Aggressive systemic mastocytosis

MONDO:0020333

Aggressive systemic mastocytosis (ASM) is a severe and rare form of systemic mastocytosis (SM) characterized by considerable infiltration of mast cells in different tissues.

Also known as: ASM, aggressive systemic mastocytosis (morphologic abnormality)

1857 clinical trials for this condition and its sub-types, 4 tagged with Aggressive systemic mastocytosis itself.

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Where it sits in the disease tree

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↑ Systemic mastocytosis (24)

Sub-types of Aggressive systemic mastocytosis

Lymphoadenopathic mastocytosis with eosinophilia 0 trials

Including sub-types (1857) Tagged with Aggressive systemic mastocytosis (4)

Trials to join now! 2 Not yet finished but already full! 1 Completed 1

New targeted pill shows promise for rare blood cancer

Disease control Completed

This Phase 2 study tested avapritinib, a daily tablet that targets a specific genetic mutation, in 107 people with advanced systemic mastocytosis (a rare blood cancer). The main goal was to see how many patients had their tumors shrink or symptoms improve. Results suggest the dru…

Phase 2 • Sponsor: Blueprint Medicines Corporation • Aim: Disease control

Last updated Jun 27, 2026 12:24 UTC

Aggressive systemic mastocytosis

Where it sits in the disease tree

New targeted pill shows promise for rare blood cancer