Hand-Schuller-Christian disease 0 trials
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Can a targeted pill tame a rare immune disease?
Disease control Not yet recruitingThis phase 2 trial is testing whether the experimental drug luvometinib, taken alone or with the chemotherapy drug cytarabine, can control Langerhans cell histiocytosis—a rare disease where immune cells build up and damage tissues. People aged 10 and older who need systemic treat…
Phase 2 • Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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500 patients to help unlock secrets of rare histiocytosis disorders
Knowledge-focused Not yet recruitingThis study will collect blood, saliva, urine, and stool samples from 500 adults with systemic histiocytosis—a group of rare inflammatory disorders. Researchers aim to identify biomarkers that could improve diagnosis, predict disease progression, and enable less invasive monitorin…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:07 UTC