Hereditary spastic paraplegia 74

Autosomal recessive spastic paraplegia type 74 is a rare, genetic, spastic paraplegia-optic atrophy-neuropathy-related (SPOAN-like) disorder characterized by childhood onset of mild to moderate spastic paraparesis which manifests with gait impairment that very slowly progresses into late adulthood, hyperactive patellar reflex and bilateral extensor plantar response, in association with optic atrophy and typical symptoms of peripheral neuropathy, including reduced or absent ankle reflexes, lower limb atrophy and distal sensory impairment. Reduced visual acuity and pes cavus are frequently reported.

Also known as: IBA57 hereditary spastic paraplegia, SPG74, hereditary spastic paraplegia caused by mutation in IBA57, hereditary spastic paraplegia type 74, autosomal recessive spastic paraplegia type 74, spastic paraplegia 74, autosomal recessive

2 clinical trials for this condition and its sub-types, 0 tagged with Hereditary spastic paraplegia 74 itself.