Heritable pulmonary arterial hypertension
MONDO:0017148Heritable pulmonary arterial hypertension (HPAH) is a form of pulmonary arterial hypertension (PAH), occurring due to mutations in PAH predisposing genes or in a familial context. HPAH is characterized by elevated pulmonary arterial resistance leading to right heart failure. HPAH is progressive and potentially fatal.
Also known as: FPAH, HPAH, HpaH, familial pulmonary arterial hypertension, hereditary pulmonary arterial hypertension
34 clinical trials for this condition and its sub-types, 10 tagged with Heritable pulmonary arterial hypertension itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Heritable pulmonary arterial hypertension
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Pulmonary hypertension, primary, 1 0 trials
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Pulmonary hypertension, primary, 5 0 trials
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Pulmonary hypertension, primary, 6 0 trials
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Pulmonary hypertension, primary, 7 0 trials
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New PAH pill aims to delay worsening in large trial
Disease control CompletedThis study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…
Phase 3 • Sponsor: United Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Can a diabetes drug help PAH patients walk farther?
Symptom relief CompletedThis study tested whether metformin, a common diabetes drug, along with a text-message activity program, could help people with pulmonary artery hypertension (PAH) walk farther and feel better day-to-day. 73 adults with PAH took part. The goal was to see if these interventions im…
Phase 2 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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Diabetes drug semaglutide put to the test: can it reveal secrets of the adrenal gland?
Knowledge-focused CompletedThis completed study gave 22 healthy men a single dose of semaglutide (Rybelsus) or a placebo pill to see how it affects cortisol and other stress hormones. The goal was not to treat any disease, but to learn more about how GLP-1 drugs interact with the body's stress system. Part…
Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Small study probes Carnitine's role in rare lung disease
Knowledge-focused CompletedThis early-stage study looked at whether people with pulmonary arterial hypertension (PAH) have low carnitine levels and if taking carnitine supplements could help. Ten adults with PAH kept food diaries and had blood tests to measure carnitine. The goal was to gather information …
Phase 1 • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC