Hereditary hemophagocytic lymphohistiocytosis
MONDO:0015541An instance of hemophagocytic lymphohistiocytosis that is caused by an inherited genomic modification in an individual.
Also known as: familial hemophagocytic lymphohistiocytosis, genetic hemophagocytic lymphohistiocytosis, genetic hemophagocytic syndrome, primary hemophagocytic lymphohistiocytosis
57 clinical trials for this condition and its sub-types, 8 tagged with Hereditary hemophagocytic lymphohistiocytosis itself.
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Sub-types of Hereditary hemophagocytic lymphohistiocytosis
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Chediak-Higashi syndrome 9 trials
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Griscelli syndrome type 2 1 trial
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Hermansky-Pudlak syndrome 2 0 trials
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Hermansky-Pudlak syndrome 9 0 trials
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New hope for chinese HLH patients: emapalumab shows promise
Disease control CompletedThis study tested the drug emapalumab (Gamifant) in 13 Chinese patients with primary hemophagocytic lymphohistiocytosis (HLH), a rare and severe immune disorder. The goal was to see if the drug is safe and helps control the disease before a stem cell transplant. Researchers measu…
Phase 4 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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New drug combo shows promise for kids with rare immune disease
Disease control CompletedThis study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…
Phase 1/2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New study aims to crack the code of autoimmune diseases
Knowledge-focused CompletedThis study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC