B cell deficiency

MONDO:0002211

A broad classification of disorders where circulating numbers of B lymphocytes are decreased or ineffective. Complement components and the production of antibodies may also be deficient.

Also known as: B-cell deficiency, deficiency of humoral immunity, immunoglobulin heavy chain deficiency, immunoglobulin heavy chain deletion

119 clinical trials for this condition and its sub-types, 5 tagged with B cell deficiency itself.

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Where it sits in the disease tree

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Part of

↑ Leukocyte disorder (3581) ↑ Immunodeficiency disease (779) ↑ Inborn error of immunity (345)

Sub-types of B cell deficiency

Agammaglobulinemia 16 trials · 52 incl. sub-types
10 sub-types
- Syndromic agammaglobulinemia 7 trials · 37 incl. sub-types Sub-types →
- Activated PI3K-delta syndrome 5 trials · 6 incl. sub-types Sub-types →
- Isolated agammaglobulinemia 0 trials · 4 incl. sub-types Sub-types →
- Good syndrome 0 trials
- Agammaglobulinemia 10, autosomal dominant 0 trials
- Agammaglobulinemia 8b, autosomal recessive 0 trials
- Agammaglobulinemia 9, autosomal recessive 0 trials
- Agammaglobulinemia, autosomal recessive, due to BOB1 deficiency 0 trials
- Congenital agammaglobulinemia 0 trials Sub-types →
- Immunodeficiency 61 0 trials
Hyperimmunoglobulin syndrome 0 trials · 34 incl. sub-types
2 sub-types
- Hyper-IgE syndrome 5 trials · 26 incl. sub-types Sub-types →
- Hyper-IgM syndrome 8 trials · 9 incl. sub-types Sub-types →
Selective immunoglobulin deficiency disease 1 trial · 4 incl. sub-types
2 sub-types
- Dysgammaglobulinemia 1 trial · 4 incl. sub-types Sub-types →
- Selective IgD deficiency disease 0 trials
PAX5-related B lymphopenia and autism spectrum disorder 0 trials
Immunoglobulin beta deficiency 0 trials

Most studied deeper sub-types

Common variable immunodeficiency (29) Netherton syndrome (16) Combined immunodeficiency due to DOCK8 deficiency (6) Immunodeficiency 14 (6) Bruton-type agammaglobulinemia (4) Hyper-IgE recurrent infection syndrome 1, autosomal dominant (3) Hyper-IgM syndrome type 1 (3) Selective IgA deficiency disease (2) Selective IgG immunodeficiency (2) Selective IgG subclass deficiency (2) Selective IgM deficiency (2) Autosomal agammaglobulinemia (1) Hyper-IgM syndrome type 2 (1) Hyper-IgM syndrome type 3 (1) Hyper-IgM syndrome type 5 (1) Immunodeficiency, common variable, 12 (1) Pancytopenia due to IKZF1 mutations (1) Agammaglobulinemia 2, autosomal recessive (0) Agammaglobulinemia 3, autosomal recessive (0) Agammaglobulinemia 4, autosomal recessive (0)

Including sub-types (119) Tagged with B cell deficiency (5)

Trials to join now! 2 Not yet recruiting 1 Completed 2

B cell deficiency

Where it sits in the disease tree

Most studied deeper sub-types

Scientists hunt for hidden immunity to animal viruses in cambodia

Gut virus linked to liver damage in immune-deficient patients?