Epidermolysis bullosa simplex

MONDO:0017610

Epidermolysis bullosa simplex (EBS) is a group of hereditary epidermolysis bullosa (HEB) disorders characterized by skin fragility resulting in intraepidermal blisters and erosions that occur either spontaneously or after physical trauma.

Also known as: EBS, EEB, epidermolysis bullosa simplex, epidermolysis bullosa intraepidermic

7 clinical trials for this condition and its sub-types, 6 tagged with Epidermolysis bullosa simplex itself.

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Where it sits in the disease tree

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↑ Inherited epidermolysis bullosa (38)

Sub-types of Epidermolysis bullosa simplex

Epidermolysis bullosa simplex 1B, generalized intermediate 1 trial
Epidermolysis bullosa simplex 1C, localized 1 trial
Epidermolysis bullosa simplex 1A, generalized severe 0 trials
Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive 0 trials
Epidermolysis bullosa simplex 2A, generalized severe 0 trials
Epidermolysis bullosa simplex 2B, generalized intermediate 0 trials
Epidermolysis bullosa simplex 2C, localized 0 trials
Epidermolysis bullosa simplex 2E, with migratory circinate erythema 0 trials
Epidermolysis bullosa simplex 2F, with mottled pigmentation 0 trials
Epidermolysis bullosa simplex 2d, generalized, intermediate or severe, autosomal recessive 0 trials
Epidermolysis bullosa simplex 3, localized or generalized intermediate, with BP230 deficiency 0 trials
Epidermolysis bullosa simplex 4, localized or generalized intermediate, autosomal recessive 0 trials
Epidermolysis bullosa simplex 5A, Ogna type 0 trials
Epidermolysis bullosa simplex 5B, with muscular dystrophy 0 trials
Epidermolysis bullosa simplex 5C, with pyloric atresia 0 trials
Epidermolysis bullosa simplex 6, generalized, with scarring and hair loss 0 trials
Epidermolysis bullosa simplex 7, with nephropathy and deafness 0 trials
Epidermolysis bullosa simplex with anodontia/hypodontia 0 trials
Epidermolysis bullosa simplex with nail dystrophy 0 trials
Suprabasal epidermolysis bullosa simplex 0 trials
3 sub-types
- Epidermolysis bullosa simplex due to plakophilin deficiency 0 trials
- Epidermolysis bullosa simplex superficialis 0 trials
- Lethal acantholytic epidermolysis bullosa 0 trials

Including sub-types (7) Tagged with Epidermolysis bullosa simplex (6)

Trials to join now! 2 Not yet recruiting 2 Not yet finished but already full! 1 Completed 1

Could botox stop blisters on the soles of people with a rare skin condition?

Symptom relief Completed

Researchers are testing whether injections of botulinum toxin into the soles of the feet can reduce blistering in people with localized epidermolysis bullosa simplex, a rare skin condition that causes painful foot blisters. The trial enrolls 18 people with similar blisters on bot…

Phase 2/3 • Sponsor: University Hospital, Toulouse • Aim: Symptom relief

Last updated Sep 21, 2026 19:00 UTC

Epidermolysis bullosa simplex

Where it sits in the disease tree

Could botox stop blisters on the soles of people with a rare skin condition?